Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
15N MRI of SLIC-SABRE Hyperpolarized 15N-Labelled Pyridine and Nicotinamide. / Svyatova, Alexandra; Skovpin, Ivan V.; Chukanov, Nikita V. и др.
в: Chemistry - A European Journal, Том 25, № 36, 26.06.2019, стр. 8465-8470.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - 15N MRI of SLIC-SABRE Hyperpolarized 15N-Labelled Pyridine and Nicotinamide
AU - Svyatova, Alexandra
AU - Skovpin, Ivan V.
AU - Chukanov, Nikita V.
AU - Kovtunov, Kirill V.
AU - Chekmenev, Eduard Y.
AU - Pravdivtsev, Andrey N.
AU - Hövener, Jan Bernd
AU - Koptyug, Igor V.
N1 - © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
PY - 2019/6/26
Y1 - 2019/6/26
N2 - Magnetic Resonance Imaging (MRI) is a powerful non-invasive diagnostic method extensively used in biomedical studies. A significant limitation of MRI is its relatively low signal-to-noise ratio, which can be increased by hyperpolarizing nuclear spins. One promising method is Signal Amplification By Reversible Exchange (SABRE), which employs parahydrogen as a source of hyperpolarization. Recent studies demonstrated the feasibility to improve MRI sensitivity with this hyperpolarization technique. Hyperpolarized 15N nuclei in biomolecules can potentially retain their spin alignment for tens of minutes, providing an extended time window for the utilization of the hyperpolarized compounds. In this work, we demonstrate for the first time that radio-frequency-based SABRE hyperpolarization techniques can be used to obtain 15N MRI of biomolecule 1-15N-nicotinamide. Two image acquisition strategies were utilized and compared: Single Point Imaging (SPI) and Fast Low Angle SHot (FLASH). These methods demonstrated opportunities of high-field SABRE for biomedical applications.
AB - Magnetic Resonance Imaging (MRI) is a powerful non-invasive diagnostic method extensively used in biomedical studies. A significant limitation of MRI is its relatively low signal-to-noise ratio, which can be increased by hyperpolarizing nuclear spins. One promising method is Signal Amplification By Reversible Exchange (SABRE), which employs parahydrogen as a source of hyperpolarization. Recent studies demonstrated the feasibility to improve MRI sensitivity with this hyperpolarization technique. Hyperpolarized 15N nuclei in biomolecules can potentially retain their spin alignment for tens of minutes, providing an extended time window for the utilization of the hyperpolarized compounds. In this work, we demonstrate for the first time that radio-frequency-based SABRE hyperpolarization techniques can be used to obtain 15N MRI of biomolecule 1-15N-nicotinamide. Two image acquisition strategies were utilized and compared: Single Point Imaging (SPI) and Fast Low Angle SHot (FLASH). These methods demonstrated opportunities of high-field SABRE for biomedical applications.
KW - N MRI
KW - hyperpolarization
KW - molecular imaging
KW - parahydrogen
KW - SABRE
KW - Nitrogen Isotopes/chemistry
KW - Pyridines/chemistry
KW - Isotope Labeling
KW - Magnetic Resonance Imaging/methods
KW - Catalysis
KW - Niacinamide/chemistry
KW - Coordination Complexes/chemistry
KW - MAGNETIZATION
KW - HIGH-FIELD
KW - N-15 MRI
KW - PARAHYDROGEN
KW - SIGNAL AMPLIFICATION
KW - REVERSIBLE EXCHANGE
KW - NMR
KW - SPECTROSCOPY
KW - METRONIDAZOLE
KW - POLARIZATION
KW - IN-SITU
UR - http://www.scopus.com/inward/record.url?scp=85068782757&partnerID=8YFLogxK
U2 - 10.1002/chem.201900430
DO - 10.1002/chem.201900430
M3 - Article
C2 - 30950529
AN - SCOPUS:85068782757
VL - 25
SP - 8465
EP - 8470
JO - Chemistry - A European Journal
JF - Chemistry - A European Journal
SN - 0947-6539
IS - 36
ER -
ID: 20825880