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Cell Volume Regulation of Endothelial Cells Is Impaired in Keratoconus Cornea. / Kuseina, I. M.; Katkova, L. E.; Baturina, G. S. и др.

в: Биологические мембраны, Том 41, № 3, 25.09.2024, стр. 211-218.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Kuseina, IM, Katkova, LE, Baturina, GS, Palchikova, IG, Iskakov, IA & Solenov, EI 2024, 'Cell Volume Regulation of Endothelial Cells Is Impaired in Keratoconus Cornea', Биологические мембраны, Том. 41, № 3, стр. 211-218. https://doi.org/10.31857/S0233475524030042

APA

Kuseina, I. M., Katkova, L. E., Baturina, G. S., Palchikova, I. G., Iskakov, I. A., & Solenov, E. I. (2024). Cell Volume Regulation of Endothelial Cells Is Impaired in Keratoconus Cornea. Биологические мембраны, 41(3), 211-218. https://doi.org/10.31857/S0233475524030042

Vancouver

Kuseina IM, Katkova LE, Baturina GS, Palchikova IG, Iskakov IA, Solenov EI. Cell Volume Regulation of Endothelial Cells Is Impaired in Keratoconus Cornea. Биологические мембраны. 2024 сент. 25;41(3):211-218. doi: 10.31857/S0233475524030042

Author

Kuseina, I. M. ; Katkova, L. E. ; Baturina, G. S. и др. / Cell Volume Regulation of Endothelial Cells Is Impaired in Keratoconus Cornea. в: Биологические мембраны. 2024 ; Том 41, № 3. стр. 211-218.

BibTeX

@article{abf9a67a4e7044f1b162152c87ed98d0,
title = "Cell Volume Regulation of Endothelial Cells Is Impaired in Keratoconus Cornea",
abstract = "In this work the permeability to water and urea of plasma membranes of endothelial cells of normal corneas and corneas with keratoconus was investigated. The endothelial cells were obtained from surgery material. Measurements of osmotic aqueous permeability (Pf) of endothelial cells in normal and in keratoconus did not reveal significant differences of this parameter in the two studied groups. The control cells and the cells from keratoconus cornea have similar osmotic water permeability (control cells, P-f = 0.53 +/- 0.045 cm/s; keratoconus cells, P-f = 0.63 +/- 0.041 cm/s; n = 25; p > 0.05). Neither coefficient of urea permeability differed significantly in these groups (control, P-u = 0.049 +/- 0.003 cm/s; keratoconus, P-u = 0.056 +/- 0.003 cm/s; n = 25; p > 0.05). Analysis of cell volume dynamics based on exponential approximation showed a more pronounced decrease of the cell volume of endothelial cells from keratoconus cornea in hypertonic medium in comparison with the cells from normal cornea. The increase of cell volume caused by isotonic entering of urea into the cells in hypertonic medium also was more pronounced in these cells in comparison with the normal ones. We conclude that there are significant changes in cell volume regulating mechanism in keratoconus cornea endothelial cells.",
author = "Kuseina, {I. M.} and Katkova, {L. E.} and Baturina, {G. S.} and Palchikova, {I. G.} and Iskakov, {I. A.} and Solenov, {E. i.}",
note = "Работа выполнена при поддержке бюджетного проекта FWNR-2022-0019.",
year = "2024",
month = sep,
day = "25",
doi = "10.31857/S0233475524030042",
language = "English",
volume = "41",
pages = "211--218",
journal = "Биологические мембраны",
issn = "0233-4755",
publisher = "Научный и издательский центр {"}Наука РАН{"}",
number = "3",

}

RIS

TY - JOUR

T1 - Cell Volume Regulation of Endothelial Cells Is Impaired in Keratoconus Cornea

AU - Kuseina, I. M.

AU - Katkova, L. E.

AU - Baturina, G. S.

AU - Palchikova, I. G.

AU - Iskakov, I. A.

AU - Solenov, E. i.

N1 - Работа выполнена при поддержке бюджетного проекта FWNR-2022-0019.

PY - 2024/9/25

Y1 - 2024/9/25

N2 - In this work the permeability to water and urea of plasma membranes of endothelial cells of normal corneas and corneas with keratoconus was investigated. The endothelial cells were obtained from surgery material. Measurements of osmotic aqueous permeability (Pf) of endothelial cells in normal and in keratoconus did not reveal significant differences of this parameter in the two studied groups. The control cells and the cells from keratoconus cornea have similar osmotic water permeability (control cells, P-f = 0.53 +/- 0.045 cm/s; keratoconus cells, P-f = 0.63 +/- 0.041 cm/s; n = 25; p > 0.05). Neither coefficient of urea permeability differed significantly in these groups (control, P-u = 0.049 +/- 0.003 cm/s; keratoconus, P-u = 0.056 +/- 0.003 cm/s; n = 25; p > 0.05). Analysis of cell volume dynamics based on exponential approximation showed a more pronounced decrease of the cell volume of endothelial cells from keratoconus cornea in hypertonic medium in comparison with the cells from normal cornea. The increase of cell volume caused by isotonic entering of urea into the cells in hypertonic medium also was more pronounced in these cells in comparison with the normal ones. We conclude that there are significant changes in cell volume regulating mechanism in keratoconus cornea endothelial cells.

AB - In this work the permeability to water and urea of plasma membranes of endothelial cells of normal corneas and corneas with keratoconus was investigated. The endothelial cells were obtained from surgery material. Measurements of osmotic aqueous permeability (Pf) of endothelial cells in normal and in keratoconus did not reveal significant differences of this parameter in the two studied groups. The control cells and the cells from keratoconus cornea have similar osmotic water permeability (control cells, P-f = 0.53 +/- 0.045 cm/s; keratoconus cells, P-f = 0.63 +/- 0.041 cm/s; n = 25; p > 0.05). Neither coefficient of urea permeability differed significantly in these groups (control, P-u = 0.049 +/- 0.003 cm/s; keratoconus, P-u = 0.056 +/- 0.003 cm/s; n = 25; p > 0.05). Analysis of cell volume dynamics based on exponential approximation showed a more pronounced decrease of the cell volume of endothelial cells from keratoconus cornea in hypertonic medium in comparison with the cells from normal cornea. The increase of cell volume caused by isotonic entering of urea into the cells in hypertonic medium also was more pronounced in these cells in comparison with the normal ones. We conclude that there are significant changes in cell volume regulating mechanism in keratoconus cornea endothelial cells.

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85204494901&origin=inward&txGid=c9f259722641b0cf3b4bd9d51c37475d

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001314765300004

U2 - 10.31857/S0233475524030042

DO - 10.31857/S0233475524030042

M3 - Article

VL - 41

SP - 211

EP - 218

JO - Биологические мембраны

JF - Биологические мембраны

SN - 0233-4755

IS - 3

ER -

ID: 61228239