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15N MRI of SLIC-SABRE Hyperpolarized 15N-Labelled Pyridine and Nicotinamide. / Svyatova, Alexandra; Skovpin, Ivan V.; Chukanov, Nikita V. и др.

в: Chemistry - A European Journal, Том 25, № 36, 26.06.2019, стр. 8465-8470.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Svyatova, A, Skovpin, IV, Chukanov, NV, Kovtunov, KV, Chekmenev, EY, Pravdivtsev, AN, Hövener, JB & Koptyug, IV 2019, '15N MRI of SLIC-SABRE Hyperpolarized 15N-Labelled Pyridine and Nicotinamide', Chemistry - A European Journal, Том. 25, № 36, стр. 8465-8470. https://doi.org/10.1002/chem.201900430

APA

Svyatova, A., Skovpin, I. V., Chukanov, N. V., Kovtunov, K. V., Chekmenev, E. Y., Pravdivtsev, A. N., Hövener, J. B., & Koptyug, I. V. (2019). 15N MRI of SLIC-SABRE Hyperpolarized 15N-Labelled Pyridine and Nicotinamide. Chemistry - A European Journal, 25(36), 8465-8470. https://doi.org/10.1002/chem.201900430

Vancouver

Svyatova A, Skovpin IV, Chukanov NV, Kovtunov KV, Chekmenev EY, Pravdivtsev AN и др. 15N MRI of SLIC-SABRE Hyperpolarized 15N-Labelled Pyridine and Nicotinamide. Chemistry - A European Journal. 2019 июнь 26;25(36):8465-8470. doi: 10.1002/chem.201900430

Author

Svyatova, Alexandra ; Skovpin, Ivan V. ; Chukanov, Nikita V. и др. / 15N MRI of SLIC-SABRE Hyperpolarized 15N-Labelled Pyridine and Nicotinamide. в: Chemistry - A European Journal. 2019 ; Том 25, № 36. стр. 8465-8470.

BibTeX

@article{1dbec4e22f224c70bbd571dba577ffb7,
title = "15N MRI of SLIC-SABRE Hyperpolarized 15N-Labelled Pyridine and Nicotinamide",
abstract = "Magnetic Resonance Imaging (MRI) is a powerful non-invasive diagnostic method extensively used in biomedical studies. A significant limitation of MRI is its relatively low signal-to-noise ratio, which can be increased by hyperpolarizing nuclear spins. One promising method is Signal Amplification By Reversible Exchange (SABRE), which employs parahydrogen as a source of hyperpolarization. Recent studies demonstrated the feasibility to improve MRI sensitivity with this hyperpolarization technique. Hyperpolarized 15N nuclei in biomolecules can potentially retain their spin alignment for tens of minutes, providing an extended time window for the utilization of the hyperpolarized compounds. In this work, we demonstrate for the first time that radio-frequency-based SABRE hyperpolarization techniques can be used to obtain 15N MRI of biomolecule 1-15N-nicotinamide. Two image acquisition strategies were utilized and compared: Single Point Imaging (SPI) and Fast Low Angle SHot (FLASH). These methods demonstrated opportunities of high-field SABRE for biomedical applications.",
keywords = "N MRI, hyperpolarization, molecular imaging, parahydrogen, SABRE, Nitrogen Isotopes/chemistry, Pyridines/chemistry, Isotope Labeling, Magnetic Resonance Imaging/methods, Catalysis, Niacinamide/chemistry, Coordination Complexes/chemistry, MAGNETIZATION, HIGH-FIELD, N-15 MRI, PARAHYDROGEN, SIGNAL AMPLIFICATION, REVERSIBLE EXCHANGE, NMR, SPECTROSCOPY, METRONIDAZOLE, POLARIZATION, IN-SITU",
author = "Alexandra Svyatova and Skovpin, {Ivan V.} and Chukanov, {Nikita V.} and Kovtunov, {Kirill V.} and Chekmenev, {Eduard Y.} and Pravdivtsev, {Andrey N.} and H{\"o}vener, {Jan Bernd} and Koptyug, {Igor V.}",
note = "{\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.",
year = "2019",
month = jun,
day = "26",
doi = "10.1002/chem.201900430",
language = "English",
volume = "25",
pages = "8465--8470",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "36",

}

RIS

TY - JOUR

T1 - 15N MRI of SLIC-SABRE Hyperpolarized 15N-Labelled Pyridine and Nicotinamide

AU - Svyatova, Alexandra

AU - Skovpin, Ivan V.

AU - Chukanov, Nikita V.

AU - Kovtunov, Kirill V.

AU - Chekmenev, Eduard Y.

AU - Pravdivtsev, Andrey N.

AU - Hövener, Jan Bernd

AU - Koptyug, Igor V.

N1 - © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

PY - 2019/6/26

Y1 - 2019/6/26

N2 - Magnetic Resonance Imaging (MRI) is a powerful non-invasive diagnostic method extensively used in biomedical studies. A significant limitation of MRI is its relatively low signal-to-noise ratio, which can be increased by hyperpolarizing nuclear spins. One promising method is Signal Amplification By Reversible Exchange (SABRE), which employs parahydrogen as a source of hyperpolarization. Recent studies demonstrated the feasibility to improve MRI sensitivity with this hyperpolarization technique. Hyperpolarized 15N nuclei in biomolecules can potentially retain their spin alignment for tens of minutes, providing an extended time window for the utilization of the hyperpolarized compounds. In this work, we demonstrate for the first time that radio-frequency-based SABRE hyperpolarization techniques can be used to obtain 15N MRI of biomolecule 1-15N-nicotinamide. Two image acquisition strategies were utilized and compared: Single Point Imaging (SPI) and Fast Low Angle SHot (FLASH). These methods demonstrated opportunities of high-field SABRE for biomedical applications.

AB - Magnetic Resonance Imaging (MRI) is a powerful non-invasive diagnostic method extensively used in biomedical studies. A significant limitation of MRI is its relatively low signal-to-noise ratio, which can be increased by hyperpolarizing nuclear spins. One promising method is Signal Amplification By Reversible Exchange (SABRE), which employs parahydrogen as a source of hyperpolarization. Recent studies demonstrated the feasibility to improve MRI sensitivity with this hyperpolarization technique. Hyperpolarized 15N nuclei in biomolecules can potentially retain their spin alignment for tens of minutes, providing an extended time window for the utilization of the hyperpolarized compounds. In this work, we demonstrate for the first time that radio-frequency-based SABRE hyperpolarization techniques can be used to obtain 15N MRI of biomolecule 1-15N-nicotinamide. Two image acquisition strategies were utilized and compared: Single Point Imaging (SPI) and Fast Low Angle SHot (FLASH). These methods demonstrated opportunities of high-field SABRE for biomedical applications.

KW - N MRI

KW - hyperpolarization

KW - molecular imaging

KW - parahydrogen

KW - SABRE

KW - Nitrogen Isotopes/chemistry

KW - Pyridines/chemistry

KW - Isotope Labeling

KW - Magnetic Resonance Imaging/methods

KW - Catalysis

KW - Niacinamide/chemistry

KW - Coordination Complexes/chemistry

KW - MAGNETIZATION

KW - HIGH-FIELD

KW - N-15 MRI

KW - PARAHYDROGEN

KW - SIGNAL AMPLIFICATION

KW - REVERSIBLE EXCHANGE

KW - NMR

KW - SPECTROSCOPY

KW - METRONIDAZOLE

KW - POLARIZATION

KW - IN-SITU

UR - http://www.scopus.com/inward/record.url?scp=85068782757&partnerID=8YFLogxK

U2 - 10.1002/chem.201900430

DO - 10.1002/chem.201900430

M3 - Article

C2 - 30950529

AN - SCOPUS:85068782757

VL - 25

SP - 8465

EP - 8470

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 36

ER -

ID: 20825880