TY - JOUR

T1 - Effects of different types of induced neonatal inflammation on development and behavior of C57BL/6 and BTBR mice

AU - Ryabushkina, Yuliya A.

AU - Ayriyants, Kseniya A.

AU - Sapronova, Anna A.

AU - Mutovina, Anastasia S.

AU - Kolesnikova, Maria M.

AU - Mezhlumyan, Eva V.

AU - Bondar, Natalya P.

AU - Reshetnikov, Vasiliy V.

N1 - This study was supported by government-funded projects (Russia) # FWNR-2022–0016.

PY - 2024/6/1

Y1 - 2024/6/1

N2 - Neuroinflammation in the early postnatal period can disturb trajectories of the completion of normal brain development and can lead to mental illnesses, such as depression, anxiety disorders, and personality disorders later in life. In our study, we focused on evaluating short- and long-term effects of neonatal inflammation induced by lipopolysaccharide, poly(I:C), or their combination in female and male C57BL/6 and BTBR mice. We chose the BTBR strain as potentially more susceptible to neonatal inflammation because these mice have behavioral, neuroanatomical, and physiological features of autism spectrum disorders, an abnormal immune response, and several structural aberrations in the brain. Our results indicated that BTBR mice are more sensitive to the influence of the neonatal immune activation (NIA) on the formation of neonatal reflexes than C57BL/6 mice are. In these experiments, the injection of lipopolysaccharide had an effect on the formation of the cliff aversion reflex in female BTBR mice. Nonetheless, NIA had no delayed effects on either social behavior or anxiety-like behavior in juvenile and adolescent BTBR and C57BL/6 mice. Altogether, our data show that NIA has mimetic-, age-, and strain-dependent effects on the development of neonatal reflexes and on exploratory activity in BTBR and C57BL/6 mice.

AB - Neuroinflammation in the early postnatal period can disturb trajectories of the completion of normal brain development and can lead to mental illnesses, such as depression, anxiety disorders, and personality disorders later in life. In our study, we focused on evaluating short- and long-term effects of neonatal inflammation induced by lipopolysaccharide, poly(I:C), or their combination in female and male C57BL/6 and BTBR mice. We chose the BTBR strain as potentially more susceptible to neonatal inflammation because these mice have behavioral, neuroanatomical, and physiological features of autism spectrum disorders, an abnormal immune response, and several structural aberrations in the brain. Our results indicated that BTBR mice are more sensitive to the influence of the neonatal immune activation (NIA) on the formation of neonatal reflexes than C57BL/6 mice are. In these experiments, the injection of lipopolysaccharide had an effect on the formation of the cliff aversion reflex in female BTBR mice. Nonetheless, NIA had no delayed effects on either social behavior or anxiety-like behavior in juvenile and adolescent BTBR and C57BL/6 mice. Altogether, our data show that NIA has mimetic-, age-, and strain-dependent effects on the development of neonatal reflexes and on exploratory activity in BTBR and C57BL/6 mice.

KW - BTBR mice

KW - Behavior

KW - LPS

KW - Neonatal inflammation

KW - Poly(I:C)

KW - Animals

KW - Mice, Inbred C57BL

KW - Female

KW - Lipopolysaccharides/pharmacology

KW - Male

KW - Animals, Newborn

KW - Mice

KW - Inflammation/chemically induced

KW - Poly I-C/pharmacology

KW - Anxiety/chemically induced

KW - Social Behavior

KW - Disease Models, Animal

KW - Exploratory Behavior/drug effects

KW - Behavior, Animal/drug effects

KW - Reflex/physiology

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85190409418&origin=inward&txGid=75413f341f4180aacbbb79cf82ee74e4

UR - https://www.elibrary.ru/item.asp?id=67420474

UR - https://www.mendeley.com/catalogue/a9dc2f33-2936-3f5b-85e3-1dc4b2e00f82/

U2 - 10.1016/j.physbeh.2024.114550

DO - 10.1016/j.physbeh.2024.114550

M3 - Article

C2 - 38614416

VL - 280

JO - Physiology and Behavior

JF - Physiology and Behavior

SN - 0031-9384

M1 - 114550

ER -