TY - GEN

T1 - Body composition in woman with rheumatoid arthritis

AU - Omelchenko, Vitaliy

AU - Kurochkina, Yuliya

AU - Akimova, Anna

AU - Letyagina, Elena

AU - Shaidurova, Margarita

AU - Korolev, Maxim

PY - 2022

Y1 - 2022

N2 - Rheumatoid arthritis is a common rheumatic disease, characterized by erosive joint damage and destruction of internal organs. Chronic inflammation, malnutrition, physical disability, comorbid conditions, the use of steroids and biologics may also affect the body composition in patients with RA and lead to rheumatoid cachexia.Aim of the study: The aim of this study was to evaluate body composition in patients with rheumatoid arthritis.Materials and methods: Forty five women over 18 years of age with RA verified based on the 2010 ACR/EULAR criteria were included. The median age of patients was 54 years [45; 61] with a disease duration of 11 years [7; 20]. Patients with moderate disease activity prevailed (DAS28 4.40 [4.07; 5.03]).Results: The median AMI was 6.4 [5.5; 7.3]. Sarcopenia, assessed based on AMI, was detected in 16 (35.6%) patients. Patients with sarcopenia were younger (p = 0.044). They had a predominantly normal BMI (p = 0.001) and had a decrease in the percentage of androgynous adipose tissue (p=0,007). After excluding the total body mass, an inverse relationship was revealed between the AMM and CRP (rs=-0,524; p=0.009), By calculating partial correlations, excluding the total body mass, an inverse relationship was revealed between the AMM and CRP (rs=-0,524; p=0.009), TG (rs=-0.523; p=0.009) and LDL (rs=-0.421; p=0.01). Sarcopenia was more common in patients receiving sulfasalazine (p=0.29) and prednisolone (p=0.42).Conclusions: Sarcopenia was more common revealed in young patients with rheumatoid arthritis with normal body weight. SP was associated with taken of prednisolone and sulfasalazine.

AB - Rheumatoid arthritis is a common rheumatic disease, characterized by erosive joint damage and destruction of internal organs. Chronic inflammation, malnutrition, physical disability, comorbid conditions, the use of steroids and biologics may also affect the body composition in patients with RA and lead to rheumatoid cachexia.Aim of the study: The aim of this study was to evaluate body composition in patients with rheumatoid arthritis.Materials and methods: Forty five women over 18 years of age with RA verified based on the 2010 ACR/EULAR criteria were included. The median age of patients was 54 years [45; 61] with a disease duration of 11 years [7; 20]. Patients with moderate disease activity prevailed (DAS28 4.40 [4.07; 5.03]).Results: The median AMI was 6.4 [5.5; 7.3]. Sarcopenia, assessed based on AMI, was detected in 16 (35.6%) patients. Patients with sarcopenia were younger (p = 0.044). They had a predominantly normal BMI (p = 0.001) and had a decrease in the percentage of androgynous adipose tissue (p=0,007). After excluding the total body mass, an inverse relationship was revealed between the AMM and CRP (rs=-0,524; p=0.009), By calculating partial correlations, excluding the total body mass, an inverse relationship was revealed between the AMM and CRP (rs=-0,524; p=0.009), TG (rs=-0.523; p=0.009) and LDL (rs=-0.421; p=0.01). Sarcopenia was more common in patients receiving sulfasalazine (p=0.29) and prednisolone (p=0.42).Conclusions: Sarcopenia was more common revealed in young patients with rheumatoid arthritis with normal body weight. SP was associated with taken of prednisolone and sulfasalazine.

UR - https://www.scopus.com/inward/record.url?eid=2-s2.0-85147507175&partnerID=40&md5=024f926483446e08f7e9696768b32d4b

UR - https://www.mendeley.com/catalogue/e12b472f-c76d-3d06-808c-fbdbc290fc4c/

U2 - 10.1109/sibircon56155.2022.10016974

DO - 10.1109/sibircon56155.2022.10016974

M3 - Conference contribution

SN - 9781665464802

SP - 280

EP - 283

BT - 2022 IEEE International Multi-Conference on Engineering, Computer and Information Sciences (SIBIRCON)

PB - Institute of Electrical and Electronics Engineers (IEEE)

T2 - 2022 IEEE International Multi-Conference on Engineering, Computer and Information Sciences, SIBIRCON 2022

Y2 - 11 November 2022 through 13 November 2022

ER -