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Engineering chimeric antigen receptors. / Kulemzin, S. V.; Kuznetsova, V. V.; Mamonkin, M. и др.

в: Acta Naturae, Том 9, № 1, 01.01.2017, стр. 6-14.

Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование

Harvard

Kulemzin, SV, Kuznetsova, VV, Mamonkin, M, Taranin, AV & Gorchakov, AA 2017, 'Engineering chimeric antigen receptors', Acta Naturae, Том. 9, № 1, стр. 6-14. https://doi.org/10.32607/20758251-2017-9-1-6-14

APA

Kulemzin, S. V., Kuznetsova, V. V., Mamonkin, M., Taranin, A. V., & Gorchakov, A. A. (2017). Engineering chimeric antigen receptors. Acta Naturae, 9(1), 6-14. https://doi.org/10.32607/20758251-2017-9-1-6-14

Vancouver

Kulemzin SV, Kuznetsova VV, Mamonkin M, Taranin AV, Gorchakov AA. Engineering chimeric antigen receptors. Acta Naturae. 2017 янв. 1;9(1):6-14. doi: 10.32607/20758251-2017-9-1-6-14

Author

Kulemzin, S. V. ; Kuznetsova, V. V. ; Mamonkin, M. и др. / Engineering chimeric antigen receptors. в: Acta Naturae. 2017 ; Том 9, № 1. стр. 6-14.

BibTeX

@article{225b1fa9dfd546e4b016ba72173268e0,
title = "Engineering chimeric antigen receptors",
abstract = "Chimeric antigen receptors (CARs) are recombinant protein molecules that redirect cytotoxic lymphocytes toward malignant and other target cells. The high feasibility of manufacturing CAR-modified lymphocytes for the therapy of cancer has spurred the development and optimization of new CAR T cells directed against a broad range of target antigens. In this review, we describe the main structural and functional elements constituting a CAR, discuss the roles of these elements in modulating the anti-tumor activity of CAR T cells, and highlight alternative approaches to CAR engineering.",
keywords = "Adoptive immunotherapy, Cancer, Chimeric antigen receptor, T cells",
author = "Kulemzin, {S. V.} and Kuznetsova, {V. V.} and M. Mamonkin and Taranin, {A. V.} and Gorchakov, {A. A.}",
year = "2017",
month = jan,
day = "1",
doi = "10.32607/20758251-2017-9-1-6-14",
language = "English",
volume = "9",
pages = "6--14",
journal = "Acta Naturae",
issn = "2075-8251",
publisher = "Park Media Ltd.",
number = "1",

}

RIS

TY - JOUR

T1 - Engineering chimeric antigen receptors

AU - Kulemzin, S. V.

AU - Kuznetsova, V. V.

AU - Mamonkin, M.

AU - Taranin, A. V.

AU - Gorchakov, A. A.

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Chimeric antigen receptors (CARs) are recombinant protein molecules that redirect cytotoxic lymphocytes toward malignant and other target cells. The high feasibility of manufacturing CAR-modified lymphocytes for the therapy of cancer has spurred the development and optimization of new CAR T cells directed against a broad range of target antigens. In this review, we describe the main structural and functional elements constituting a CAR, discuss the roles of these elements in modulating the anti-tumor activity of CAR T cells, and highlight alternative approaches to CAR engineering.

AB - Chimeric antigen receptors (CARs) are recombinant protein molecules that redirect cytotoxic lymphocytes toward malignant and other target cells. The high feasibility of manufacturing CAR-modified lymphocytes for the therapy of cancer has spurred the development and optimization of new CAR T cells directed against a broad range of target antigens. In this review, we describe the main structural and functional elements constituting a CAR, discuss the roles of these elements in modulating the anti-tumor activity of CAR T cells, and highlight alternative approaches to CAR engineering.

KW - Adoptive immunotherapy

KW - Cancer

KW - Chimeric antigen receptor

KW - T cells

UR - http://www.scopus.com/inward/record.url?scp=85017535471&partnerID=8YFLogxK

U2 - 10.32607/20758251-2017-9-1-6-14

DO - 10.32607/20758251-2017-9-1-6-14

M3 - Review article

AN - SCOPUS:85017535471

VL - 9

SP - 6

EP - 14

JO - Acta Naturae

JF - Acta Naturae

SN - 2075-8251

IS - 1

ER -

ID: 10522439