TY - JOUR

T1 - An hour in the morning is worth two in the evening: association of morning component of morningness–eveningness with single nucleotide polymorphisms in circadian clock genes

AU - Dorokhov, Vladimir B.

AU - Puchkova, Alexandra N.

AU - Taranov, Anton O.

AU - Slominsky, Petr A.

AU - Tupitsina, Tatiana V.

AU - Ivanov, Igor D.

AU - Vavilin, Valentin A.

AU - Nechunaev, Victor V.

AU - Kolomeichuk, Sergey N.

AU - Morozov, Artem V.

AU - Budkevich, Elena V.

AU - Budkevich, Roman O.

AU - Dementienko, Valeriy V.

AU - Sveshnikov, Dmitry S.

AU - Donskaya, Olga G.

AU - Putilov, Arcady A.

N1 - Funding Information: The studies of VBD, ANP, AOT, and PAS were supported by grants from the Russian Foundation for Humanities [grant numbers 15-06-10909a, 15-06-10874a, and 14-06-00963a]; SNK received support from the Federal Research Program [grant number 0221-2014-0034]; The studies of AAP and OGD were supported by grants from the Russian Foundation for Basic Research [grant numbers 07-06-00263-a, 10-06-00114-a, 13-06-00042-a, and 16-06-00235-a] and the Russian Foundation for Humanities [grant numbers 06-06-00375-a, 12-06-18001-e, and 15-06-10403-a]. Publisher Copyright: © 2017 Informa UK Limited, trading as Taylor & Francis Group.

PY - 2018/7/4

Y1 - 2018/7/4

N2 - Sub-constructs of morning–evening preference might be differentially related to polymorphisms in circadian clock genes. We previously reported significant association between a single nucleotide polymorphism in PER3 (rs2640909) and Morning but not Evening Lateness scale of the Sleep–Wake Pattern Assessment Questionnaire. To further explore such a scale-specific relationship, seven single nucleotide polymorphisms in five circadian clock genes were studied using exploratory and confirmatory samples (in total, n = 698). The association of rs2640909 with Morning Lateness scale was not replicated in the confirmatory sample but remained significant in the merged sample. Moreover, we found and confirmed an association of this scale with rs1159814 in RORα. The results provided further evidence for differential relationship of polymorphisms in circadian clock genes with morning and evening components of morning–evening preference. We also suggested possibility to take into account the pattern of geographic variation in allele frequency for prioritization of circadian clock polymorphisms in candidate gene studies.

AB - Sub-constructs of morning–evening preference might be differentially related to polymorphisms in circadian clock genes. We previously reported significant association between a single nucleotide polymorphism in PER3 (rs2640909) and Morning but not Evening Lateness scale of the Sleep–Wake Pattern Assessment Questionnaire. To further explore such a scale-specific relationship, seven single nucleotide polymorphisms in five circadian clock genes were studied using exploratory and confirmatory samples (in total, n = 698). The association of rs2640909 with Morning Lateness scale was not replicated in the confirmatory sample but remained significant in the merged sample. Moreover, we found and confirmed an association of this scale with rs1159814 in RORα. The results provided further evidence for differential relationship of polymorphisms in circadian clock genes with morning and evening components of morning–evening preference. We also suggested possibility to take into account the pattern of geographic variation in allele frequency for prioritization of circadian clock polymorphisms in candidate gene studies.

KW - candidate gene

KW - chronotype

KW - CLOCK

KW - NPAS2

KW - PER2

KW - PER3

KW - RORA

KW - SNPs

UR - http://www.scopus.com/inward/record.url?scp=85031917660&partnerID=8YFLogxK

U2 - 10.1080/09291016.2017.1390823

DO - 10.1080/09291016.2017.1390823

M3 - Article

AN - SCOPUS:85031917660

VL - 49

SP - 622

EP - 642

JO - Biological Rhythm Research

JF - Biological Rhythm Research

SN - 0929-1016

IS - 4

ER -