TY - JOUR

T1 - Determination of the Microelement Composition of Biopsy Material of Red Bone Marrow in Patients with Hemoblastoses by the SR–XRF Method

AU - Trunova, V. A.

AU - Pospelova, T. I.

AU - Voytko, M. S.

AU - Krupovich, E. S.

AU - Soldatova, G. S.

AU - Kuzmin, R. O.

AU - Tsigulev, K. S.

N1 - The development of the method for sample preparation of whole red bone marrow for SRXRF was supported by the Ministry of Science and Higher Education of the Russian Federation within the governmental order for SRF SKIF Boreskov Institute of Catalysis (project FWUR-2024-0040). Elemental analysis of biopsy material of red bone marrow of patients with hemoblastoses by the SRXRF method was carried out with the support of the Ministry of Science and Higher Education of the Russian Federation (project no. 121031700314-5). Determination of the Microelement Composition of Biopsy Material of Red Bone Marrow in Patients with Hemoblastoses by the SR–XRF Method / V. A. Trunova, T. I. Pospelova, M. S. Voytko [et al.] // Journal of Surface Investigation: X-Ray, Synchrotron and Neutron Techniques. – 2025. – Vol. 19, No. 1. – P. 218-223. – DOI 10.1134/S1027451025700326.

PY - 2025/6/25

Y1 - 2025/6/25

N2 - Abstract: Personalized medicine is a modern concept aimed at individualization of patient therapy. The relevance of the search and identification of new highly sensitive and specific prognostic markers in patients with hemoblastoses is due to the leading positions in the incidence and mortality rate among young working-age population, which gives the problem special socio-economic significance. The study is aimed at studying the content of trace elements in biopsy material (red bone marrow) of patients with hemoblastoses at the onset of the disease and after chemoradiation therapy. Using the method of X-ray fluorescence analysis and synchrotron radiation, it is possible to simultaneously determine more than 25 chemical elements in a low-mass sample with non-destructive sample preparation. Difference in the concentrations of 10 elements (S, K, Ca, Cu, Zn, Fe, Se, Br, Rb, and Cd) in patients with two pathologies, lymphoma and leukemia, is considered.

AB - Abstract: Personalized medicine is a modern concept aimed at individualization of patient therapy. The relevance of the search and identification of new highly sensitive and specific prognostic markers in patients with hemoblastoses is due to the leading positions in the incidence and mortality rate among young working-age population, which gives the problem special socio-economic significance. The study is aimed at studying the content of trace elements in biopsy material (red bone marrow) of patients with hemoblastoses at the onset of the disease and after chemoradiation therapy. Using the method of X-ray fluorescence analysis and synchrotron radiation, it is possible to simultaneously determine more than 25 chemical elements in a low-mass sample with non-destructive sample preparation. Difference in the concentrations of 10 elements (S, K, Ca, Cu, Zn, Fe, Se, Br, Rb, and Cd) in patients with two pathologies, lymphoma and leukemia, is considered.

KW - X-ray fluorescence analysis

KW - acute leukemia

KW - biopsy material

KW - hemoblastoses

KW - lymphoma

KW - personalized medicine

KW - red bone marrow

KW - synchrotron radiation

KW - trace elements

UR - https://www.mendeley.com/catalogue/e866e8c4-d88f-3d45-9b63-0fab0b02e891/

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105009351607&origin=inward

UR - https://www.elibrary.ru/item.asp?id=82550169

U2 - 10.1134/S1027451025700326

DO - 10.1134/S1027451025700326

M3 - Article

VL - 19

SP - 218

EP - 223

JO - Journal of Surface Investigation

JF - Journal of Surface Investigation

SN - 1027-4510

IS - 1

ER -