TY - JOUR

T1 - Chromosome synapsis and recombination in male-sterile and female-fertile interspecies hybrids of the dwarf hamsters (Phodopus, cricetidae)

AU - Bikchurina, Tatiana I.

AU - Tishakova, Katerina V.

AU - Kizilova, Elena A.

AU - Romanenko, Svetlana A.

AU - Serdyukova, Natalya A.

AU - Torgasheva, Anna A.

AU - Borodin, Pavel M.

N1 - Publisher Copyright: © 2018 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2018/4/25

Y1 - 2018/4/25

N2 - Hybrid sterility is an important step in the speciation process. Hybrids between dwarf hamsters Phodopus sungorus and P. campbelli provide a good model for studies in cytological and genetic mechanisms of hybrid sterility. Previous studies in hybrids detected multiple abnormalities of spermatogenesis and a high frequency of dissociation between the X and Y chromosomes at the meiotic prophase. In this study, we found that the autosomes of the hybrid males and females underwent paring and recombination as normally as their parental forms did. The male hybrids showed a significantly higher frequency of asynapsis and recombination failure between the heterochromatic arms of the X and Y chromosomes than the males of the parental species. Female hybrids as well as the females of the parental species demonstrated a high incidence of centromere misalignment at the XX bivalent and partial asynapsis of the ends of its heterochromatic arms. In all three karyotypes, recombination was completely suppressed in the heterochromatic arm of the X chromosome, where the pseudoautosomal region is located. We propose that this recombination pattern speeds up divergence of the X- and Y-linked pseudoautosomal regions between the parental species and results in their incompatibility in the male hybrids.

AB - Hybrid sterility is an important step in the speciation process. Hybrids between dwarf hamsters Phodopus sungorus and P. campbelli provide a good model for studies in cytological and genetic mechanisms of hybrid sterility. Previous studies in hybrids detected multiple abnormalities of spermatogenesis and a high frequency of dissociation between the X and Y chromosomes at the meiotic prophase. In this study, we found that the autosomes of the hybrid males and females underwent paring and recombination as normally as their parental forms did. The male hybrids showed a significantly higher frequency of asynapsis and recombination failure between the heterochromatic arms of the X and Y chromosomes than the males of the parental species. Female hybrids as well as the females of the parental species demonstrated a high incidence of centromere misalignment at the XX bivalent and partial asynapsis of the ends of its heterochromatic arms. In all three karyotypes, recombination was completely suppressed in the heterochromatic arm of the X chromosome, where the pseudoautosomal region is located. We propose that this recombination pattern speeds up divergence of the X- and Y-linked pseudoautosomal regions between the parental species and results in their incompatibility in the male hybrids.

KW - Hybrid sterility

KW - MLH1

KW - Pseudoautosomal region

KW - Sex chromosomes

KW - SYCP3

KW - Synaptonemal complex

KW - γH2A.X

KW - X-CHROMOSOME

KW - SUNGORUS

KW - gamma H2A.X

KW - SEX-CHROMOSOMES

KW - SYNAPTONEMAL COMPLEX

KW - sex chromosomes

KW - pseudoautosomal region

KW - synaptonemal complex

KW - hybrid sterility

KW - CRICETULUS-GRISEUS

KW - PSEUDOAUTOSOMAL REGION

KW - GENE

KW - CROSSING-OVER

KW - MICE

KW - MEIOTIC RECOMBINATION

UR - http://www.scopus.com/inward/record.url?scp=85047418060&partnerID=8YFLogxK

U2 - 10.3390/genes9050227

DO - 10.3390/genes9050227

M3 - Article

C2 - 29693587

AN - SCOPUS:85047418060

VL - 9

JO - Genes

JF - Genes

SN - 2073-4425

IS - 5

M1 - 227

ER -