TY - GEN

T1 - Analysis of Continuous Glucose Monitoring Data in Patients with Type 1 Diabetes Managed with Continuous Subcutaneous Insulin Infusion During Hospital Stay and After Discharge from the Hospital

AU - Semenova, Julia F.

AU - Serebrov, Klim I.

AU - Koroleva, Elena A.

AU - Klimontov, Vadim V.

PY - 2024/11/26

Y1 - 2024/11/26

N2 - Background and Aim: The effectiveness of insulin therapy in a hospital setting and in the real life can vary significantly. The aim of this study was to analyze time in range (TIR) and glucose variability (GV) in patients with type 1 diabetes (T1D) treated with continuous subcutaneous insulin infusion (CSII) during inpatient treatment and after discharge from the hospital. Materials and Methods: The study included patients with type 1 diabetes (n=48) receiving insulin therapy in the CSII regimen. Flash Glucose Monitoring (FGM) or continuous glucose monitoring (CGM) was performed during the inpatient phase and for two weeks after hospital discharge. From the obtained FGM records, parameters were calculated that characterize the spread of glucose values, the amplitude of fluctuations, the rate of change in glucose levels, as well as many other indicators of glucose variability (GV) and time parameters in ranges (TIRs). Results: Most patients demonstrated deterioration of the glycemic control parameters after the hospital discharge. In the real-world settings, TIR values reduced, meanwhile Time Above Range (TAR) and Time Below Range (TBR) values increased when compared to those achieved in the hospital. Most patients did not achieve target TIR values. Conclusion: In patients with type 1 diabetes with newly initiated or adjusted CSII in a hospital setting, a deterioration in glycemic control parameters is observed in the first 2 weeks after discharge from the hospital. The results obtained must be taken into account in subsequent therapeutic training of patients.

AB - Background and Aim: The effectiveness of insulin therapy in a hospital setting and in the real life can vary significantly. The aim of this study was to analyze time in range (TIR) and glucose variability (GV) in patients with type 1 diabetes (T1D) treated with continuous subcutaneous insulin infusion (CSII) during inpatient treatment and after discharge from the hospital. Materials and Methods: The study included patients with type 1 diabetes (n=48) receiving insulin therapy in the CSII regimen. Flash Glucose Monitoring (FGM) or continuous glucose monitoring (CGM) was performed during the inpatient phase and for two weeks after hospital discharge. From the obtained FGM records, parameters were calculated that characterize the spread of glucose values, the amplitude of fluctuations, the rate of change in glucose levels, as well as many other indicators of glucose variability (GV) and time parameters in ranges (TIRs). Results: Most patients demonstrated deterioration of the glycemic control parameters after the hospital discharge. In the real-world settings, TIR values reduced, meanwhile Time Above Range (TAR) and Time Below Range (TBR) values increased when compared to those achieved in the hospital. Most patients did not achieve target TIR values. Conclusion: In patients with type 1 diabetes with newly initiated or adjusted CSII in a hospital setting, a deterioration in glycemic control parameters is observed in the first 2 weeks after discharge from the hospital. The results obtained must be taken into account in subsequent therapeutic training of patients.

KW - continuous glucose monitoring

KW - continuous subcutaneous insulin infusion

KW - flash glucose monitoring

KW - glucose variability

KW - time in range

KW - type 1 diabetes

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85212082134&origin=inward&txGid=b5a76a86ca5b6b0488954c74d79d24b8

UR - https://www.mendeley.com/catalogue/042bbbd9-36a2-3cdd-9838-bc66f3760229/

U2 - 10.1109/SIBIRCON63777.2024.10758522

DO - 10.1109/SIBIRCON63777.2024.10758522

M3 - Conference contribution

SN - 9798331532024

T3 - 2024 IEEE International Multi-Conference on Engineering, Computer and Information Sciences, SIBIRCON 2024

SP - 188

EP - 191

BT - 2024 IEEE International Multi-Conference on Engineering, Computer and Information Sciences, SIBIRCON 2024

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2024 IEEE International Multi-Conference on Engineering, Computer and Information Sciences

Y2 - 30 September 2024 through 2 November 2024

ER -