Standard

Evaluating the efficiency of the tumor-initiating stem cells eradication strategy on the example of ascite form of mouse gepatocarcinoma G-29. / Potter, E. A.; Ritter, G. S.; Dolgova, E. V. и др.

в: Voprosy Onkologii, Том 64, № 6, 01.01.2018, стр. 818-829.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Potter, EA, Ritter, GS, Dolgova, EV, Proskurina, AS, Kisaretova, PE, Efremov, YR, Nikolin, VP, Popova, NA, Taranov, OS, Ostanin, AA, Chernych, ER, Sidorov, SV, Kolchanov, NA & Bogachev, SS 2018, 'Evaluating the efficiency of the tumor-initiating stem cells eradication strategy on the example of ascite form of mouse gepatocarcinoma G-29', Voprosy Onkologii, Том. 64, № 6, стр. 818-829.

APA

Potter, E. A., Ritter, G. S., Dolgova, E. V., Proskurina, A. S., Kisaretova, P. E., Efremov, Y. R., Nikolin, V. P., Popova, N. A., Taranov, O. S., Ostanin, A. A., Chernych, E. R., Sidorov, S. V., Kolchanov, N. A., & Bogachev, S. S. (2018). Evaluating the efficiency of the tumor-initiating stem cells eradication strategy on the example of ascite form of mouse gepatocarcinoma G-29. Voprosy Onkologii, 64(6), 818-829.

Vancouver

Potter EA, Ritter GS, Dolgova EV, Proskurina AS, Kisaretova PE, Efremov YR и др. Evaluating the efficiency of the tumor-initiating stem cells eradication strategy on the example of ascite form of mouse gepatocarcinoma G-29. Voprosy Onkologii. 2018 янв. 1;64(6):818-829.

Author

Potter, E. A. ; Ritter, G. S. ; Dolgova, E. V. и др. / Evaluating the efficiency of the tumor-initiating stem cells eradication strategy on the example of ascite form of mouse gepatocarcinoma G-29. в: Voprosy Onkologii. 2018 ; Том 64, № 6. стр. 818-829.

BibTeX

@article{ea4b56f4b99d47b3bc28cd15e4af007f,
title = "Evaluating the efficiency of the tumor-initiating stem cells eradication strategy on the example of ascite form of mouse gepatocarcinoma G-29",
abstract = "Previously, we identified a treatment regimen ({"}3+1{"}) to synchronize and eradicate solid and ascites forms of murine Krebs-2 tumor. Using a similar strategy, we attempted to narrow down the treatment conditions for mouse hepatocarcinoma G-29 that can be passaged in mice as either ascites or solid grafts. We successfully developed the protocol that allowed elimination of the primary ascites. Our results indicate that the {"}3+1{"} treatment protocol wherein the final doses of cyclophosphamide and double-stranded DNA preparation are given on days 6 or 11 had the greatest therapeutic effect. Mean survival time was 36 days in treated mice vs 27 days in untreated controls. We further demonstrate that tightly scheduled cyclophosphamide treatment was in itself highly inhibitory to the growing G-29 ascites. It has been shown that in the case of ascitic form of G-29 tumor after synergistic action of cytostatic and double-stranded DNA preparation, secondary ascites arises following the appearance of peritoneal carcinomatous solid formation and, apparently, is its derivative.",
keywords = "Cyclophosphamide, Double-stranded DNA, Hepatocarcinoma G-29, Secondary ascites",
author = "Potter, {E. A.} and Ritter, {G. S.} and Dolgova, {E. V.} and Proskurina, {A. S.} and Kisaretova, {P. E.} and Efremov, {Y. R.} and Nikolin, {V. P.} and Popova, {N. A.} and Taranov, {O. S.} and Ostanin, {A. A.} and Chernych, {E. R.} and Sidorov, {S. V.} and Kolchanov, {N. A.} and Bogachev, {S. S.}",
year = "2018",
month = jan,
day = "1",
language = "English",
volume = "64",
pages = "818--829",
journal = "Voprosy Onkologii",
issn = "0507-3758",
publisher = "Izdatelstvo Meditsina",
number = "6",

}

RIS

TY - JOUR

T1 - Evaluating the efficiency of the tumor-initiating stem cells eradication strategy on the example of ascite form of mouse gepatocarcinoma G-29

AU - Potter, E. A.

AU - Ritter, G. S.

AU - Dolgova, E. V.

AU - Proskurina, A. S.

AU - Kisaretova, P. E.

AU - Efremov, Y. R.

AU - Nikolin, V. P.

AU - Popova, N. A.

AU - Taranov, O. S.

AU - Ostanin, A. A.

AU - Chernych, E. R.

AU - Sidorov, S. V.

AU - Kolchanov, N. A.

AU - Bogachev, S. S.

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Previously, we identified a treatment regimen ("3+1") to synchronize and eradicate solid and ascites forms of murine Krebs-2 tumor. Using a similar strategy, we attempted to narrow down the treatment conditions for mouse hepatocarcinoma G-29 that can be passaged in mice as either ascites or solid grafts. We successfully developed the protocol that allowed elimination of the primary ascites. Our results indicate that the "3+1" treatment protocol wherein the final doses of cyclophosphamide and double-stranded DNA preparation are given on days 6 or 11 had the greatest therapeutic effect. Mean survival time was 36 days in treated mice vs 27 days in untreated controls. We further demonstrate that tightly scheduled cyclophosphamide treatment was in itself highly inhibitory to the growing G-29 ascites. It has been shown that in the case of ascitic form of G-29 tumor after synergistic action of cytostatic and double-stranded DNA preparation, secondary ascites arises following the appearance of peritoneal carcinomatous solid formation and, apparently, is its derivative.

AB - Previously, we identified a treatment regimen ("3+1") to synchronize and eradicate solid and ascites forms of murine Krebs-2 tumor. Using a similar strategy, we attempted to narrow down the treatment conditions for mouse hepatocarcinoma G-29 that can be passaged in mice as either ascites or solid grafts. We successfully developed the protocol that allowed elimination of the primary ascites. Our results indicate that the "3+1" treatment protocol wherein the final doses of cyclophosphamide and double-stranded DNA preparation are given on days 6 or 11 had the greatest therapeutic effect. Mean survival time was 36 days in treated mice vs 27 days in untreated controls. We further demonstrate that tightly scheduled cyclophosphamide treatment was in itself highly inhibitory to the growing G-29 ascites. It has been shown that in the case of ascitic form of G-29 tumor after synergistic action of cytostatic and double-stranded DNA preparation, secondary ascites arises following the appearance of peritoneal carcinomatous solid formation and, apparently, is its derivative.

KW - Cyclophosphamide

KW - Double-stranded DNA

KW - Hepatocarcinoma G-29

KW - Secondary ascites

UR - http://www.scopus.com/inward/record.url?scp=85063515995&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:85063515995

VL - 64

SP - 818

EP - 829

JO - Voprosy Onkologii

JF - Voprosy Onkologii

SN - 0507-3758

IS - 6

ER -

ID: 19038682