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Bacillus pumilus Ribonuclease Inhibits Migration of Human Duodenum Adenocarcinoma HuTu 80 Cells. / Zelenikhin, P.; Mohamed, I. S. Ead; Nadyrova, A. и др.

в: Molecular Biology, Том 54, № 1, 01.2020, стр. 128-133.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Zelenikhin, P, Mohamed, ISE, Nadyrova, A, Sirotkina, AA, Ulyanova, VV, Mironova, NL, Mitkevieh, VA, Makarov, AA, Zenkova, MA & Ilinskaya, ON 2020, 'Bacillus pumilus Ribonuclease Inhibits Migration of Human Duodenum Adenocarcinoma HuTu 80 Cells', Molecular Biology, Том. 54, № 1, стр. 128-133. https://doi.org/10.1134/S0026893320010173

APA

Zelenikhin, P., Mohamed, I. S. E., Nadyrova, A., Sirotkina, A. A., Ulyanova, V. V., Mironova, N. L., Mitkevieh, V. A., Makarov, A. A., Zenkova, M. A., & Ilinskaya, O. N. (2020). Bacillus pumilus Ribonuclease Inhibits Migration of Human Duodenum Adenocarcinoma HuTu 80 Cells. Molecular Biology, 54(1), 128-133. https://doi.org/10.1134/S0026893320010173

Vancouver

Zelenikhin P, Mohamed ISE, Nadyrova A, Sirotkina AA, Ulyanova VV, Mironova NL и др. Bacillus pumilus Ribonuclease Inhibits Migration of Human Duodenum Adenocarcinoma HuTu 80 Cells. Molecular Biology. 2020 янв.;54(1):128-133. doi: 10.1134/S0026893320010173

Author

Zelenikhin, P. ; Mohamed, I. S. Ead ; Nadyrova, A. и др. / Bacillus pumilus Ribonuclease Inhibits Migration of Human Duodenum Adenocarcinoma HuTu 80 Cells. в: Molecular Biology. 2020 ; Том 54, № 1. стр. 128-133.

BibTeX

@article{266ef2d6b25342c5b272e1edc0a10d0f,
title = "Bacillus pumilus Ribonuclease Inhibits Migration of Human Duodenum Adenocarcinoma HuTu 80 Cells",
abstract = "Migration of cancer cells from the primary tumor site to nearby tissues is the starting point of the metastatic process. The invasive properties of cells are especially important for carcinomas, since tumor cells need to overcome the basement membrane and go beyond its boundaries to the underlying tissues. Substances that reduce the invasive ability of malignant cells are promising as antimetastatic agents. In the present work, the possibility of inhibiting the ability of different cancer cell lines to migrate under the influence of the Bacillus pumilus ribonuclease (binase) was analyzed using the scratch-wound assay. It was established that binase at non-toxic concentrations (10 mu g/mL) reliably suppressed the migratory ability of HuTu 80 human duodenum adenocarcinoma cells incubated with RNase for 48-72 h. The antimetastatic potential of binase is confirmed by molecular modeling data demonstrating the ability of binase to inhibit cellular metalloproteinases that determine the migration of tumor cells.",
keywords = "ribonuclease, binase, carcinoma, melanoma, invasion, RAS oncogene, ADAM metalloproteinases, BINASE, METALLOPROTEINASES, PROLIFERATION, TARGETS, CANCER, TUMOR",
author = "P. Zelenikhin and Mohamed, {I. S. Ead} and A. Nadyrova and Sirotkina, {A. A.} and Ulyanova, {V. V.} and Mironova, {N. L.} and Mitkevieh, {V. A.} and Makarov, {A. A.} and Zenkova, {M. A.} and Ilinskaya, {O. N.}",
note = "Зеленихин П.В., Мохамед И.С. Еад, Надырова А.И., Сироткина А.А., Ульянова В.В., Миронова Н.Л., Митькевич В.А., Макаров А.А., Зенкова М.А., Ильинская О.Н. Рибонуклеаза Bacillus pumilus ингибирует миграцию клеток аденокарциномы двенадцатиперстной кишки человека HuTu 80 // Молекулярная биология. – 2020. – Т. 54. – № 1. – С. 146-152.",
year = "2020",
month = jan,
doi = "10.1134/S0026893320010173",
language = "English",
volume = "54",
pages = "128--133",
journal = "Molecular Biology",
issn = "0026-8933",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "1",

}

RIS

TY - JOUR

T1 - Bacillus pumilus Ribonuclease Inhibits Migration of Human Duodenum Adenocarcinoma HuTu 80 Cells

AU - Zelenikhin, P.

AU - Mohamed, I. S. Ead

AU - Nadyrova, A.

AU - Sirotkina, A. A.

AU - Ulyanova, V. V.

AU - Mironova, N. L.

AU - Mitkevieh, V. A.

AU - Makarov, A. A.

AU - Zenkova, M. A.

AU - Ilinskaya, O. N.

N1 - Зеленихин П.В., Мохамед И.С. Еад, Надырова А.И., Сироткина А.А., Ульянова В.В., Миронова Н.Л., Митькевич В.А., Макаров А.А., Зенкова М.А., Ильинская О.Н. Рибонуклеаза Bacillus pumilus ингибирует миграцию клеток аденокарциномы двенадцатиперстной кишки человека HuTu 80 // Молекулярная биология. – 2020. – Т. 54. – № 1. – С. 146-152.

PY - 2020/1

Y1 - 2020/1

N2 - Migration of cancer cells from the primary tumor site to nearby tissues is the starting point of the metastatic process. The invasive properties of cells are especially important for carcinomas, since tumor cells need to overcome the basement membrane and go beyond its boundaries to the underlying tissues. Substances that reduce the invasive ability of malignant cells are promising as antimetastatic agents. In the present work, the possibility of inhibiting the ability of different cancer cell lines to migrate under the influence of the Bacillus pumilus ribonuclease (binase) was analyzed using the scratch-wound assay. It was established that binase at non-toxic concentrations (10 mu g/mL) reliably suppressed the migratory ability of HuTu 80 human duodenum adenocarcinoma cells incubated with RNase for 48-72 h. The antimetastatic potential of binase is confirmed by molecular modeling data demonstrating the ability of binase to inhibit cellular metalloproteinases that determine the migration of tumor cells.

AB - Migration of cancer cells from the primary tumor site to nearby tissues is the starting point of the metastatic process. The invasive properties of cells are especially important for carcinomas, since tumor cells need to overcome the basement membrane and go beyond its boundaries to the underlying tissues. Substances that reduce the invasive ability of malignant cells are promising as antimetastatic agents. In the present work, the possibility of inhibiting the ability of different cancer cell lines to migrate under the influence of the Bacillus pumilus ribonuclease (binase) was analyzed using the scratch-wound assay. It was established that binase at non-toxic concentrations (10 mu g/mL) reliably suppressed the migratory ability of HuTu 80 human duodenum adenocarcinoma cells incubated with RNase for 48-72 h. The antimetastatic potential of binase is confirmed by molecular modeling data demonstrating the ability of binase to inhibit cellular metalloproteinases that determine the migration of tumor cells.

KW - ribonuclease

KW - binase

KW - carcinoma

KW - melanoma

KW - invasion

KW - RAS oncogene

KW - ADAM metalloproteinases

KW - BINASE

KW - METALLOPROTEINASES

KW - PROLIFERATION

KW - TARGETS

KW - CANCER

KW - TUMOR

U2 - 10.1134/S0026893320010173

DO - 10.1134/S0026893320010173

M3 - Article

VL - 54

SP - 128

EP - 133

JO - Molecular Biology

JF - Molecular Biology

SN - 0026-8933

IS - 1

ER -

ID: 34669957