TY - JOUR

T1 - Effects of Assisted Reproductive Technologies on Behavior and Brain Development in a Mouse Model of Parkinson’s Disease

AU - Rozhkova, I. N.

AU - Kozeneva, V. S.

AU - Brusentsev, E. Yu.

AU - Rakhmanova, T. A.

AU - Shavshaeva, N. A.

AU - Afanasova, S. G.

AU - Igonina, T. N.

AU - Okotrub, S. V.

AU - Naprimerov, V. A.

AU - Amstislavsky, S. Ya.

N1 - This work was supported by the Russian Science Foundation (project no. 23-25-00123). Animals were maintained at the expense of the budget project of the ICG SB RAS (FWNR-2022-0023). No additional grants to conduct or supervise this particular research were obtained. Effects of Assisted Reproductive Technologies on Behavior and Brain Development in a Mouse Model of Parkinson's Disease / I. N. Rozhkova, V. S. Kozeneva, E. Yu. Brusentsev [et al.] // Journal of Evolutionary Biochemistry and Physiology. – 2025. – Vol. 61, No. 1. – P. 273-284. – DOI 10.1134/S0022093025010223.

PY - 2025/3/3

Y1 - 2025/3/3

N2 - Here, we investigated the long-term effects of assisted reproductive technologies (ARTs), such as in vitro embryo culture and embryo transfer, on behavior and brain development in B6.Cg-Tg mice, a model of Parkinson’s disease (PD), and wild-type C57BL/6 mice. Male offspring obtained via ARTs were compared to those conceived naturally. At the age of 6 months, mice were assessed for anxiety in the elevated plus maze and additionally had their body and brain mass measured. It was found that naturally conceived B6.Cg-Tg mice exhibited lower anxiety levels and larger brain mass compared to wild-type mice. The use of ARTs led to a decreased brain mass in B6.Cg-Tg offspring and significantly decreased their anxiety levels compared to controls. In wild-type C57BL/6 mice, ARTs caused no significant changes in brain mass or anxiety levels. The results demonstrate the impact of ARTs on behavior and brain development in offspring, particularly in those genetically predisposed to neurodegenerative diseases. These results accentuate the necessity of further studies of the long-term effects of ARTs, especially in the context of their influence on neurodevelopment and behavior, which has important medical implications.

AB - Here, we investigated the long-term effects of assisted reproductive technologies (ARTs), such as in vitro embryo culture and embryo transfer, on behavior and brain development in B6.Cg-Tg mice, a model of Parkinson’s disease (PD), and wild-type C57BL/6 mice. Male offspring obtained via ARTs were compared to those conceived naturally. At the age of 6 months, mice were assessed for anxiety in the elevated plus maze and additionally had their body and brain mass measured. It was found that naturally conceived B6.Cg-Tg mice exhibited lower anxiety levels and larger brain mass compared to wild-type mice. The use of ARTs led to a decreased brain mass in B6.Cg-Tg offspring and significantly decreased their anxiety levels compared to controls. In wild-type C57BL/6 mice, ARTs caused no significant changes in brain mass or anxiety levels. The results demonstrate the impact of ARTs on behavior and brain development in offspring, particularly in those genetically predisposed to neurodegenerative diseases. These results accentuate the necessity of further studies of the long-term effects of ARTs, especially in the context of their influence on neurodevelopment and behavior, which has important medical implications.

UR - https://www.mendeley.com/catalogue/6617d2df-96ca-3a21-8980-5402fb5427a4/

UR - https://elibrary.ru/item.asp?id=80408847

U2 - 10.1134/s0022093025010223

DO - 10.1134/s0022093025010223

M3 - Article

VL - 61

SP - 273

EP - 284

JO - Journal of Evolutionary Biochemistry and Physiology

JF - Journal of Evolutionary Biochemistry and Physiology

SN - 0022-0930

IS - 1

ER -