Changes in the Hippocampal Genes Transcriptome in Depression Model Mice upon Intranasal Exposure to M2 Macrophage Secretome Factors

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Changes in the Hippocampal Genes Transcriptome in Depression Model Mice upon Intranasal Exposure to M2 Macrophage Secretome Factors. / Shevela, E. Y.; Markova, E. V.; Knyazheva, M. A. и др.

в: Mathematical Biology and Bioinformatics, Том 15, № 2, 2020, стр. 357-393.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Author

Shevela, E. Y. ; Markova, E. V. ; Knyazheva, M. A. и др. / Changes in the Hippocampal Genes Transcriptome in Depression Model Mice upon Intranasal Exposure to M2 Macrophage Secretome Factors. в: Mathematical Biology and Bioinformatics. 2020 ; Том 15, № 2. стр. 357-393.

BibTeX

@article{72d61623730741bebb80fbc6c5671256,

title = "Changes in the Hippocampal Genes Transcriptome in Depression Model Mice upon Intranasal Exposure to M2 Macrophage Secretome Factors",

abstract = "In the current report, the effect of bioactive compounds of the M2 macrophage secretome on transcription of hippocampal genes in mice with a depression-like condition caused by social stress has been investigated. Surgically resected hippocampus was used for mRNA isolation with following RNA sequencing procedures. Comparative analysis of transcriptomes from the control depressive mice treated with physiological saline solution and mice after intranasal administration of M2 macrophages-conditioned medium revealed that remission of the depressive-like state is associated with a significant up- and downregulation of a number of genes, which were found to participate in restoration/regulation of ATP/Adenosine balance. Among the events associated with positive changes in behavioral pattern of depressive mice, the switch of microglial environment from a pro-inflammatory phenotype to an anti-inflammatory one, and subsequent restoration of compromised cannabinoid and glutamatergic transmitter pathways has been predicted.",

keywords = "ATP, cannabinoid system, glutamate, microglia, neurons, RNAseq",

author = "Shevela, {E. Y.} and Markova, {E. V.} and Knyazheva, {M. A.} and Proskurina, {A. S.} and Efremov, {Y. R.} and Molodtsov, {V. V.} and Seledtsov, {I. A.} and Ostanin, {A. A.} and Bogachev, {S. S.} and Kolchanov, {N. A.} and Chernykh, {E. R.}",

year = "2020",

doi = "10.17537/2020.15.357",

language = "English",

volume = "15",

pages = "357--393",

journal = "Mathematical Biology and Bioinformatics",

issn = "1994-6538",

publisher = "Institute of Mathematical Problems of Biology",

number = "2",

}

RIS

TY - JOUR

T1 - Changes in the Hippocampal Genes Transcriptome in Depression Model Mice upon Intranasal Exposure to M2 Macrophage Secretome Factors

AU - Shevela, E. Y.

AU - Markova, E. V.

AU - Knyazheva, M. A.

AU - Proskurina, A. S.

AU - Efremov, Y. R.

AU - Molodtsov, V. V.

AU - Seledtsov, I. A.

AU - Ostanin, A. A.

AU - Bogachev, S. S.

AU - Kolchanov, N. A.

AU - Chernykh, E. R.

PY - 2020

Y1 - 2020

N2 - In the current report, the effect of bioactive compounds of the M2 macrophage secretome on transcription of hippocampal genes in mice with a depression-like condition caused by social stress has been investigated. Surgically resected hippocampus was used for mRNA isolation with following RNA sequencing procedures. Comparative analysis of transcriptomes from the control depressive mice treated with physiological saline solution and mice after intranasal administration of M2 macrophages-conditioned medium revealed that remission of the depressive-like state is associated with a significant up- and downregulation of a number of genes, which were found to participate in restoration/regulation of ATP/Adenosine balance. Among the events associated with positive changes in behavioral pattern of depressive mice, the switch of microglial environment from a pro-inflammatory phenotype to an anti-inflammatory one, and subsequent restoration of compromised cannabinoid and glutamatergic transmitter pathways has been predicted.

AB - In the current report, the effect of bioactive compounds of the M2 macrophage secretome on transcription of hippocampal genes in mice with a depression-like condition caused by social stress has been investigated. Surgically resected hippocampus was used for mRNA isolation with following RNA sequencing procedures. Comparative analysis of transcriptomes from the control depressive mice treated with physiological saline solution and mice after intranasal administration of M2 macrophages-conditioned medium revealed that remission of the depressive-like state is associated with a significant up- and downregulation of a number of genes, which were found to participate in restoration/regulation of ATP/Adenosine balance. Among the events associated with positive changes in behavioral pattern of depressive mice, the switch of microglial environment from a pro-inflammatory phenotype to an anti-inflammatory one, and subsequent restoration of compromised cannabinoid and glutamatergic transmitter pathways has been predicted.

KW - ATP

KW - cannabinoid system

KW - glutamate

KW - microglia

KW - neurons

KW - RNAseq

UR - http://www.scopus.com/inward/record.url?scp=85099051582&partnerID=8YFLogxK

U2 - 10.17537/2020.15.357

DO - 10.17537/2020.15.357

M3 - Article

AN - SCOPUS:85099051582

VL - 15

SP - 357

EP - 393

JO - Mathematical Biology and Bioinformatics

JF - Mathematical Biology and Bioinformatics

SN - 1994-6538

IS - 2

ER -

ID: 27415216