TY - JOUR

T1 - Bioactive mixed-ligand zinc(II) complexes with 1H-tetrazole-5-acetic acid and oligopyridine derivatives

AU - Ermakova, Ekaterina A.

AU - Golubeva, Julia A.

AU - Smirnova, Ksenia S.

AU - Klyushova, Lyubov S.

AU - Eltsov, Ilia V.

AU - Zubenko, Alexander A.

AU - Fetisov, Leonid N.

AU - Svyatogorova, Alexandra E.

AU - Lider, Elizaveta V.

N1 - Funding Information: This work was supported by the Russian Science Foundation (Project № 20-73-10207). The research (Nikolaev Institute of Inorganic Chemistry SB RAS) was supported by the Ministry of Science and Higher Education of the Russian Federation, N121031700321-3. The authors thank Anna P. Zubareva and Natalia N. Komardina for the elemental analysis, Anastasia O. Matveeva for the X-ray phase analysis data, Taisiya S. Sukhikh and Vladislav Yu. Komarov for providing the data collected in the XRD Facility of NIIC SB RAS. The work was performed using the equipment of the Center for Collective Use “Proteomic Analysis”, supported by funding from the Ministry of Science and Higher Education of the Russian Federation (agreement No. 075-15-2021-691). Funding Information: The authors thank Anna P. Zubareva and Natalia N. Komardina for the elemental analysis, Anastasia O. Matveeva for the X-ray phase analysis data, Taisiya S. Sukhikh and Vladislav Yu. Komarov for providing the data collected in the XRD Facility of NIIC SB RAS. The work was performed using the equipment of the Center for Collective Use “Proteomic Analysis”, supported by funding from the Ministry of Science and Higher Education of the Russian Federation (agreement No. 075-15-2021-691). Funding Information: This work was supported by the Russian Science Foundation (Project № 20-73-10207). The research (Nikolaev Institute of Inorganic Chemistry SB RAS) was supported by the Ministry of Science and Higher Education of the Russian Federation , N121031700321-3 . Publisher Copyright: © 2022 Elsevier Ltd

PY - 2023/1/15

Y1 - 2023/1/15

N2 - 1H-tetrazole-5-acetic acid is bifunctional ligand that was employed for the synthesis of zinc(II) complexes in the presence of secondary ligands such as oligopyridines (dmphen – 4,7-dimethyl-1,10-phenanthroline, phendione – 1,10-phenanthroline-5,6-dione, phen – 1,10-phenanthroline, dmbipy – 2,2′-bi-4-picoline, bipy – 2,2′-bipyridine). Five new mixed-ligand zinc(II) complexes [Zn(dmphen)L]·H2O (1), [Zn(phendione)(H2O)L]·2H2O (2), [Zn(phen)L]·0,5H2O (3), {[Zn(dmbipy)L]·H2O}n (4) and [Zn(bipy)L]·H2O (5) have been synthesized and characterized by elemental analysis, IR spectroscopy and powder X-ray diffraction. All complexes have shown to possess thermal stability up to 250°C by thermogravimetric analysis, except for complexes 2 and 5, which have been stable up to 200° C. Crystal structures of polymeric complexes {[Zn(dmphen)(H2O)2L]·2H2O}n (1a) and 4 have been determined by single-crystal X-ray diffraction analysis. The effect of the compounds on viability of HepG-2, MCF–7 and MRC-5 cell lines has been investigated. Complex 2 was found to be the most cytotoxic with IC50 values of 6.4 ± 0.9 µM for HepG-2 cells and 2.6 ± 1.1 µM for MCF-7 cells. The antimicrobial activity of the complexes and ligands has been investigated against E. coli, S. aureus, P. italicum and C. steinii.

AB - 1H-tetrazole-5-acetic acid is bifunctional ligand that was employed for the synthesis of zinc(II) complexes in the presence of secondary ligands such as oligopyridines (dmphen – 4,7-dimethyl-1,10-phenanthroline, phendione – 1,10-phenanthroline-5,6-dione, phen – 1,10-phenanthroline, dmbipy – 2,2′-bi-4-picoline, bipy – 2,2′-bipyridine). Five new mixed-ligand zinc(II) complexes [Zn(dmphen)L]·H2O (1), [Zn(phendione)(H2O)L]·2H2O (2), [Zn(phen)L]·0,5H2O (3), {[Zn(dmbipy)L]·H2O}n (4) and [Zn(bipy)L]·H2O (5) have been synthesized and characterized by elemental analysis, IR spectroscopy and powder X-ray diffraction. All complexes have shown to possess thermal stability up to 250°C by thermogravimetric analysis, except for complexes 2 and 5, which have been stable up to 200° C. Crystal structures of polymeric complexes {[Zn(dmphen)(H2O)2L]·2H2O}n (1a) and 4 have been determined by single-crystal X-ray diffraction analysis. The effect of the compounds on viability of HepG-2, MCF–7 and MRC-5 cell lines has been investigated. Complex 2 was found to be the most cytotoxic with IC50 values of 6.4 ± 0.9 µM for HepG-2 cells and 2.6 ± 1.1 µM for MCF-7 cells. The antimicrobial activity of the complexes and ligands has been investigated against E. coli, S. aureus, P. italicum and C. steinii.

KW - Crystal structure

KW - Cytotoxicity

KW - Oligopyridine

KW - Tetrazole

KW - Zinc(II) complexes

UR - http://www.scopus.com/inward/record.url?scp=85142544949&partnerID=8YFLogxK

U2 - 10.1016/j.poly.2022.116213

DO - 10.1016/j.poly.2022.116213

M3 - Article

AN - SCOPUS:85142544949

VL - 230

JO - Polyhedron

JF - Polyhedron

SN - 0277-5387

M1 - 116213

ER -