TY - JOUR

T1 - Cytokine variations within brain structures in rats selected for differences in aggression

AU - Alperina, Elizaveta

AU - Idova, Galina

AU - Zhukova, Elena

AU - Zhanaeva, Svetlana

AU - Kozhemyakina, Rimma

N1 - Copyright © 2018 Elsevier B.V. All rights reserved.

PY - 2019/1/23

Y1 - 2019/1/23

N2 - The present study examined the content of cytokines (IL-1β IL-2, IL-6, IL-10) in the brain structures (the hypothalamus, striatum, frontal cortex, and hippocampus) in two rat lines selected for differences in fear-induced aggression at 2, 4, and 24 h after a peripheral injection of saline or lipopolysaccharide (LPS, 250 μg/kg). LPS stimulation elevated cytokine activity above baseline levels in both aggressive and nonaggressive rats, but the pattern, time course of cytokine changes, and their regional characteristics varied according to the animal aggressiveness. After LPS administration, aggressive rats showed increased levels of IL-1β in the hypothalamus at 2 and 4 h and in the frontal cortex at 4 and 24 h compared to LPS-treated nonaggressive line. IL-2 was increased in the frontal cortex and striatum of aggressive rats within 24 h, while IL-6 elevation in the hypothalamus was found at 4 h and in the frontal cortex at 2 and 4 h. In the hippocampus, the levels of IL-1β IL-2, and IL-6 were lower in LPS-treated aggressive rats than in nonaggressive animals. The levels of anti-inflammatory cytokine IL-10 were also decreased in all brain structures of aggressive rats receiving LPS. The results indicate that genetic predisposition to increased aggression is associated with a time and region-dependent changes in the levels of pro- and anti-inflammatory cytokines.

AB - The present study examined the content of cytokines (IL-1β IL-2, IL-6, IL-10) in the brain structures (the hypothalamus, striatum, frontal cortex, and hippocampus) in two rat lines selected for differences in fear-induced aggression at 2, 4, and 24 h after a peripheral injection of saline or lipopolysaccharide (LPS, 250 μg/kg). LPS stimulation elevated cytokine activity above baseline levels in both aggressive and nonaggressive rats, but the pattern, time course of cytokine changes, and their regional characteristics varied according to the animal aggressiveness. After LPS administration, aggressive rats showed increased levels of IL-1β in the hypothalamus at 2 and 4 h and in the frontal cortex at 4 and 24 h compared to LPS-treated nonaggressive line. IL-2 was increased in the frontal cortex and striatum of aggressive rats within 24 h, while IL-6 elevation in the hypothalamus was found at 4 h and in the frontal cortex at 2 and 4 h. In the hippocampus, the levels of IL-1β IL-2, and IL-6 were lower in LPS-treated aggressive rats than in nonaggressive animals. The levels of anti-inflammatory cytokine IL-10 were also decreased in all brain structures of aggressive rats receiving LPS. The results indicate that genetic predisposition to increased aggression is associated with a time and region-dependent changes in the levels of pro- and anti-inflammatory cytokines.

KW - Brain structures

KW - Genetically defined fear-induced aggression

KW - LPS

KW - Pro- and anti-inflammatory cytokines

KW - HOSTILITY

KW - BEHAVIOR

KW - MONOCYTES

KW - RECEPTOR

KW - INTERLEUKIN-10

KW - RESPONSES

KW - SPLEEN

KW - SEROTONIN

KW - STRESS

KW - EXPRESSION

KW - Cytokines/immunology

KW - Male

KW - Interleukin-2/immunology

KW - Interleukin-6/immunology

KW - Brain/immunology

KW - Interleukin-10/immunology

KW - Interleukin-1beta/immunology

KW - Inflammation/chemically induced

KW - Rats

KW - Lipopolysaccharides/administration & dosage

KW - Animals

KW - Aggression/physiology

UR - http://www.scopus.com/inward/record.url?scp=85056660582&partnerID=8YFLogxK

U2 - 10.1016/j.neulet.2018.11.012

DO - 10.1016/j.neulet.2018.11.012

M3 - Article

C2 - 30423398

AN - SCOPUS:85056660582

VL - 692

SP - 193

EP - 198

JO - Neuroscience Letters

JF - Neuroscience Letters

SN - 0304-3940

ER -