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Cell-surface-bound circulating DNA in the blood : Biology and clinical application. / Tamkovich, Svetlana; Laktionov, Pavel.

в: IUBMB Life, Том 71, № 9, 01.09.2019, стр. 1201-1210.

Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование

Harvard

Tamkovich, S & Laktionov, P 2019, 'Cell-surface-bound circulating DNA in the blood: Biology and clinical application', IUBMB Life, Том. 71, № 9, стр. 1201-1210. https://doi.org/10.1002/iub.2070

APA

Tamkovich, S., & Laktionov, P. (2019). Cell-surface-bound circulating DNA in the blood: Biology and clinical application. IUBMB Life, 71(9), 1201-1210. https://doi.org/10.1002/iub.2070

Vancouver

Tamkovich S, Laktionov P. Cell-surface-bound circulating DNA in the blood: Biology and clinical application. IUBMB Life. 2019 сент. 1;71(9):1201-1210. doi: 10.1002/iub.2070

Author

Tamkovich, Svetlana ; Laktionov, Pavel. / Cell-surface-bound circulating DNA in the blood : Biology and clinical application. в: IUBMB Life. 2019 ; Том 71, № 9. стр. 1201-1210.

BibTeX

@article{267e8350bb744ac492e8a8f19a422b1d,
title = "Cell-surface-bound circulating DNA in the blood: Biology and clinical application",
abstract = "Cell-surface-bound extracellular DNA (csbDNA) is present on the outer membrane of blood cells, including both red blood cells and leukocytes. Although less well characterized than cell-free DNA (cfDNA) in plasma and serum, leukocyte and red blood cell csbDNA form a considerable fraction of the blood extracellular nucleic acids pool, with typically at least comparable amount of DNA occurring bound to the outer surface of cells as compared with circulating free DNA in plasma. The cellular origin of csbDNA is not clear; however, as with cfDNA, in patients with cancer a proportion is derived from the tumor, thus making it potentially a useful source of DNA for cancer diagnosis, prognosis, and monitoring.",
keywords = "cancer, cell-surface-bound DNA, circulating DNA, DNase activity, Leukocytes/metabolism, Biomarkers, Tumor/blood, Humans, Erythrocytes/metabolism, Cell-Free Nucleic Acids/blood, Neoplasms/blood, ANTIBODIES, SYSTEMIC-LUPUS-ERYTHEMATOSUS, EXTRACELLULAR DNA, RECEPTOR, HEALTHY, IDENTIFICATION, CANCER, NUCLEIC-ACIDS, PLASMA, BINDING",
author = "Svetlana Tamkovich and Pavel Laktionov",
note = "Publisher Copyright: {\textcopyright} 2019 International Union of Biochemistry and Molecular Biology Copyright: Copyright 2021 Elsevier B.V., All rights reserved.",
year = "2019",
month = sep,
day = "1",
doi = "10.1002/iub.2070",
language = "English",
volume = "71",
pages = "1201--1210",
journal = "IUBMB Life",
issn = "1521-6543",
publisher = "Wiley-Blackwell",
number = "9",

}

RIS

TY - JOUR

T1 - Cell-surface-bound circulating DNA in the blood

T2 - Biology and clinical application

AU - Tamkovich, Svetlana

AU - Laktionov, Pavel

N1 - Publisher Copyright: © 2019 International Union of Biochemistry and Molecular Biology Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Cell-surface-bound extracellular DNA (csbDNA) is present on the outer membrane of blood cells, including both red blood cells and leukocytes. Although less well characterized than cell-free DNA (cfDNA) in plasma and serum, leukocyte and red blood cell csbDNA form a considerable fraction of the blood extracellular nucleic acids pool, with typically at least comparable amount of DNA occurring bound to the outer surface of cells as compared with circulating free DNA in plasma. The cellular origin of csbDNA is not clear; however, as with cfDNA, in patients with cancer a proportion is derived from the tumor, thus making it potentially a useful source of DNA for cancer diagnosis, prognosis, and monitoring.

AB - Cell-surface-bound extracellular DNA (csbDNA) is present on the outer membrane of blood cells, including both red blood cells and leukocytes. Although less well characterized than cell-free DNA (cfDNA) in plasma and serum, leukocyte and red blood cell csbDNA form a considerable fraction of the blood extracellular nucleic acids pool, with typically at least comparable amount of DNA occurring bound to the outer surface of cells as compared with circulating free DNA in plasma. The cellular origin of csbDNA is not clear; however, as with cfDNA, in patients with cancer a proportion is derived from the tumor, thus making it potentially a useful source of DNA for cancer diagnosis, prognosis, and monitoring.

KW - cancer

KW - cell-surface-bound DNA

KW - circulating DNA

KW - DNase activity

KW - Leukocytes/metabolism

KW - Biomarkers, Tumor/blood

KW - Humans

KW - Erythrocytes/metabolism

KW - Cell-Free Nucleic Acids/blood

KW - Neoplasms/blood

KW - ANTIBODIES

KW - SYSTEMIC-LUPUS-ERYTHEMATOSUS

KW - EXTRACELLULAR DNA

KW - RECEPTOR

KW - HEALTHY

KW - IDENTIFICATION

KW - CANCER

KW - NUCLEIC-ACIDS

KW - PLASMA

KW - BINDING

UR - http://www.scopus.com/inward/record.url?scp=85065995089&partnerID=8YFLogxK

U2 - 10.1002/iub.2070

DO - 10.1002/iub.2070

M3 - Review article

C2 - 31091350

AN - SCOPUS:85065995089

VL - 71

SP - 1201

EP - 1210

JO - IUBMB Life

JF - IUBMB Life

SN - 1521-6543

IS - 9

ER -

ID: 23570127