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Cytokine Content in the Hypothalamus and Hippocampus of C57Bl/6J Mice with Depressive-Like Behavior. / Idova, G. V.; Al’perina, E. L.; Zhanaeva, S. Ya и др.

в: Bulletin of Experimental Biology and Medicine, Том 167, № 1, 15.05.2019, стр. 11-16.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Idova, GV, Al’perina, EL, Zhanaeva, SY, Gevorgyan, MM & Rogozhnikova, AA 2019, 'Cytokine Content in the Hypothalamus and Hippocampus of C57Bl/6J Mice with Depressive-Like Behavior', Bulletin of Experimental Biology and Medicine, Том. 167, № 1, стр. 11-16. https://doi.org/10.1007/s10517-019-04450-y

APA

Idova, G. V., Al’perina, E. L., Zhanaeva, S. Y., Gevorgyan, M. M., & Rogozhnikova, A. A. (2019). Cytokine Content in the Hypothalamus and Hippocampus of C57Bl/6J Mice with Depressive-Like Behavior. Bulletin of Experimental Biology and Medicine, 167(1), 11-16. https://doi.org/10.1007/s10517-019-04450-y

Vancouver

Idova GV, Al’perina EL, Zhanaeva SY, Gevorgyan MM, Rogozhnikova AA. Cytokine Content in the Hypothalamus and Hippocampus of C57Bl/6J Mice with Depressive-Like Behavior. Bulletin of Experimental Biology and Medicine. 2019 май 15;167(1):11-16. doi: 10.1007/s10517-019-04450-y

Author

Idova, G. V. ; Al’perina, E. L. ; Zhanaeva, S. Ya и др. / Cytokine Content in the Hypothalamus and Hippocampus of C57Bl/6J Mice with Depressive-Like Behavior. в: Bulletin of Experimental Biology and Medicine. 2019 ; Том 167, № 1. стр. 11-16.

BibTeX

@article{6705073ef0c5482f9b6bb317a9aa7904,
title = "Cytokine Content in the Hypothalamus and Hippocampus of C57Bl/6J Mice with Depressive-Like Behavior",
abstract = "The content of pro- and anti-inflammatory cytokines in the hypothalamus, hippocampus, and blood serum of C57Bl/6J mice with depressive-like behavior induced by 20-day social stress was analyzed in 4 h after immune stimulation with LPS (250 μg/kg). These animals are characterized by a tendency to an increase in the blood content of IL-6 and a decrease in the level of IL-10. Changes in cytokine content in the brain of mice with depressive-like state developed under these conditions were observed only in the hippocampus: the levels of IL-1β, IL-6, TNFα, and IL-10 increased and the content of IFNγ decreased in comparison the corresponding parameters in the controls (not exposed to social stress) and aggressive animals. No changes in the levels of IL-2, IL-4, and IL-17 were revealed in the hypothalamus and hippocampus.",
keywords = "depressive-like behavior, hippocampus, hypothalamus, pro- and anti-inflammatory cytokines, social stress, MECHANISMS",
author = "Idova, {G. V.} and Al{\textquoteright}perina, {E. L.} and Zhanaeva, {S. Ya} and Gevorgyan, {M. M.} and Rogozhnikova, {A. A.}",
year = "2019",
month = may,
day = "15",
doi = "10.1007/s10517-019-04450-y",
language = "English",
volume = "167",
pages = "11--16",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "1",

}

RIS

TY - JOUR

T1 - Cytokine Content in the Hypothalamus and Hippocampus of C57Bl/6J Mice with Depressive-Like Behavior

AU - Idova, G. V.

AU - Al’perina, E. L.

AU - Zhanaeva, S. Ya

AU - Gevorgyan, M. M.

AU - Rogozhnikova, A. A.

PY - 2019/5/15

Y1 - 2019/5/15

N2 - The content of pro- and anti-inflammatory cytokines in the hypothalamus, hippocampus, and blood serum of C57Bl/6J mice with depressive-like behavior induced by 20-day social stress was analyzed in 4 h after immune stimulation with LPS (250 μg/kg). These animals are characterized by a tendency to an increase in the blood content of IL-6 and a decrease in the level of IL-10. Changes in cytokine content in the brain of mice with depressive-like state developed under these conditions were observed only in the hippocampus: the levels of IL-1β, IL-6, TNFα, and IL-10 increased and the content of IFNγ decreased in comparison the corresponding parameters in the controls (not exposed to social stress) and aggressive animals. No changes in the levels of IL-2, IL-4, and IL-17 were revealed in the hypothalamus and hippocampus.

AB - The content of pro- and anti-inflammatory cytokines in the hypothalamus, hippocampus, and blood serum of C57Bl/6J mice with depressive-like behavior induced by 20-day social stress was analyzed in 4 h after immune stimulation with LPS (250 μg/kg). These animals are characterized by a tendency to an increase in the blood content of IL-6 and a decrease in the level of IL-10. Changes in cytokine content in the brain of mice with depressive-like state developed under these conditions were observed only in the hippocampus: the levels of IL-1β, IL-6, TNFα, and IL-10 increased and the content of IFNγ decreased in comparison the corresponding parameters in the controls (not exposed to social stress) and aggressive animals. No changes in the levels of IL-2, IL-4, and IL-17 were revealed in the hypothalamus and hippocampus.

KW - depressive-like behavior

KW - hippocampus

KW - hypothalamus

KW - pro- and anti-inflammatory cytokines

KW - social stress

KW - MECHANISMS

UR - http://www.scopus.com/inward/record.url?scp=85067960618&partnerID=8YFLogxK

U2 - 10.1007/s10517-019-04450-y

DO - 10.1007/s10517-019-04450-y

M3 - Article

C2 - 31177464

AN - SCOPUS:85067960618

VL - 167

SP - 11

EP - 16

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 1

ER -

ID: 20707641