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Dataset for dynamics and conformational changes in human NEIL2 protein analyzed by integrative structural biology approach. / Zhdanova, Polina V.; Ishchenko, Alexander A.; Chernonosov, Alexander A. и др.

в: Data in Brief, Том 40, 107760, 02.2022.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Zhdanova, PV, Ishchenko, AA, Chernonosov, AA, Zharkov, DO & Koval, VV 2022, 'Dataset for dynamics and conformational changes in human NEIL2 protein analyzed by integrative structural biology approach', Data in Brief, Том. 40, 107760. https://doi.org/10.1016/j.dib.2021.107760

APA

Zhdanova, P. V., Ishchenko, A. A., Chernonosov, A. A., Zharkov, D. O., & Koval, V. V. (2022). Dataset for dynamics and conformational changes in human NEIL2 protein analyzed by integrative structural biology approach. Data in Brief, 40, [107760]. https://doi.org/10.1016/j.dib.2021.107760

Vancouver

Zhdanova PV, Ishchenko AA, Chernonosov AA, Zharkov DO, Koval VV. Dataset for dynamics and conformational changes in human NEIL2 protein analyzed by integrative structural biology approach. Data in Brief. 2022 февр.;40:107760. doi: 10.1016/j.dib.2021.107760

Author

Zhdanova, Polina V. ; Ishchenko, Alexander A. ; Chernonosov, Alexander A. и др. / Dataset for dynamics and conformational changes in human NEIL2 protein analyzed by integrative structural biology approach. в: Data in Brief. 2022 ; Том 40.

BibTeX

@article{dcb9d7084e4949489236de06d4470c75,
title = "Dataset for dynamics and conformational changes in human NEIL2 protein analyzed by integrative structural biology approach",
abstract = "This work presents new data on human endonuclease VIII-like 2 protein (hNEIL2), a part of DNA glycosylases of the helix–two-turn–helix structural superfamily. While X-ray structure of oNEIL2 (opossum Monodelphis) was resolved partially [1], the structure of hNEIL2 has not yet been determined. This data article describes a powerful combination of hydrogen-deuterium exchange mass spectrometry, homology modeling, and molecular dynamics simulations for protein conformational dynamics analysis. The data supplied in this work are related to the research article entitled “Dynamics and Conformational Changes in Human NEIL2 DNA Glycosylase Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry”.",
keywords = "Base excision repair, DNA damage, DNA glycosylases, DNA repair, HDX-MS, Molecular dynamics, NEIL2, Structural dynamics",
author = "Zhdanova, {Polina V.} and Ishchenko, {Alexander A.} and Chernonosov, {Alexander A.} and Zharkov, {Dmitry O.} and Koval, {Vladimir V.}",
note = "Funding Information: This research was supported by Grant No. 20-14-00214 of the Russian Science Foundation . We thank Dr. S{\'e}bastien Brier for his valuable assistance in HDX-MS sample preparation and data acquisition and the Institut Pasteur Biological NMR Technological Platform for access to the HDX-MS instrument. Publisher Copyright: {\textcopyright} 2021",
year = "2022",
month = feb,
doi = "10.1016/j.dib.2021.107760",
language = "English",
volume = "40",
journal = "Data in Brief",
issn = "2352-3409",
publisher = "Elsevier",

}

RIS

TY - JOUR

T1 - Dataset for dynamics and conformational changes in human NEIL2 protein analyzed by integrative structural biology approach

AU - Zhdanova, Polina V.

AU - Ishchenko, Alexander A.

AU - Chernonosov, Alexander A.

AU - Zharkov, Dmitry O.

AU - Koval, Vladimir V.

N1 - Funding Information: This research was supported by Grant No. 20-14-00214 of the Russian Science Foundation . We thank Dr. Sébastien Brier for his valuable assistance in HDX-MS sample preparation and data acquisition and the Institut Pasteur Biological NMR Technological Platform for access to the HDX-MS instrument. Publisher Copyright: © 2021

PY - 2022/2

Y1 - 2022/2

N2 - This work presents new data on human endonuclease VIII-like 2 protein (hNEIL2), a part of DNA glycosylases of the helix–two-turn–helix structural superfamily. While X-ray structure of oNEIL2 (opossum Monodelphis) was resolved partially [1], the structure of hNEIL2 has not yet been determined. This data article describes a powerful combination of hydrogen-deuterium exchange mass spectrometry, homology modeling, and molecular dynamics simulations for protein conformational dynamics analysis. The data supplied in this work are related to the research article entitled “Dynamics and Conformational Changes in Human NEIL2 DNA Glycosylase Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry”.

AB - This work presents new data on human endonuclease VIII-like 2 protein (hNEIL2), a part of DNA glycosylases of the helix–two-turn–helix structural superfamily. While X-ray structure of oNEIL2 (opossum Monodelphis) was resolved partially [1], the structure of hNEIL2 has not yet been determined. This data article describes a powerful combination of hydrogen-deuterium exchange mass spectrometry, homology modeling, and molecular dynamics simulations for protein conformational dynamics analysis. The data supplied in this work are related to the research article entitled “Dynamics and Conformational Changes in Human NEIL2 DNA Glycosylase Analyzed by Hydrogen/Deuterium Exchange Mass Spectrometry”.

KW - Base excision repair

KW - DNA damage

KW - DNA glycosylases

KW - DNA repair

KW - HDX-MS

KW - Molecular dynamics

KW - NEIL2

KW - Structural dynamics

UR - http://www.scopus.com/inward/record.url?scp=85121788925&partnerID=8YFLogxK

U2 - 10.1016/j.dib.2021.107760

DO - 10.1016/j.dib.2021.107760

M3 - Article

C2 - 35005149

AN - SCOPUS:85121788925

VL - 40

JO - Data in Brief

JF - Data in Brief

SN - 2352-3409

M1 - 107760

ER -

ID: 35198997