Dexamethasone Reduces Cytokine mRNA Levels and Microglial Activity in the Brainstem of Newborn Rats

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Dexamethasone Reduces Cytokine mRNA Levels and Microglial Activity in the Brainstem of Newborn Rats. / Kalinina, T. s.; Bulygina, V. v.; Lanshakov, D. a. и др.

в: Neurochemical Journal, Том 18, № 4, 18.03.2025, стр. 643-648.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Author

Kalinina, T. s. ; Bulygina, V. v. ; Lanshakov, D. a. и др. / Dexamethasone Reduces Cytokine mRNA Levels and Microglial Activity in the Brainstem of Newborn Rats. в: Neurochemical Journal. 2025 ; Том 18, № 4. стр. 643-648.

BibTeX

@article{24f18402743b414394c9373aa966239e,

title = "Dexamethasone Reduces Cytokine mRNA Levels and Microglial Activity in the Brainstem of Newborn Rats",

abstract = "During the perinatal period of ontogeny, microglia performs functions of a critical key-regulator of the angio-, neuro-, and synaptogenesis processes. Under normal development, without inflammation induction, administration of the glucocorticoid hormone dexamethasone (0.2 mg/kg) caused a rapid decrease in the mRNA levels of both pro- and anti-inflammatory cytokines in the brainstem of neonatal rat pups. A decrease in the expression of the Il1b and Tnfa genes was observed within 1 h, and Il10 and Tgfb1, 4 h after the administration of the hormone to 3-day-old rat pups. Suppression of cytokine mRNA levels was accompanied by a decrease in the number of cells expressing the microglia marker protein IBA1 in the locus coeruleus region of the brainstem in 6 h after glucocorticoid administration. The identified features of the dexamethasone action can weaken the participation of microglia in the processes of neuroplasticity in the developing brain, which may be one of the reasons for long-term changes in brain functioning.",

author = "Kalinina, {T. s.} and Bulygina, {V. v.} and Lanshakov, {D. a.} and Sukhareva, {E. v.} and Dygalo, {N. n.}",

note = "Dexamethasone Reduces Cytokine mRNA Levels and Microglial Activity in the Brainstem of Newborn Rats / T. S. Kalinina, V. V. Bulygina, D. A. Lanshakov [et al.] // Neurochemical Journal. – 2024. – Vol. 18, No. 4. – P. 643-648. – DOI 10.1134/S1819712424700284. The work was supported by federal budget funds within the framework of the state assignment of the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences (No. FWNR-2022-0023).",

year = "2025",

month = mar,

day = "18",

doi = "10.1134/S1819712424700284",

language = "English",

volume = "18",

pages = "643--648",

journal = "Neurochemical Journal",

issn = "1819-7124",

publisher = "Общество с ограниченной ответственностью Международная академическая издательская компания {"}Наука/Интерпериодика{"}",

number = "4",

}

RIS

TY - JOUR

T1 - Dexamethasone Reduces Cytokine mRNA Levels and Microglial Activity in the Brainstem of Newborn Rats

AU - Kalinina, T. s.

AU - Bulygina, V. v.

AU - Lanshakov, D. a.

AU - Sukhareva, E. v.

AU - Dygalo, N. n.

N1 - Dexamethasone Reduces Cytokine mRNA Levels and Microglial Activity in the Brainstem of Newborn Rats / T. S. Kalinina, V. V. Bulygina, D. A. Lanshakov [et al.] // Neurochemical Journal. – 2024. – Vol. 18, No. 4. – P. 643-648. – DOI 10.1134/S1819712424700284. The work was supported by federal budget funds within the framework of the state assignment of the Institute of Cytology and Genetics of the Siberian Branch of the Russian Academy of Sciences (No. FWNR-2022-0023).

PY - 2025/3/18

Y1 - 2025/3/18

N2 - During the perinatal period of ontogeny, microglia performs functions of a critical key-regulator of the angio-, neuro-, and synaptogenesis processes. Under normal development, without inflammation induction, administration of the glucocorticoid hormone dexamethasone (0.2 mg/kg) caused a rapid decrease in the mRNA levels of both pro- and anti-inflammatory cytokines in the brainstem of neonatal rat pups. A decrease in the expression of the Il1b and Tnfa genes was observed within 1 h, and Il10 and Tgfb1, 4 h after the administration of the hormone to 3-day-old rat pups. Suppression of cytokine mRNA levels was accompanied by a decrease in the number of cells expressing the microglia marker protein IBA1 in the locus coeruleus region of the brainstem in 6 h after glucocorticoid administration. The identified features of the dexamethasone action can weaken the participation of microglia in the processes of neuroplasticity in the developing brain, which may be one of the reasons for long-term changes in brain functioning.

AB - During the perinatal period of ontogeny, microglia performs functions of a critical key-regulator of the angio-, neuro-, and synaptogenesis processes. Under normal development, without inflammation induction, administration of the glucocorticoid hormone dexamethasone (0.2 mg/kg) caused a rapid decrease in the mRNA levels of both pro- and anti-inflammatory cytokines in the brainstem of neonatal rat pups. A decrease in the expression of the Il1b and Tnfa genes was observed within 1 h, and Il10 and Tgfb1, 4 h after the administration of the hormone to 3-day-old rat pups. Suppression of cytokine mRNA levels was accompanied by a decrease in the number of cells expressing the microglia marker protein IBA1 in the locus coeruleus region of the brainstem in 6 h after glucocorticoid administration. The identified features of the dexamethasone action can weaken the participation of microglia in the processes of neuroplasticity in the developing brain, which may be one of the reasons for long-term changes in brain functioning.

UR - https://www.elibrary.ru/item.asp?id=80497963

U2 - 10.1134/S1819712424700284

DO - 10.1134/S1819712424700284

M3 - Article

VL - 18

SP - 643

EP - 648

JO - Neurochemical Journal

JF - Neurochemical Journal

SN - 1819-7124

IS - 4

ER -

ID: 67760386