Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Antioxidative properties of nitroxyl radicals and hydroxyamines in reactions with triplet and deaminated kynurenine. / Yan'shole, V. V.; Kirilyuk, I. A.; Grigor'ev, I. A. и др.
в: Russian Chemical Bulletin, Том 59, № 1, 6, 01.2010, стр. 66-74.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Antioxidative properties of nitroxyl radicals and hydroxyamines in reactions with triplet and deaminated kynurenine
AU - Yan'shole, V. V.
AU - Kirilyuk, I. A.
AU - Grigor'ev, I. A.
AU - Morozov, S. V.
AU - Tsentalovich, Yu P.
N1 - This work was financially supported by the Federal Agency on Science and Innovations (State Contract No. 02.512.11.2278), the Russian Foundation for Basic Research (Project Nos 08 03 00539, 08 03 00432, and 07 03 00253), the Division of Chemistry and Materials Science of the Russian Academy of Sciences (Project No. 5.1.1), the Council on Grants at the President of the Russian Federation (State Support Program for Leading Scientific Schools, Grant NSh 3604.2008.3), the Russian Academy of Sciences (Program "Fundamental Sciences to Medicine," Project No. 22), and the Government of Moscow (Program "New Methods and Technologies of Early Diagnostics and Treatment of Oncological and Other Dangerous Diseases").
PY - 2010/1
Y1 - 2010/1
N2 - The reactions of triplet kynurenine and 4-(2-aminophenyl)-4-oxocrotonic acid, formed upon the thermal decomposition of kynurenine, with nitroxyl radicals and cyclic N-hydroxylamines were studied. Nitroxyl radicals were found to quench efficiently the triplet state of kynurenine (rate constant 3-6 ·108 L mol-1 s-1). The quenching proceeds via the spinexchange mechanism and affords no new products. Neither nitroxyl radicals, nor hydroxylamines react with 4-(2-aminophenyl)-4-oxocrotonic acid under conditions similar to physiological.
AB - The reactions of triplet kynurenine and 4-(2-aminophenyl)-4-oxocrotonic acid, formed upon the thermal decomposition of kynurenine, with nitroxyl radicals and cyclic N-hydroxylamines were studied. Nitroxyl radicals were found to quench efficiently the triplet state of kynurenine (rate constant 3-6 ·108 L mol-1 s-1). The quenching proceeds via the spinexchange mechanism and affords no new products. Neither nitroxyl radicals, nor hydroxylamines react with 4-(2-aminophenyl)-4-oxocrotonic acid under conditions similar to physiological.
KW - 4-(2-aminophenyl)-4-oxocrotonic acid
KW - Hydroxylamines
KW - Kynurenine
KW - Laser flash photolysis
KW - Nitroxyl radicals
KW - Quenching reactions
KW - Triplet excited state
UR - http://www.scopus.com/inward/record.url?scp=77955856339&partnerID=8YFLogxK
UR - https://www.elibrary.ru/item.asp?id=15329241
U2 - 10.1007/s11172-010-0046-y
DO - 10.1007/s11172-010-0046-y
M3 - Article
AN - SCOPUS:77955856339
VL - 59
SP - 66
EP - 74
JO - Russian Chemical Bulletin
JF - Russian Chemical Bulletin
SN - 1066-5285
IS - 1
M1 - 6
ER -
ID: 34424038