Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › статья в сборнике материалов конференции › научная › Рецензирование
BNCT for veterinary medicine. / Каныгин, Владимир Владимирович; Кичигин, Александр Иванович; Петрова, Е. и др.
19th International Congress on Neutron Capture Therapy Granada, Spain, September 27th - October 1st, 2021. Book of Abstacts. Вена : International Atomic Energy Agency, 2021. стр. 159 О62.Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › статья в сборнике материалов конференции › научная › Рецензирование
}
TY - GEN
T1 - BNCT for veterinary medicine
AU - Каныгин, Владимир Владимирович
AU - Кичигин, Александр Иванович
AU - Петрова, Е.
AU - Цыганкова, Альфия Рафаэльевна
AU - Аникин, Михаил
AU - Касатов, Дмитрий Александрович
AU - Щудло, Иван Михайлович
AU - Макаров, Александр Николаевич
AU - Сычева, Татьяна Викторовна
AU - Таскаев, Сергей Юрьевич
N1 - Conference code: 19
PY - 2021
Y1 - 2021
N2 - We provided clinical veterinary BNCT studies in cats and dogs with spontaneous malignant tumors on accelerator based epithermal neutron source at Budker Institute of Nuclear Physics in Novosibirsk, Russia and IRT-T research reactor at National Research Tomsk Polytechnic University in Tomsk, Russia. These animals were selected for this method of therapy due to the impossibility of performing surgical treatment and other methods of therapy. BSH (Katchem, Czech Republic) was used as boron compound at a dose of 100 mg / kg, intravenous infusion lasting 1 hour. Before and after irradiation, blood samples were taken from the animal to study the boron concentration with an ICPE-9820 atomic emission spectrometer (Shimadzu, Japan). A preliminary calculation of the dose in the tumor and skin was carried out using the tomography data by the Monte Carlo method. In all cases, we observed partial tumor response, clinical benefit, and an increase in estimated survival time when recruited with excellent quality of life. Treatment-related toxicity was mild and reversible. These studies contribute to the preparation for clinical trials of BNCT for the treatment malignant tumors in Russia and suggest a potential role for BNCT in veterinary medicine.
AB - We provided clinical veterinary BNCT studies in cats and dogs with spontaneous malignant tumors on accelerator based epithermal neutron source at Budker Institute of Nuclear Physics in Novosibirsk, Russia and IRT-T research reactor at National Research Tomsk Polytechnic University in Tomsk, Russia. These animals were selected for this method of therapy due to the impossibility of performing surgical treatment and other methods of therapy. BSH (Katchem, Czech Republic) was used as boron compound at a dose of 100 mg / kg, intravenous infusion lasting 1 hour. Before and after irradiation, blood samples were taken from the animal to study the boron concentration with an ICPE-9820 atomic emission spectrometer (Shimadzu, Japan). A preliminary calculation of the dose in the tumor and skin was carried out using the tomography data by the Monte Carlo method. In all cases, we observed partial tumor response, clinical benefit, and an increase in estimated survival time when recruited with excellent quality of life. Treatment-related toxicity was mild and reversible. These studies contribute to the preparation for clinical trials of BNCT for the treatment malignant tumors in Russia and suggest a potential role for BNCT in veterinary medicine.
UR - https://elibrary.ru/item.asp?id=47962074&pff=1
M3 - Conference contribution
SP - 159
BT - 19th International Congress on Neutron Capture Therapy Granada, Spain, September 27th - October 1st, 2021. Book of Abstacts
PB - International Atomic Energy Agency
CY - Вена
T2 - 19th International Congress on Neutron Capture Therapy
Y2 - 27 September 2021 through 1 October 2021
ER -
ID: 34969683