TY - JOUR

T1 - Anxiety, depression, and oscillatory dynamics in a social interaction model

AU - Knyazev, Gennady G.

AU - Savostyanov, Alexander N.

AU - Bocharov, Andrey V.

AU - Rimareva, Julia M.

PY - 2016/8/1

Y1 - 2016/8/1

N2 - Although anxiety and depression frequently co-occur and share a substantial part of genetic vulnerability and other risk factors, they are distinct disorders and their effect on social functioning and accompanying cognitive and emotional processing could be different. In this study, in a nonclinical sample, we compared effects of trait anxiety and depressive symptoms on oscillatory dynamics accompanying perception of emotional facial expressions in the context of social interactions. Anxiety was associated with a longer reaction time, with preference of avoidance behavior, and with enhanced event-related alpha desynchronization and diminished theta synchronization. Depression did not show significant behavioral effects and was associated with diminished alpha desynchronization and augmented delta and theta synchronization in prefrontal cortical regions. Thus, in spite of frequent comorbidity, anxiety and depression show opposite patterns of associations with oscillatory dynamics accompanying social interactions. These patterns imply that anxiety is associated with hyper-reactive attentional system, whereas depression show signs of diminished cognitive reactivity. Depression-related enhancement of low-frequency synchronization in prefrontal cortex may reflect a compensatory mechanism of cognitive and emotional upregulation, which depression-prone individuals engage in the process of social interactions.

AB - Although anxiety and depression frequently co-occur and share a substantial part of genetic vulnerability and other risk factors, they are distinct disorders and their effect on social functioning and accompanying cognitive and emotional processing could be different. In this study, in a nonclinical sample, we compared effects of trait anxiety and depressive symptoms on oscillatory dynamics accompanying perception of emotional facial expressions in the context of social interactions. Anxiety was associated with a longer reaction time, with preference of avoidance behavior, and with enhanced event-related alpha desynchronization and diminished theta synchronization. Depression did not show significant behavioral effects and was associated with diminished alpha desynchronization and augmented delta and theta synchronization in prefrontal cortical regions. Thus, in spite of frequent comorbidity, anxiety and depression show opposite patterns of associations with oscillatory dynamics accompanying social interactions. These patterns imply that anxiety is associated with hyper-reactive attentional system, whereas depression show signs of diminished cognitive reactivity. Depression-related enhancement of low-frequency synchronization in prefrontal cortex may reflect a compensatory mechanism of cognitive and emotional upregulation, which depression-prone individuals engage in the process of social interactions.

KW - Anxiety

KW - Connectivity

KW - Depression

KW - EEG

KW - Sloreta

KW - Social interactions

UR - http://www.scopus.com/inward/record.url?scp=84969794084&partnerID=8YFLogxK

U2 - 10.1016/j.brainres.2016.04.075

DO - 10.1016/j.brainres.2016.04.075

M3 - Article

C2 - 27173999

AN - SCOPUS:84969794084

VL - 1644

SP - 62

EP - 69

JO - Brain Research

JF - Brain Research

SN - 0006-8993

ER -