TY - JOUR

T1 - DNA Damage Response and Repair in Boron Neutron Capture Therapy

AU - Mechetin, Grigory V

AU - Zharkov, Dmitry O

N1 - Funding: This research was funded by the Russian Science Foundation (grant 19-74-20069 to D.O.Z.).

PY - 2023/1/2

Y1 - 2023/1/2

N2 - Boron neutron capture therapy (BNCT) is an approach to the radiotherapy of solid tumors that was first outlined in the 1930s but has attracted considerable attention recently with the advent of a new generation of neutron sources. In BNCT, tumor cells accumulate 10B atoms that react with epithermal neutrons, producing energetic α particles and 7Li atoms that damage the cell's genome. The damage inflicted by BNCT appears not to be easily repairable and is thus lethal for the cell; however, the molecular events underlying the action of BNCT remain largely unaddressed. In this review, the chemistry of DNA damage during BNCT is outlined, the major mechanisms of DNA break sensing and repair are summarized, and the specifics of the repair of BNCT-induced DNA lesions are discussed.

AB - Boron neutron capture therapy (BNCT) is an approach to the radiotherapy of solid tumors that was first outlined in the 1930s but has attracted considerable attention recently with the advent of a new generation of neutron sources. In BNCT, tumor cells accumulate 10B atoms that react with epithermal neutrons, producing energetic α particles and 7Li atoms that damage the cell's genome. The damage inflicted by BNCT appears not to be easily repairable and is thus lethal for the cell; however, the molecular events underlying the action of BNCT remain largely unaddressed. In this review, the chemistry of DNA damage during BNCT is outlined, the major mechanisms of DNA break sensing and repair are summarized, and the specifics of the repair of BNCT-induced DNA lesions are discussed.

KW - Humans

KW - Boron Neutron Capture Therapy

KW - DNA Damage

KW - Brain Neoplasms/radiotherapy

KW - Biological Phenomena

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85146798977&origin=inward&txGid=dd7344124138269294c44c0ce6e50ec4

UR - https://www.mendeley.com/catalogue/048c3871-9d3b-34bb-bc9b-75876115983b/

U2 - 10.3390/genes14010127

DO - 10.3390/genes14010127

M3 - Review article

C2 - 36672868

VL - 14

JO - Genes

JF - Genes

SN - 2073-4425

IS - 1

M1 - 127

ER -