TY - JOUR

T1 - A modular visual model of energy metabolism in human skeletal muscle

AU - Kiselev, I. N.

AU - Akberdin, I. R.

AU - Vertyshev, A. Yu

AU - D.V., Popov

AU - Kolpakov, F. A.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - The paper presents a modification of a multi-compartmental mathematical model describing the dynamics of intracellular species concentrations and fluxes in human muscle at rest. A modular representation of a complex model is proposed, which provides the possibility of rapid expansion and modification of the model compartments to account for the complex organization of muscle cells and the limitations of the rate of diffusion of metabolites between intracellular compartments. To illustrate the work of the model, intracellular response in human skeletal muscle to acute aerobic two-legged cycle ergometer training was considered.

AB - The paper presents a modification of a multi-compartmental mathematical model describing the dynamics of intracellular species concentrations and fluxes in human muscle at rest. A modular representation of a complex model is proposed, which provides the possibility of rapid expansion and modification of the model compartments to account for the complex organization of muscle cells and the limitations of the rate of diffusion of metabolites between intracellular compartments. To illustrate the work of the model, intracellular response in human skeletal muscle to acute aerobic two-legged cycle ergometer training was considered.

KW - BioUML

KW - Mathematical model

KW - Metabolism

KW - Module modeling approach

KW - Physical exercise

KW - Physiology

KW - Skeletal muscle

UR - http://www.scopus.com/inward/record.url?scp=85072340586&partnerID=8YFLogxK

UR - https://www.elibrary.ru/item.asp?id=42429005

U2 - 10.17537/2019.14.373

DO - 10.17537/2019.14.373

M3 - Article

AN - SCOPUS:85072340586

VL - 14

SP - 373

EP - 392

JO - Mathematical Biology and Bioinformatics

JF - Mathematical Biology and Bioinformatics

SN - 1994-6538

IS - 2

ER -