TY - JOUR

T1 - Delayed effects of neonatal immune activation on brain neurochemistry and hypothalamic–pituitary–adrenal axis functioning

AU - Khantakova, Julia N.

AU - Bondar, Natalia P.

AU - Sapronova, Anna A.

AU - Reshetnikov, Vasiliy V.

N1 - Funding Information: This study was supported by publicly funded project FWNR‐2022‐0016 (Russia). Publisher Copyright: © 2022 Federation of European Neuroscience Societies and John Wiley & Sons Ltd.

PY - 2022/11

Y1 - 2022/11

N2 - During the postnatal period, the brain is highly sensitive to stress and inflammation, which are hazardous to normal growth and development. There is increasing evidence that inflammatory processes in the early postnatal period increase the risk of psychopathologies and cognitive impairment later in life. On the other hand, there are few studies on the ability of infectious agents to cause long-term neuroinflammation, leading to changes in the hypothalamic–pituitary–adrenal axis functioning and an imbalance in the neurotransmitter system. In this review, we examine short- and long-term effects of neonatal-induced inflammation in rodents on glutamatergic, GABAergic and monoaminergic systems and on hypothalamic–pituitary–adrenal axis activity.

AB - During the postnatal period, the brain is highly sensitive to stress and inflammation, which are hazardous to normal growth and development. There is increasing evidence that inflammatory processes in the early postnatal period increase the risk of psychopathologies and cognitive impairment later in life. On the other hand, there are few studies on the ability of infectious agents to cause long-term neuroinflammation, leading to changes in the hypothalamic–pituitary–adrenal axis functioning and an imbalance in the neurotransmitter system. In this review, we examine short- and long-term effects of neonatal-induced inflammation in rodents on glutamatergic, GABAergic and monoaminergic systems and on hypothalamic–pituitary–adrenal axis activity.

KW - HPA axis

KW - LPS

KW - neonatal immune activation

KW - neurochemistry

UR - http://www.scopus.com/inward/record.url?scp=85139766056&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/84714eb9-6475-35bc-b1c2-26b2003acad8/

U2 - 10.1111/ejn.15831

DO - 10.1111/ejn.15831

M3 - Review article

C2 - 36156830

AN - SCOPUS:85139766056

VL - 56

SP - 5931

EP - 5951

JO - European Journal of Neuroscience

JF - European Journal of Neuroscience

SN - 0953-816X

IS - 10

ER -