TY - JOUR

T1 - Experimental approaches to modeling delirium in zebrafish (Danio rerio)

AU - Maslov, Gleb O.

AU - Kolesnikova, Tatyana O.

AU - Zabegalov, Konstantin N.

AU - Kalueff, Allan V.

N1 - Публикация для корректировки.

PY - 2022

Y1 - 2022

N2 - Delirium is an acute psychiatric syndrome characterized by impaired attention, perception and orientation in space. Albeit known for millennia, the mechanisms and risk factors of delirium remain poorly understood. Experimental animal models, especially rodents, become widely used to understand these pathogenetic aspects. However, a new model organism — zebrafish (Danio rerio) also has promise in this field. Discussed here, recent behavioral tests and protocols for zebrafish enable assessing their behavioral and cognitive function, and its experimental modulation by deliriant drugs and other factors.

AB - Delirium is an acute psychiatric syndrome characterized by impaired attention, perception and orientation in space. Albeit known for millennia, the mechanisms and risk factors of delirium remain poorly understood. Experimental animal models, especially rodents, become widely used to understand these pathogenetic aspects. However, a new model organism — zebrafish (Danio rerio) also has promise in this field. Discussed here, recent behavioral tests and protocols for zebrafish enable assessing their behavioral and cognitive function, and its experimental modulation by deliriant drugs and other factors.

KW - delirium

KW - experimental models

KW - zebrafish

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85166753326&origin=inward&txGid=a73571b15eee0a1ae4cfd13c5fbabac4

UR - https://www.mendeley.com/catalogue/56fa66f8-f926-3cc1-b966-27a876f2cb6b/

U2 - 10.17816/RCF202177-183

DO - 10.17816/RCF202177-183

M3 - Article

VL - 20

SP - 177

EP - 183

JO - Reviews on Clinical Pharmacology and Drug Therapy

JF - Reviews on Clinical Pharmacology and Drug Therapy

SN - 2542-1875

IS - 2

ER -