TY - JOUR

T1 - Brain but not serum BDNF levels are associated with structural alterations in the hippocampal regions in patients with drug-resistant mesial temporal lobe epilepsy

AU - Filimonova, Elena A

AU - Pashkov, Anton A

AU - Moysak, Galina I

AU - Tropynina, Anastasia Y

AU - Zhanaeva, Svetlana Y

AU - Shvaikovskaya, Anna A

AU - Akopyan, Anna A

AU - Danilenko, Konstantin V

AU - Aftanas, Lyubomir I

AU - Tikhonova, Maria A

AU - Rzaev, Jamil A

N1 - Funding: This study was funded by the Russian Science Foundation (grant no. 22-25-00588). Copyright © 2023 Filimonova, Pashkov, Moysak, Tropynina, Zhanaeva, Shvaikovskaya, Akopyan, Danilenko, Aftanas, Tikhonova and Rzaev.

PY - 2023

Y1 - 2023

N2 - Mesial temporal lobe epilepsy is the most common type of focal epilepsy, imposing a significant burden on the health care system worldwide. Approximately one-third of patients with this disease who do not adequately respond to pharmacotherapy are considered drug-resistant subjects. Despite having some clues of how such epileptic activity and resistance to therapy emerge, coming mainly from preclinical models, we still witness a scarcity of human data. To narrow this gap, in this study, we aimed to estimate the relationship between hippocampal and serum levels of brain-derived neurotrophic factor (BDNF), one of the main and most widely studied neurotrophins, and hippocampal subfield volumes in patients with drug-resistant mesial temporal epilepsy undergoing neurosurgical treatment. We found that hippocampal (but not serum) BDNF levels were negatively correlated with the contralateral volumes of the CA1 and CA4 subfields, presubiculum, subiculum, dentate gyrus, and molecular layer of the hippocampus. Taken together, these findings are generally in accordance with existing data, arguing for a proepileptic nature of BDNF effects in the hippocampus and related brain structures.

AB - Mesial temporal lobe epilepsy is the most common type of focal epilepsy, imposing a significant burden on the health care system worldwide. Approximately one-third of patients with this disease who do not adequately respond to pharmacotherapy are considered drug-resistant subjects. Despite having some clues of how such epileptic activity and resistance to therapy emerge, coming mainly from preclinical models, we still witness a scarcity of human data. To narrow this gap, in this study, we aimed to estimate the relationship between hippocampal and serum levels of brain-derived neurotrophic factor (BDNF), one of the main and most widely studied neurotrophins, and hippocampal subfield volumes in patients with drug-resistant mesial temporal epilepsy undergoing neurosurgical treatment. We found that hippocampal (but not serum) BDNF levels were negatively correlated with the contralateral volumes of the CA1 and CA4 subfields, presubiculum, subiculum, dentate gyrus, and molecular layer of the hippocampus. Taken together, these findings are generally in accordance with existing data, arguing for a proepileptic nature of BDNF effects in the hippocampus and related brain structures.

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85166627545&origin=inward&txGid=eb5d47cc29735650d2c7f334c2c5830f

U2 - 10.3389/fnins.2023.1217702

DO - 10.3389/fnins.2023.1217702

M3 - Article

C2 - 37539386

VL - 17

JO - Frontiers in Neuroscience

JF - Frontiers in Neuroscience

SN - 1662-4548

M1 - 1217702

ER -