TY - JOUR

T1 - Cu(II), Co(II), Mn(II) complexes with 5-phenyltetrazole and polypyridyl ligands: Synthesis, characterization and evaluation of the cytotoxicity and antimicrobial activity

AU - Eremina, Julia A.

AU - Ermakova, Ekaterina A.

AU - Smirnova, Ksenia S.

AU - Klyushova, Lyubov S.

AU - Berezin, Alexey S.

AU - Sukhikh, Taisiya S.

AU - Zubenko, Alexander A.

AU - Fetisov, Leonid N.

AU - Kononenko, Kristina N.

AU - Lider, Elizaveta V.

N1 - Funding Information: This work was supported by the Russian Science Foundation (Project № 20-73-10207 ). Funding Information: This work was supported by the Russian Science Foundation (Project ? 20-73-10207). The authors thank Anna P. Zubareva and Natalia N. Komardina for the elemental analysis, Anastasia O. Matveeva for the X-ray phase analysis data, Evgeniy V. Korotaev for magnetochemical measurements, Alexander S. Sukhikh, Vladislav Yu. Komarov and Polina S. Serebrennikova for providing the data collected in XRD Facility of NIIC SB RAS. This work involved the use of equipment from the ?Proteomic analysis? Center of the Institute of Molecular Biology and Biophysics of Federal State Budget Scientific Institution ?Federal Research Centre of Fundamental and Translational Medicine? (IMBB FRC FTM), Novosibirsk, Russia. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/9/15

Y1 - 2021/9/15

N2 - In this work, six new mixed-ligand Cu(II), Co(II), Mn(II) complexes with 5-phenyltetrazole (HL) and polypyridine ligands (phen – 1,10-phenanthroline, dmbipy – 2,2′-bi-4-picoline, dmphen – 4,7-dimethyl-1,10-phenanthroline, phendione – 1,10-phenanthroline-5,6-dione), namely, [Cu(dmbipy)(L)2] (1), [Cu2(dmphen)2(L)4] (2), [Cu(phendione)(L)2] (3), [Co3(phen)2(L)6] (4), [Mn3(phen)2(L)4(OAc)2] (5), [Mn(H2O)4(phen)]·phen·2L (6), are reported. Complexes have been characterized by EPR and IR-spectroscopy, elemental, thermogravimetric and powder X-ray diffraction analysis. Molecular structures of [Cu(dmphen)2L]·L·6H2O (2a), [Co3(phen)2(HL)2(L)4(OH)2]·1.9EtOH·1.1DMSO (4a), [Mn3(phen)2(L)4(OAc)2]·H2O (5·H2O) and [Mn(H2O)4(phen)]·phen·2L (6) have been determined by single crystal X–ray diffraction. The UV–vis spectroscopy has been applied to study the behavior of the compounds in solution. All complexes have been screened in vitro for their cytotoxic activity against human cancer cell lines: larynx carcinoma (Hep2), hepatocellular carcinoma (HepG2) and breast adenocarcinoma (MCF-7). Cu(II) complexes exhibit significant dose-dependent cytotoxic effect: [Cu2(dmphen)2(L)4] (2), [Cu(phendione)(L)2] (3) are found to be the most cytotoxic. The antimicrobial activity of complexes and ligands has been investigated against Escherichia coli, Staphylococcus aureus, Penicillium italicum and Colpoda steinii.

AB - In this work, six new mixed-ligand Cu(II), Co(II), Mn(II) complexes with 5-phenyltetrazole (HL) and polypyridine ligands (phen – 1,10-phenanthroline, dmbipy – 2,2′-bi-4-picoline, dmphen – 4,7-dimethyl-1,10-phenanthroline, phendione – 1,10-phenanthroline-5,6-dione), namely, [Cu(dmbipy)(L)2] (1), [Cu2(dmphen)2(L)4] (2), [Cu(phendione)(L)2] (3), [Co3(phen)2(L)6] (4), [Mn3(phen)2(L)4(OAc)2] (5), [Mn(H2O)4(phen)]·phen·2L (6), are reported. Complexes have been characterized by EPR and IR-spectroscopy, elemental, thermogravimetric and powder X-ray diffraction analysis. Molecular structures of [Cu(dmphen)2L]·L·6H2O (2a), [Co3(phen)2(HL)2(L)4(OH)2]·1.9EtOH·1.1DMSO (4a), [Mn3(phen)2(L)4(OAc)2]·H2O (5·H2O) and [Mn(H2O)4(phen)]·phen·2L (6) have been determined by single crystal X–ray diffraction. The UV–vis spectroscopy has been applied to study the behavior of the compounds in solution. All complexes have been screened in vitro for their cytotoxic activity against human cancer cell lines: larynx carcinoma (Hep2), hepatocellular carcinoma (HepG2) and breast adenocarcinoma (MCF-7). Cu(II) complexes exhibit significant dose-dependent cytotoxic effect: [Cu2(dmphen)2(L)4] (2), [Cu(phendione)(L)2] (3) are found to be the most cytotoxic. The antimicrobial activity of complexes and ligands has been investigated against Escherichia coli, Staphylococcus aureus, Penicillium italicum and Colpoda steinii.

KW - 5-Phenyltetrazole

KW - Complexes

KW - Cytotoxicity

KW - Endogenous metals

KW - Polypyridyl ligands

UR - http://www.scopus.com/inward/record.url?scp=85109030237&partnerID=8YFLogxK

U2 - 10.1016/j.poly.2021.115352

DO - 10.1016/j.poly.2021.115352

M3 - Article

AN - SCOPUS:85109030237

VL - 206

JO - Polyhedron

JF - Polyhedron

SN - 0277-5387

M1 - 115352

ER -