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Aqueous, Heterogeneous para-Hydrogen-Induced 15N Polarization. / Bales, Liana B.; Kovtunov, Kirill V.; Barskiy, Danila A. и др.

в: Journal of Physical Chemistry C, Том 121, № 28, 20.07.2017, стр. 15304-15309.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Bales, LB, Kovtunov, KV, Barskiy, DA, Shchepin, RV, Coffey, AM, Kovtunova, LM, Bukhtiyarov, AV, Feldman, MA, Bukhtiyarov, VI, Chekmenev, EY, Koptyug, IV & Goodson, BM 2017, 'Aqueous, Heterogeneous para-Hydrogen-Induced 15N Polarization', Journal of Physical Chemistry C, Том. 121, № 28, стр. 15304-15309. https://doi.org/10.1021/acs.jpcc.7b05912

APA

Bales, L. B., Kovtunov, K. V., Barskiy, D. A., Shchepin, R. V., Coffey, A. M., Kovtunova, L. M., Bukhtiyarov, A. V., Feldman, M. A., Bukhtiyarov, V. I., Chekmenev, E. Y., Koptyug, I. V., & Goodson, B. M. (2017). Aqueous, Heterogeneous para-Hydrogen-Induced 15N Polarization. Journal of Physical Chemistry C, 121(28), 15304-15309. https://doi.org/10.1021/acs.jpcc.7b05912

Vancouver

Bales LB, Kovtunov KV, Barskiy DA, Shchepin RV, Coffey AM, Kovtunova LM и др. Aqueous, Heterogeneous para-Hydrogen-Induced 15N Polarization. Journal of Physical Chemistry C. 2017 июль 20;121(28):15304-15309. doi: 10.1021/acs.jpcc.7b05912

Author

Bales, Liana B. ; Kovtunov, Kirill V. ; Barskiy, Danila A. и др. / Aqueous, Heterogeneous para-Hydrogen-Induced 15N Polarization. в: Journal of Physical Chemistry C. 2017 ; Том 121, № 28. стр. 15304-15309.

BibTeX

@article{c76b5e4026624b39850c4423ba71cef0,
title = "Aqueous, Heterogeneous para-Hydrogen-Induced 15N Polarization",
abstract = "The successful transfer of para-hydrogen-induced polarization to 15N spins using heterogeneous catalysts in aqueous solutions was demonstrated. Hydrogenation of a synthesized unsaturated 15N-labeled precursor (neurine) with parahydrogen (p-H2) over Rh/TiO2 heterogeneous catalysts yielded a hyperpolarized structural analogue of choline. As a result, 15N polarization enhancements of over 2 orders of magnitude were achieved for the 15N-labeled ethyltrimethylammonium ion product in deuterated water at elevated temperatures. Enhanced 15N NMR spectra were successfully acquired at 9.4 and 0.05 T. Importantly, long hyperpolarization lifetimes were observed at 9.4 T, with a 15N T1 of ∼6 min for the product molecules, and the T1 of the deuterated form exceeded 8 min. Taken together, these results show that this approach for generating hyperpolarized species with extended lifetimes in aqueous, biologically compatible solutions is promising for various biomedical applications.",
keywords = "DYNAMIC NUCLEAR-POLARIZATION, FIELD, HYPERPOLARIZED MAGNETIC-RESONANCE, IN-VIVO, MRI, NMR, PARAHYDROGEN-INDUCED POLARIZATION, PASADENA HYPERPOLARIZATION, REVERSIBLE EXCHANGE, SPIN ORDER",
author = "Bales, {Liana B.} and Kovtunov, {Kirill V.} and Barskiy, {Danila A.} and Shchepin, {Roman V.} and Coffey, {Aaron M.} and Kovtunova, {Larisa M.} and Bukhtiyarov, {Andrey V.} and Feldman, {Matthew A.} and Bukhtiyarov, {Valerii I.} and Chekmenev, {Eduard Y.} and Koptyug, {Igor V.} and Goodson, {Boyd M.}",
note = "Publisher Copyright: {\textcopyright} 2017 American Chemical Society.",
year = "2017",
month = jul,
day = "20",
doi = "10.1021/acs.jpcc.7b05912",
language = "English",
volume = "121",
pages = "15304--15309",
journal = "Journal of Physical Chemistry C",
issn = "1932-7447",
publisher = "American Chemical Society",
number = "28",

}

RIS

TY - JOUR

T1 - Aqueous, Heterogeneous para-Hydrogen-Induced 15N Polarization

AU - Bales, Liana B.

AU - Kovtunov, Kirill V.

AU - Barskiy, Danila A.

AU - Shchepin, Roman V.

AU - Coffey, Aaron M.

AU - Kovtunova, Larisa M.

AU - Bukhtiyarov, Andrey V.

AU - Feldman, Matthew A.

AU - Bukhtiyarov, Valerii I.

AU - Chekmenev, Eduard Y.

AU - Koptyug, Igor V.

AU - Goodson, Boyd M.

N1 - Publisher Copyright: © 2017 American Chemical Society.

PY - 2017/7/20

Y1 - 2017/7/20

N2 - The successful transfer of para-hydrogen-induced polarization to 15N spins using heterogeneous catalysts in aqueous solutions was demonstrated. Hydrogenation of a synthesized unsaturated 15N-labeled precursor (neurine) with parahydrogen (p-H2) over Rh/TiO2 heterogeneous catalysts yielded a hyperpolarized structural analogue of choline. As a result, 15N polarization enhancements of over 2 orders of magnitude were achieved for the 15N-labeled ethyltrimethylammonium ion product in deuterated water at elevated temperatures. Enhanced 15N NMR spectra were successfully acquired at 9.4 and 0.05 T. Importantly, long hyperpolarization lifetimes were observed at 9.4 T, with a 15N T1 of ∼6 min for the product molecules, and the T1 of the deuterated form exceeded 8 min. Taken together, these results show that this approach for generating hyperpolarized species with extended lifetimes in aqueous, biologically compatible solutions is promising for various biomedical applications.

AB - The successful transfer of para-hydrogen-induced polarization to 15N spins using heterogeneous catalysts in aqueous solutions was demonstrated. Hydrogenation of a synthesized unsaturated 15N-labeled precursor (neurine) with parahydrogen (p-H2) over Rh/TiO2 heterogeneous catalysts yielded a hyperpolarized structural analogue of choline. As a result, 15N polarization enhancements of over 2 orders of magnitude were achieved for the 15N-labeled ethyltrimethylammonium ion product in deuterated water at elevated temperatures. Enhanced 15N NMR spectra were successfully acquired at 9.4 and 0.05 T. Importantly, long hyperpolarization lifetimes were observed at 9.4 T, with a 15N T1 of ∼6 min for the product molecules, and the T1 of the deuterated form exceeded 8 min. Taken together, these results show that this approach for generating hyperpolarized species with extended lifetimes in aqueous, biologically compatible solutions is promising for various biomedical applications.

KW - DYNAMIC NUCLEAR-POLARIZATION

KW - FIELD

KW - HYPERPOLARIZED MAGNETIC-RESONANCE

KW - IN-VIVO

KW - MRI

KW - NMR

KW - PARAHYDROGEN-INDUCED POLARIZATION

KW - PASADENA HYPERPOLARIZATION

KW - REVERSIBLE EXCHANGE

KW - SPIN ORDER

UR - http://www.scopus.com/inward/record.url?scp=85025806660&partnerID=8YFLogxK

U2 - 10.1021/acs.jpcc.7b05912

DO - 10.1021/acs.jpcc.7b05912

M3 - Article

C2 - 29238438

AN - SCOPUS:85025806660

VL - 121

SP - 15304

EP - 15309

JO - Journal of Physical Chemistry C

JF - Journal of Physical Chemistry C

SN - 1932-7447

IS - 28

ER -

ID: 9055615