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Development of multifunctional Overhauser-enhanced magnetic resonance imaging for concurrent in vivo mapping of tumor interstitial oxygenation, acidosis and inorganic phosphate concentration. / Gorodetskii, Artem A.; Eubank, Timothy D.; Driesschaert, Benoit и др.

в: Scientific Reports, Том 9, № 1, 12093, 20.08.2019, стр. 12093.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Gorodetskii, AA, Eubank, TD, Driesschaert, B, Poncelet, M, Ellis, E, Khramtsov, VV & Bobko, AA 2019, 'Development of multifunctional Overhauser-enhanced magnetic resonance imaging for concurrent in vivo mapping of tumor interstitial oxygenation, acidosis and inorganic phosphate concentration', Scientific Reports, Том. 9, № 1, 12093, стр. 12093. https://doi.org/10.1038/s41598-019-48524-3

APA

Gorodetskii, A. A., Eubank, T. D., Driesschaert, B., Poncelet, M., Ellis, E., Khramtsov, V. V., & Bobko, A. A. (2019). Development of multifunctional Overhauser-enhanced magnetic resonance imaging for concurrent in vivo mapping of tumor interstitial oxygenation, acidosis and inorganic phosphate concentration. Scientific Reports, 9(1), 12093. [12093]. https://doi.org/10.1038/s41598-019-48524-3

Vancouver

Gorodetskii AA, Eubank TD, Driesschaert B, Poncelet M, Ellis E, Khramtsov VV и др. Development of multifunctional Overhauser-enhanced magnetic resonance imaging for concurrent in vivo mapping of tumor interstitial oxygenation, acidosis and inorganic phosphate concentration. Scientific Reports. 2019 авг. 20;9(1):12093. 12093. doi: 10.1038/s41598-019-48524-3

Author

Gorodetskii, Artem A. ; Eubank, Timothy D. ; Driesschaert, Benoit и др. / Development of multifunctional Overhauser-enhanced magnetic resonance imaging for concurrent in vivo mapping of tumor interstitial oxygenation, acidosis and inorganic phosphate concentration. в: Scientific Reports. 2019 ; Том 9, № 1. стр. 12093.

BibTeX

@article{0c0d41e5ec854fa7b34c754b18a0390f,
title = "Development of multifunctional Overhauser-enhanced magnetic resonance imaging for concurrent in vivo mapping of tumor interstitial oxygenation, acidosis and inorganic phosphate concentration",
abstract = "Tumor oxygenation (pO2), acidosis (pH) and interstitial inorganic phosphate concentration (Pi) are important parameters of the malignant behavior of cancer. A noninvasive procedure that enables visualization of these parameters may provide unique information about mechanisms of tumor pathophysiology and provide clues to new treatment targets. In this research, we present a multiparametric imaging method allowing for concurrent mapping of pH, spin probe concentration, pO2, and Pi using a single contrast agent and Overhauser-enhanced magnetic resonance imaging technique. The developed approach was applied to concurrent multifunctional imaging in phantom samples and in vivo in a mouse model of breast cancer. Tumor tissues showed higher heterogeneity of the distributions of the parameters compared with normal mammary gland and demonstrated the areas of significant acidosis, hypoxia, and elevated Pi content.",
keywords = "TISSUE OXYGEN, MRI, SPECTROSCOPY, OXIMETRY, PROBES",
author = "Gorodetskii, {Artem A.} and Eubank, {Timothy D.} and Benoit Driesschaert and Martin Poncelet and Emily Ellis and Khramtsov, {Valery V.} and Bobko, {Andrey A.}",
year = "2019",
month = aug,
day = "20",
doi = "10.1038/s41598-019-48524-3",
language = "English",
volume = "9",
pages = "12093",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Development of multifunctional Overhauser-enhanced magnetic resonance imaging for concurrent in vivo mapping of tumor interstitial oxygenation, acidosis and inorganic phosphate concentration

AU - Gorodetskii, Artem A.

AU - Eubank, Timothy D.

AU - Driesschaert, Benoit

AU - Poncelet, Martin

AU - Ellis, Emily

AU - Khramtsov, Valery V.

AU - Bobko, Andrey A.

PY - 2019/8/20

Y1 - 2019/8/20

N2 - Tumor oxygenation (pO2), acidosis (pH) and interstitial inorganic phosphate concentration (Pi) are important parameters of the malignant behavior of cancer. A noninvasive procedure that enables visualization of these parameters may provide unique information about mechanisms of tumor pathophysiology and provide clues to new treatment targets. In this research, we present a multiparametric imaging method allowing for concurrent mapping of pH, spin probe concentration, pO2, and Pi using a single contrast agent and Overhauser-enhanced magnetic resonance imaging technique. The developed approach was applied to concurrent multifunctional imaging in phantom samples and in vivo in a mouse model of breast cancer. Tumor tissues showed higher heterogeneity of the distributions of the parameters compared with normal mammary gland and demonstrated the areas of significant acidosis, hypoxia, and elevated Pi content.

AB - Tumor oxygenation (pO2), acidosis (pH) and interstitial inorganic phosphate concentration (Pi) are important parameters of the malignant behavior of cancer. A noninvasive procedure that enables visualization of these parameters may provide unique information about mechanisms of tumor pathophysiology and provide clues to new treatment targets. In this research, we present a multiparametric imaging method allowing for concurrent mapping of pH, spin probe concentration, pO2, and Pi using a single contrast agent and Overhauser-enhanced magnetic resonance imaging technique. The developed approach was applied to concurrent multifunctional imaging in phantom samples and in vivo in a mouse model of breast cancer. Tumor tissues showed higher heterogeneity of the distributions of the parameters compared with normal mammary gland and demonstrated the areas of significant acidosis, hypoxia, and elevated Pi content.

KW - TISSUE OXYGEN

KW - MRI

KW - SPECTROSCOPY

KW - OXIMETRY

KW - PROBES

UR - http://www.scopus.com/inward/record.url?scp=85070819729&partnerID=8YFLogxK

U2 - 10.1038/s41598-019-48524-3

DO - 10.1038/s41598-019-48524-3

M3 - Article

C2 - 31431629

AN - SCOPUS:85070819729

VL - 9

SP - 12093

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 12093

ER -

ID: 21256864