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Epigenetic Mechanisms of Blood-Pressure Regulation. / Markel, A. L.; Redina, O. E.

в: Molekuliarnaia biologiia, Том 52, № 2, 27.04.2018, стр. 172-189.

Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование

Harvard

Markel, AL & Redina, OE 2018, 'Epigenetic Mechanisms of Blood-Pressure Regulation', Molekuliarnaia biologiia, Том. 52, № 2, стр. 172-189. https://doi.org/10.7868/S0026898418020027

APA

Markel, A. L., & Redina, O. E. (2018). Epigenetic Mechanisms of Blood-Pressure Regulation. Molekuliarnaia biologiia, 52(2), 172-189. https://doi.org/10.7868/S0026898418020027

Vancouver

Markel AL, Redina OE. Epigenetic Mechanisms of Blood-Pressure Regulation. Molekuliarnaia biologiia. 2018 апр. 27;52(2):172-189. doi: 10.7868/S0026898418020027

Author

Markel, A. L. ; Redina, O. E. / Epigenetic Mechanisms of Blood-Pressure Regulation. в: Molekuliarnaia biologiia. 2018 ; Том 52, № 2. стр. 172-189.

BibTeX

@article{8e2a606343b244ec864e25a5b7d761bb,
title = "Epigenetic Mechanisms of Blood-Pressure Regulation",
abstract = "The role of epigenetic mechanisms involved in blood-pressure regulation has been reviewed. It is known that some periods in early pre- and postnatal ontogenesis are very sensitive to some environmental and endogenous influences. These periods are characterized as highly vulnerable to the formation of a complex of epigenetic changes that may determine the trajectory of the further formation of physiological systems involved in the blood-pressure regulation. Early life influences on these systems may predispose an individual to the development of hypertensive disease in further life. In some cases, the transmission of epigenetic changes to the next generations may resolve the contradiction between the high heritability of arterial hypertensive disease and the low total contribution of polymorphic DNA variants in the population variability of blood pressure values.",
keywords = "blood pressure, epigenetic mechanisms, hypertension, Animals, Blood Pressure, Epigenesis, Genetic, Genetic Predisposition to Disease, Humans, Hypertension/genetics",
author = "Markel, {A. L.} and Redina, {O. E.}",
year = "2018",
month = apr,
day = "27",
doi = "10.7868/S0026898418020027",
language = "English",
volume = "52",
pages = "172--189",
journal = "Molekulyarnaya Biologiya",
issn = "0026-8984",
publisher = "Russian Academy of Sciences",
number = "2",

}

RIS

TY - JOUR

T1 - Epigenetic Mechanisms of Blood-Pressure Regulation

AU - Markel, A. L.

AU - Redina, O. E.

PY - 2018/4/27

Y1 - 2018/4/27

N2 - The role of epigenetic mechanisms involved in blood-pressure regulation has been reviewed. It is known that some periods in early pre- and postnatal ontogenesis are very sensitive to some environmental and endogenous influences. These periods are characterized as highly vulnerable to the formation of a complex of epigenetic changes that may determine the trajectory of the further formation of physiological systems involved in the blood-pressure regulation. Early life influences on these systems may predispose an individual to the development of hypertensive disease in further life. In some cases, the transmission of epigenetic changes to the next generations may resolve the contradiction between the high heritability of arterial hypertensive disease and the low total contribution of polymorphic DNA variants in the population variability of blood pressure values.

AB - The role of epigenetic mechanisms involved in blood-pressure regulation has been reviewed. It is known that some periods in early pre- and postnatal ontogenesis are very sensitive to some environmental and endogenous influences. These periods are characterized as highly vulnerable to the formation of a complex of epigenetic changes that may determine the trajectory of the further formation of physiological systems involved in the blood-pressure regulation. Early life influences on these systems may predispose an individual to the development of hypertensive disease in further life. In some cases, the transmission of epigenetic changes to the next generations may resolve the contradiction between the high heritability of arterial hypertensive disease and the low total contribution of polymorphic DNA variants in the population variability of blood pressure values.

KW - blood pressure

KW - epigenetic mechanisms

KW - hypertension

KW - Animals

KW - Blood Pressure

KW - Epigenesis, Genetic

KW - Genetic Predisposition to Disease

KW - Humans

KW - Hypertension/genetics

UR - http://www.scopus.com/inward/record.url?scp=85055079228&partnerID=8YFLogxK

UR - https://www.elibrary.ru/item.asp?id=32619491

U2 - 10.7868/S0026898418020027

DO - 10.7868/S0026898418020027

M3 - Review article

C2 - 29695687

AN - SCOPUS:85055079228

VL - 52

SP - 172

EP - 189

JO - Molekulyarnaya Biologiya

JF - Molekulyarnaya Biologiya

SN - 0026-8984

IS - 2

ER -

ID: 17180676