Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Cellular aspects of gonadal atrophy in Drosophila P-M hybrid dysgenesis. / Dorogova, Natalia V.; Bolobolova, Elena Us; Zakharenko, Lyudmila P.
в: Developmental Biology, Том 424, № 2, 15.04.2017, стр. 105-112.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Cellular aspects of gonadal atrophy in Drosophila P-M hybrid dysgenesis
AU - Dorogova, Natalia V.
AU - Bolobolova, Elena Us
AU - Zakharenko, Lyudmila P.
N1 - Copyright © 2017 Elsevier Inc. All rights reserved.
PY - 2017/4/15
Y1 - 2017/4/15
N2 - Gonadal atrophy is the most typical and dramatic manifestation of intraspecific hybrid dysgenesis syndrome leading to sterility in Drosophila melanogaster dysgenic progeny. The P-M system of hybrid dysgenesis is primarily associated with germ cell degeneration during the early stages of Drosophila embryonic development at elevated temperatures. In the present study, we have defined the phase of germ cell death as beginning at the end of embryogenesis immediately following gonad formation. However, the temperature-dependent screening of germ cell developmental patterns in the dysgenic background showed that early germ cells are susceptible to the hybrid dysgenesis at any Drosophila life-cycle stage, including in the imago. Electron microscopy of germ cells after dysgenesis induction revealed significant changes in subcellular structure, especially mitochondria, prior to cellular breakdown. The mitochondrial pathology can promote the activation of cell death pathways in dysgenic germ cells, which leads to gonadal atrophy.
AB - Gonadal atrophy is the most typical and dramatic manifestation of intraspecific hybrid dysgenesis syndrome leading to sterility in Drosophila melanogaster dysgenic progeny. The P-M system of hybrid dysgenesis is primarily associated with germ cell degeneration during the early stages of Drosophila embryonic development at elevated temperatures. In the present study, we have defined the phase of germ cell death as beginning at the end of embryogenesis immediately following gonad formation. However, the temperature-dependent screening of germ cell developmental patterns in the dysgenic background showed that early germ cells are susceptible to the hybrid dysgenesis at any Drosophila life-cycle stage, including in the imago. Electron microscopy of germ cells after dysgenesis induction revealed significant changes in subcellular structure, especially mitochondria, prior to cellular breakdown. The mitochondrial pathology can promote the activation of cell death pathways in dysgenic germ cells, which leads to gonadal atrophy.
KW - Cell death
KW - Drosophila
KW - Germ cell
KW - Hybrid dysgenesis
KW - Oogenesis
KW - Spermatogenesis
KW - Germ Cells/pathology
KW - Temperature
KW - Mitochondria/metabolism
KW - Male
KW - Atrophy
KW - Drosophila melanogaster/genetics
KW - Phenotype
KW - Animals
KW - Hybridization, Genetic
KW - Gonads/metabolism
KW - Female
KW - MITOCHONDRIA
KW - DEATH
KW - STERILITY
KW - FEMALE
KW - ELEMENTS
KW - MELANOGASTER
UR - http://www.scopus.com/inward/record.url?scp=85015012995&partnerID=8YFLogxK
U2 - 10.1016/j.ydbio.2017.02.020
DO - 10.1016/j.ydbio.2017.02.020
M3 - Article
C2 - 28283407
AN - SCOPUS:85015012995
VL - 424
SP - 105
EP - 112
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 2
ER -
ID: 10040856