TY - JOUR

T1 - Color as an important biological variable in zebrafish models

T2 - Implications for translational neurobehavioral research

AU - de Abreu, Murilo S.

AU - Giacomini, Ana C.V.V.

AU - Genario, Rafael

AU - dos Santos, Bruna E.

AU - Marcon, Leticia

AU - Demin, Konstantin A.

AU - Galstyan, David S.

AU - Strekalova, Tatiana

AU - Amstislavskaya, Tamara G.

AU - Kalueff, Allan V.

N1 - Funding Information: ACVVG is supported by the Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul (FAPERGS) research fellowships 17/2551-0001-269-0 . AVK is supported by the Southwest University (Chongqing, China) . He is the President of the International Stress and Behavior Society (ISBS, www.stress-and-behavior.com ) and the chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) that coordinated this collaborative multi-laboratory project. KAD is supported by the President of Russia’s and the SPSU Rector’s Productivity Fellowships for PhD students. The laboratory is supported by the Russian Science Foundation grant 19-05-00053. TGA is supported by the budgetary funding for basic research from the Scientific Research Institute of Neurosciences and Medicine (theme AAAA-A16-116021010228-0 ). Publisher Copyright: © 2020 Elsevier Ltd Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2021/5

Y1 - 2021/5

N2 - Color is an important environmental factor that in multiple ways affects human and animal behavior and physiology. Widely used in neuroscience research, various experimental (animal) models may help improve our understanding of how different colors impact brain and behavioral processes. Complementing laboratory rodents, the zebrafish (Danio rerio) is rapidly emerging as an important novel model species to explore complex neurobehavioral processes. The growing utility of zebrafish in biomedicine makes it timely to consider the role of colors in their behavioral and physiological responses. Here, we summarize mounting evidence implicating colors as a critical variable in zebrafish models and neurobehavioral traits, with a particular relevance to CNS disease modeling, genetic and pharmacological modulation, as well as environmental enrichment and animal welfare. We also discuss the growing value of zebrafish models to study color neurobiology and color-related neurobehavioral phenomics, and outline future directions of research in this field.

AB - Color is an important environmental factor that in multiple ways affects human and animal behavior and physiology. Widely used in neuroscience research, various experimental (animal) models may help improve our understanding of how different colors impact brain and behavioral processes. Complementing laboratory rodents, the zebrafish (Danio rerio) is rapidly emerging as an important novel model species to explore complex neurobehavioral processes. The growing utility of zebrafish in biomedicine makes it timely to consider the role of colors in their behavioral and physiological responses. Here, we summarize mounting evidence implicating colors as a critical variable in zebrafish models and neurobehavioral traits, with a particular relevance to CNS disease modeling, genetic and pharmacological modulation, as well as environmental enrichment and animal welfare. We also discuss the growing value of zebrafish models to study color neurobiology and color-related neurobehavioral phenomics, and outline future directions of research in this field.

KW - Animal model

KW - Cognition

KW - Drugs

KW - Emotional behavior

KW - Social phenotypes

UR - http://www.scopus.com/inward/record.url?scp=85100121404&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/8c49a813-901a-3562-9700-08256352dc22/

U2 - 10.1016/j.neubiorev.2020.12.014

DO - 10.1016/j.neubiorev.2020.12.014

M3 - Review article

C2 - 33359096

AN - SCOPUS:85100121404

VL - 124

SP - 1

EP - 15

JO - Neuroscience and Biobehavioral Reviews

JF - Neuroscience and Biobehavioral Reviews

SN - 0149-7634

ER -