Compounds combining aminoadamantane and monoterpene moieties: Cytotoxicity and mutagenic effects

Standard

Compounds combining aminoadamantane and monoterpene moieties: Cytotoxicity and mutagenic effects. / Suslov, Evgeniy V.; Ponomarev, Konstantin Yu; Rogachev, Artem D. и др.

в: Medicinal Chemistry, Том 11, № 7, 01.10.2015, стр. 629-635.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Suslov, EV, Ponomarev, KY, Rogachev, AD , Pokrovsky, MA , Pokrovsky, AG, Pykhtina, MB, Beklemishev, AB, Korchagina, DV, Volcho, KP & Salakhutdinov, NF 2015, 'Compounds combining aminoadamantane and monoterpene moieties: Cytotoxicity and mutagenic effects', Medicinal Chemistry, Том. 11, № 7, стр. 629-635. https://doi.org/10.2174/1573406411666150518110053

APA

Suslov, E. V., Ponomarev, K. Y., Rogachev, A. D., Pokrovsky, M. A., Pokrovsky, A. G., Pykhtina, M. B., Beklemishev, A. B., Korchagina, D. V., Volcho, K. P., & Salakhutdinov, N. F. (2015). Compounds combining aminoadamantane and monoterpene moieties: Cytotoxicity and mutagenic effects. Medicinal Chemistry, 11(7), 629-635. https://doi.org/10.2174/1573406411666150518110053

Vancouver

Suslov EV, Ponomarev KY, Rogachev AD , Pokrovsky MA , Pokrovsky AG, Pykhtina MB и др. Compounds combining aminoadamantane and monoterpene moieties: Cytotoxicity and mutagenic effects. Medicinal Chemistry. 2015 окт. 1;11(7):629-635. doi: 10.2174/1573406411666150518110053

Author

Suslov, Evgeniy V. ; Ponomarev, Konstantin Yu ; Rogachev, Artem D. и др. / Compounds combining aminoadamantane and monoterpene moieties: Cytotoxicity and mutagenic effects. в: Medicinal Chemistry. 2015 ; Том 11, № 7. стр. 629-635.

BibTeX

@article{6315105ca8ee465fb7bbcd581bb70612,

title = "Compounds combining aminoadamantane and monoterpene moieties: Cytotoxicity and mutagenic effects",

abstract = "A series of secondary amines combining monoterpenoid and aminoadamantane moieties have been synthesized. Their cytotoxic activity against human cancer cells CEM-13, MT-4, and U-937 has been studied for the first time. Most of the obtained compounds exhibited a significant cytotoxic activity with the median cytotoxic dose (CTD50) ranging from 6 to 84 μM. The most promising results were obtained for compound 2b which was synthesized from 1-aminoadamantane and (-)-myrtenal and revealed a high activity against all tumor lines used (CTD50= 12/21 μM) along with low toxicity with respect to MDCK cells (CTD50= 1500 μM). The synthesized amines do not exert the genotoxic effect on cells of the biosensor strain based on recombinant E. coli cells bearing the pRAC-gfp plasmid.",

keywords = "Adamantane, Amine, Anticancer activity, Cytotoxicity, Genotoxicity, Monoterpene",

author = "Suslov, {Evgeniy V.} and Ponomarev, {Konstantin Yu} and Rogachev, {Artem D.} and Pokrovsky, {Michail A.} and Pokrovsky, {Andrey G.} and Pykhtina, {Maria B.} and Beklemishev, {Anatoly B.} and Korchagina, {Dina V.} and Volcho, {Konstantin P.} and Salakhutdinov, {Nariman F.}",

year = "2015",

month = oct,

day = "1",

doi = "10.2174/1573406411666150518110053",

language = "English",

volume = "11",

pages = "629--635",

journal = "Medicinal Chemistry",

issn = "1573-4064",

publisher = "BENTHAM SCIENCE PUBL LTD",

number = "7",

}

RIS

TY - JOUR

T1 - Compounds combining aminoadamantane and monoterpene moieties: Cytotoxicity and mutagenic effects

AU - Suslov, Evgeniy V.

AU - Ponomarev, Konstantin Yu

AU - Rogachev, Artem D.

AU - Pokrovsky, Michail A.

AU - Pokrovsky, Andrey G.

AU - Pykhtina, Maria B.

AU - Beklemishev, Anatoly B.

AU - Korchagina, Dina V.

AU - Volcho, Konstantin P.

AU - Salakhutdinov, Nariman F.

PY - 2015/10/1

Y1 - 2015/10/1

N2 - A series of secondary amines combining monoterpenoid and aminoadamantane moieties have been synthesized. Their cytotoxic activity against human cancer cells CEM-13, MT-4, and U-937 has been studied for the first time. Most of the obtained compounds exhibited a significant cytotoxic activity with the median cytotoxic dose (CTD50) ranging from 6 to 84 μM. The most promising results were obtained for compound 2b which was synthesized from 1-aminoadamantane and (-)-myrtenal and revealed a high activity against all tumor lines used (CTD50= 12/21 μM) along with low toxicity with respect to MDCK cells (CTD50= 1500 μM). The synthesized amines do not exert the genotoxic effect on cells of the biosensor strain based on recombinant E. coli cells bearing the pRAC-gfp plasmid.

AB - A series of secondary amines combining monoterpenoid and aminoadamantane moieties have been synthesized. Their cytotoxic activity against human cancer cells CEM-13, MT-4, and U-937 has been studied for the first time. Most of the obtained compounds exhibited a significant cytotoxic activity with the median cytotoxic dose (CTD50) ranging from 6 to 84 μM. The most promising results were obtained for compound 2b which was synthesized from 1-aminoadamantane and (-)-myrtenal and revealed a high activity against all tumor lines used (CTD50= 12/21 μM) along with low toxicity with respect to MDCK cells (CTD50= 1500 μM). The synthesized amines do not exert the genotoxic effect on cells of the biosensor strain based on recombinant E. coli cells bearing the pRAC-gfp plasmid.

KW - Adamantane

KW - Amine

KW - Anticancer activity

KW - Cytotoxicity

KW - Genotoxicity

KW - Monoterpene

UR - http://www.scopus.com/inward/record.url?scp=84945469369&partnerID=8YFLogxK

U2 - 10.2174/1573406411666150518110053

DO - 10.2174/1573406411666150518110053

M3 - Article

C2 - 25981517

AN - SCOPUS:84945469369

VL - 11

SP - 629

EP - 635

JO - Medicinal Chemistry

JF - Medicinal Chemistry

SN - 1573-4064

IS - 7

ER -

ID: 26770709