TY - JOUR

T1 - Breath indeed carries significant information about a disease

T2 - Potential biomarkers of cerebral palsy

AU - Maiti, Kiran Sankar

AU - Roy, Susmita

AU - Lampe, Renée

AU - Apolonski, Alexander

N1 - Publisher Copyright: © 2020 The Authors. Journal of Biophotonics published by WILEY-VCH GmbH

PY - 2020/11/1

Y1 - 2020/11/1

N2 - Objective and reliable noninvasive medical diagnostics of a large variety of diseases is still a dream. As a step in the direction of realization, a spectroscopic breath study of cerebral palsy (CP) was performed. Principal component analysis revealed data clustering for a healthy group and CP individuals was observed, with a P-value below 10−5. Learning algorithms resulted in 91% accuracy in distinguishing the groups. With the help of manual analysis of absorption spectral features of breath samples, two volatile organic compounds were identified that demonstrate significant deviations in the groups. These represent two esters of propionic acid (PPAE). A transportation scheme was hypothesized that links the gut where propionic acid (PPA) and PPAE are produced, the brain of CP patients, through which PPA and PPAE transmit, and the lungs where PPAE releases. The results show a possibility to detect one more brain-related disorder via breath, in this case CP.

AB - Objective and reliable noninvasive medical diagnostics of a large variety of diseases is still a dream. As a step in the direction of realization, a spectroscopic breath study of cerebral palsy (CP) was performed. Principal component analysis revealed data clustering for a healthy group and CP individuals was observed, with a P-value below 10−5. Learning algorithms resulted in 91% accuracy in distinguishing the groups. With the help of manual analysis of absorption spectral features of breath samples, two volatile organic compounds were identified that demonstrate significant deviations in the groups. These represent two esters of propionic acid (PPAE). A transportation scheme was hypothesized that links the gut where propionic acid (PPA) and PPAE are produced, the brain of CP patients, through which PPA and PPAE transmit, and the lungs where PPAE releases. The results show a possibility to detect one more brain-related disorder via breath, in this case CP.

KW - breath

KW - cerebral palsy

KW - mid-infrared spectroscopy

KW - noninvasive medical diagnostics

KW - propionic acid esters

KW - DIAGNOSIS

KW - SPECTROSCOPY

KW - FINGERPRINT

KW - EXHALED BREATH

UR - http://www.scopus.com/inward/record.url?scp=85089453964&partnerID=8YFLogxK

U2 - 10.1002/jbio.202000125

DO - 10.1002/jbio.202000125

M3 - Article

C2 - 32526081

AN - SCOPUS:85089453964

VL - 13

SP - e202000125

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 11

M1 - e202000125

ER -