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Cytokine Production by Splenic Cells in C57BL/6J Mice with Depression-Like Behavior Depends on the Duration of Social Stress. / Idova, G. V.; Markova, E. V.; Gevorgyan, M. M. и др.

в: Bulletin of Experimental Biology and Medicine, Том 164, № 5, 03.2018, стр. 645-649.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Idova, GV, Markova, EV, Gevorgyan, MM, Al’perina, EL & Zhanaeva, SY 2018, 'Cytokine Production by Splenic Cells in C57BL/6J Mice with Depression-Like Behavior Depends on the Duration of Social Stress', Bulletin of Experimental Biology and Medicine, Том. 164, № 5, стр. 645-649. https://doi.org/10.1007/s10517-018-4050-9

APA

Idova, G. V., Markova, E. V., Gevorgyan, M. M., Al’perina, E. L., & Zhanaeva, S. Y. (2018). Cytokine Production by Splenic Cells in C57BL/6J Mice with Depression-Like Behavior Depends on the Duration of Social Stress. Bulletin of Experimental Biology and Medicine, 164(5), 645-649. https://doi.org/10.1007/s10517-018-4050-9

Vancouver

Idova GV, Markova EV, Gevorgyan MM, Al’perina EL, Zhanaeva SY. Cytokine Production by Splenic Cells in C57BL/6J Mice with Depression-Like Behavior Depends on the Duration of Social Stress. Bulletin of Experimental Biology and Medicine. 2018 март;164(5):645-649. doi: 10.1007/s10517-018-4050-9

Author

Idova, G. V. ; Markova, E. V. ; Gevorgyan, M. M. и др. / Cytokine Production by Splenic Cells in C57BL/6J Mice with Depression-Like Behavior Depends on the Duration of Social Stress. в: Bulletin of Experimental Biology and Medicine. 2018 ; Том 164, № 5. стр. 645-649.

BibTeX

@article{ae50aa2259424c61894bd6c669a2d4db,
title = "Cytokine Production by Splenic Cells in C57BL/6J Mice with Depression-Like Behavior Depends on the Duration of Social Stress",
abstract = "We studied the influence of depression-like behavior developed in C57BL/6J mice under conditions of social stress of different duration on cytokine production by splenic cells. Imbalance of the pro- and anti-inflammatory cytokines was detected at the early stage of depression-like behavior (10-day experience of defeats): increased production of proinflammatory IL-2 and IL-6 cytokines along with a decrease in anti-inflammatory IL-10 level; the levels of IL-1β, TNFα, IFNγ, and IL-4 remained unaffected. At later terms (20 days of confrontations), we revealed more pronounced changes in spontaneous production of proinflammatory cytokines that were not detected after shorter social stress. These findings suggest that cytokine profile depends on duration of social stress. Possible mechanisms of cytokine production during formation of depression-like state are discussed.",
keywords = "depression-like behavior, duration of social stress, pro- and anti-inflammatory cytokines, splenic cells, ANTIDEPRESSANTS, MECHANISMS, STRAIN",
author = "Idova, {G. V.} and Markova, {E. V.} and Gevorgyan, {M. M.} and Al{\textquoteright}perina, {E. L.} and Zhanaeva, {S. Y.}",
year = "2018",
month = mar,
doi = "10.1007/s10517-018-4050-9",
language = "English",
volume = "164",
pages = "645--649",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "5",

}

RIS

TY - JOUR

T1 - Cytokine Production by Splenic Cells in C57BL/6J Mice with Depression-Like Behavior Depends on the Duration of Social Stress

AU - Idova, G. V.

AU - Markova, E. V.

AU - Gevorgyan, M. M.

AU - Al’perina, E. L.

AU - Zhanaeva, S. Y.

PY - 2018/3

Y1 - 2018/3

N2 - We studied the influence of depression-like behavior developed in C57BL/6J mice under conditions of social stress of different duration on cytokine production by splenic cells. Imbalance of the pro- and anti-inflammatory cytokines was detected at the early stage of depression-like behavior (10-day experience of defeats): increased production of proinflammatory IL-2 and IL-6 cytokines along with a decrease in anti-inflammatory IL-10 level; the levels of IL-1β, TNFα, IFNγ, and IL-4 remained unaffected. At later terms (20 days of confrontations), we revealed more pronounced changes in spontaneous production of proinflammatory cytokines that were not detected after shorter social stress. These findings suggest that cytokine profile depends on duration of social stress. Possible mechanisms of cytokine production during formation of depression-like state are discussed.

AB - We studied the influence of depression-like behavior developed in C57BL/6J mice under conditions of social stress of different duration on cytokine production by splenic cells. Imbalance of the pro- and anti-inflammatory cytokines was detected at the early stage of depression-like behavior (10-day experience of defeats): increased production of proinflammatory IL-2 and IL-6 cytokines along with a decrease in anti-inflammatory IL-10 level; the levels of IL-1β, TNFα, IFNγ, and IL-4 remained unaffected. At later terms (20 days of confrontations), we revealed more pronounced changes in spontaneous production of proinflammatory cytokines that were not detected after shorter social stress. These findings suggest that cytokine profile depends on duration of social stress. Possible mechanisms of cytokine production during formation of depression-like state are discussed.

KW - depression-like behavior

KW - duration of social stress

KW - pro- and anti-inflammatory cytokines

KW - splenic cells

KW - ANTIDEPRESSANTS

KW - MECHANISMS

KW - STRAIN

UR - http://www.scopus.com/inward/record.url?scp=85044390038&partnerID=8YFLogxK

U2 - 10.1007/s10517-018-4050-9

DO - 10.1007/s10517-018-4050-9

M3 - Article

C2 - 29577194

AN - SCOPUS:85044390038

VL - 164

SP - 645

EP - 649

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 5

ER -

ID: 12178849