TY - JOUR

T1 - Activity of Digestive Enzymes in the American Mink (Neovison vison) Selected for Tameness and Defensive Aggression toward Humans

AU - Kalinina, S. N.

AU - Ilyukha, V. A.

AU - Trapezov, O.

AU - Morozov, A.

AU - Trapezova, L.

AU - Nekrasova, M. A.

AU - Stepanova, M. A.

AU - Sysoeva, E. A.

N1 - This work was supported by the Federal budget within the assignment to the IB FRC KarRC RAS (FMEN20220003) and the ICG SB RAS project No. 025920210015.

PY - 2022/1

Y1 - 2022/1

N2 - Selection of animals for a defensive reaction toward humans underlies the domestication of species and leads to genome destabilization, as well as restructuring of the nervous and hormonal systems that regulate many physiological functions, including digestion . The aim was to study the activity of digestive enzymes (amylase, lipase and proteases) in the pancreas, duodenum and jejunum of the American mink (Neovison vison) of two behavioral types, aggressive and tame. Our findings suggest that pleiotropic effects of behavioral genes are also involved in the regulation of digestive enzyme activity in the American mink. Despite the same diet, aggressive vs. tame animals were characterized by a higher activity of proteases and lipase, whereas in tame minks, the amylolytic profile of digestive enzyme activity was predominant. Discriminant analysis confirmed the differences between aggressive and tame minks, but not between the two groups of aggressive animals, in terms of the parameters studied. The revealed differences in the profile of the activity of digestive enzymes can be associated with mutations in the enzyme genes, as well as mediated action of hormones involved in stress reactivity.

AB - Selection of animals for a defensive reaction toward humans underlies the domestication of species and leads to genome destabilization, as well as restructuring of the nervous and hormonal systems that regulate many physiological functions, including digestion . The aim was to study the activity of digestive enzymes (amylase, lipase and proteases) in the pancreas, duodenum and jejunum of the American mink (Neovison vison) of two behavioral types, aggressive and tame. Our findings suggest that pleiotropic effects of behavioral genes are also involved in the regulation of digestive enzyme activity in the American mink. Despite the same diet, aggressive vs. tame animals were characterized by a higher activity of proteases and lipase, whereas in tame minks, the amylolytic profile of digestive enzyme activity was predominant. Discriminant analysis confirmed the differences between aggressive and tame minks, but not between the two groups of aggressive animals, in terms of the parameters studied. The revealed differences in the profile of the activity of digestive enzymes can be associated with mutations in the enzyme genes, as well as mediated action of hormones involved in stress reactivity.

KW - American mink

KW - selection for a defensive response to humans

KW - amylase

KW - protease

KW - lipase

KW - gastrointestinal tract

KW - hypothalamic-pituitary-adrenal axis

KW - BEHAVIOR

KW - ADAPTATION

KW - METABOLISM

KW - DIET

U2 - 10.1134/S0022093022010069

DO - 10.1134/S0022093022010069

M3 - Article

VL - 58

SP - 64

EP - 72

JO - Journal of Evolutionary Biochemistry and Physiology

JF - Journal of Evolutionary Biochemistry and Physiology

SN - 0022-0930

IS - 1

ER -