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Activity of DNA Repair Systems in the Cells of Long-Lived Rodents and Bats. / Popov, Aleksei A.; Petruseva, Irina O.; Lavrik, Olga I.

в: Biochemistry (Moscow), Том 89, № 6, 06.2024, стр. 1014-1023.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Popov, AA, Petruseva, IO & Lavrik, OI 2024, 'Activity of DNA Repair Systems in the Cells of Long-Lived Rodents and Bats', Biochemistry (Moscow), Том. 89, № 6, стр. 1014-1023. https://doi.org/10.1134/S0006297924060038

APA

Popov, A. A., Petruseva, I. O., & Lavrik, O. I. (2024). Activity of DNA Repair Systems in the Cells of Long-Lived Rodents and Bats. Biochemistry (Moscow), 89(6), 1014-1023. https://doi.org/10.1134/S0006297924060038

Vancouver

Popov AA, Petruseva IO, Lavrik OI. Activity of DNA Repair Systems in the Cells of Long-Lived Rodents and Bats. Biochemistry (Moscow). 2024 июнь;89(6):1014-1023. doi: 10.1134/S0006297924060038

Author

Popov, Aleksei A. ; Petruseva, Irina O. ; Lavrik, Olga I. / Activity of DNA Repair Systems in the Cells of Long-Lived Rodents and Bats. в: Biochemistry (Moscow). 2024 ; Том 89, № 6. стр. 1014-1023.

BibTeX

@article{701fc77c6b1b47aeaf6279d43094b1fe,
title = "Activity of DNA Repair Systems in the Cells of Long-Lived Rodents and Bats",
abstract = "Damages of various origin accumulated in the genomic DNA can lead to the breach of genome stability, and are considered to be one of the main factors involved in cellular senescence. DNA repair systems in mammalian cells ensure effective damage removal and repair of the genome structure, therefore, activity of these systems is expected to be correlated with high maximum lifespan observed in the long-lived mammals. This review discusses current results of the studies focused on determination of the DNA repair system activity and investigation of the properties of its key regulatory proteins in the cells of long-lived rodents and bats. Based on the works discussed in the review, it could be concluded that the long-lived rodents and bats in general demonstrate high efficiency in functioning and regulation of DNA repair systems. Nevertheless, a number of questions around the study of DNA repair in the cells of long-lived rodents and bats remain poorly understood, answers to which could open up new avenues for further research.",
keywords = "DNA repair, cellular senescence, longevity, poly(ADP-ribose)polymerase 1, sirtuin 6, Animals, DNA Repair, Rodentia/genetics, Chiroptera/genetics, DNA Damage, Longevity",
author = "Popov, {Aleksei A.} and Petruseva, {Irina O.} and Lavrik, {Olga I.}",
note = "This work was financially supported by the Russian Science Foundation (project no. 19-74-10056-P).",
year = "2024",
month = jun,
doi = "10.1134/S0006297924060038",
language = "English",
volume = "89",
pages = "1014--1023",
journal = "Biochemistry (Moscow)",
issn = "0006-2979",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "6",

}

RIS

TY - JOUR

T1 - Activity of DNA Repair Systems in the Cells of Long-Lived Rodents and Bats

AU - Popov, Aleksei A.

AU - Petruseva, Irina O.

AU - Lavrik, Olga I.

N1 - This work was financially supported by the Russian Science Foundation (project no. 19-74-10056-P).

PY - 2024/6

Y1 - 2024/6

N2 - Damages of various origin accumulated in the genomic DNA can lead to the breach of genome stability, and are considered to be one of the main factors involved in cellular senescence. DNA repair systems in mammalian cells ensure effective damage removal and repair of the genome structure, therefore, activity of these systems is expected to be correlated with high maximum lifespan observed in the long-lived mammals. This review discusses current results of the studies focused on determination of the DNA repair system activity and investigation of the properties of its key regulatory proteins in the cells of long-lived rodents and bats. Based on the works discussed in the review, it could be concluded that the long-lived rodents and bats in general demonstrate high efficiency in functioning and regulation of DNA repair systems. Nevertheless, a number of questions around the study of DNA repair in the cells of long-lived rodents and bats remain poorly understood, answers to which could open up new avenues for further research.

AB - Damages of various origin accumulated in the genomic DNA can lead to the breach of genome stability, and are considered to be one of the main factors involved in cellular senescence. DNA repair systems in mammalian cells ensure effective damage removal and repair of the genome structure, therefore, activity of these systems is expected to be correlated with high maximum lifespan observed in the long-lived mammals. This review discusses current results of the studies focused on determination of the DNA repair system activity and investigation of the properties of its key regulatory proteins in the cells of long-lived rodents and bats. Based on the works discussed in the review, it could be concluded that the long-lived rodents and bats in general demonstrate high efficiency in functioning and regulation of DNA repair systems. Nevertheless, a number of questions around the study of DNA repair in the cells of long-lived rodents and bats remain poorly understood, answers to which could open up new avenues for further research.

KW - DNA repair

KW - cellular senescence

KW - longevity

KW - poly(ADP-ribose)polymerase 1

KW - sirtuin 6

KW - Animals

KW - DNA Repair

KW - Rodentia/genetics

KW - Chiroptera/genetics

KW - DNA Damage

KW - Longevity

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85197504132&origin=inward&txGid=fe50ccf47c815633d25193fd97975bcd

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001263122400012

UR - https://www.mendeley.com/catalogue/db2e7105-abc2-35bf-955b-295f9169b7e3/

U2 - 10.1134/S0006297924060038

DO - 10.1134/S0006297924060038

M3 - Article

C2 - 38981697

VL - 89

SP - 1014

EP - 1023

JO - Biochemistry (Moscow)

JF - Biochemistry (Moscow)

SN - 0006-2979

IS - 6

ER -

ID: 61165663