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15N Hyperpolarization of Dalfampridine at Natural Abundance for Magnetic Resonance Imaging. / Skovpin, Ivan V.; Svyatova, Alexandra; Chukanov, Nikita и др.

в: Chemistry - A European Journal, Том 25, № 55, 23.07.2019, стр. 12694-12697.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Skovpin, IV, Svyatova, A, Chukanov, N, Chekmenev, EY, Kovtunov, KV & Koptyug, IV 2019, '15N Hyperpolarization of Dalfampridine at Natural Abundance for Magnetic Resonance Imaging', Chemistry - A European Journal, Том. 25, № 55, стр. 12694-12697. https://doi.org/10.1002/chem.201902724

APA

Skovpin, I. V., Svyatova, A., Chukanov, N., Chekmenev, E. Y., Kovtunov, K. V., & Koptyug, I. V. (2019). 15N Hyperpolarization of Dalfampridine at Natural Abundance for Magnetic Resonance Imaging. Chemistry - A European Journal, 25(55), 12694-12697. https://doi.org/10.1002/chem.201902724

Vancouver

Skovpin IV, Svyatova A, Chukanov N, Chekmenev EY, Kovtunov KV, Koptyug IV. 15N Hyperpolarization of Dalfampridine at Natural Abundance for Magnetic Resonance Imaging. Chemistry - A European Journal. 2019 июль 23;25(55):12694-12697. doi: 10.1002/chem.201902724

Author

Skovpin, Ivan V. ; Svyatova, Alexandra ; Chukanov, Nikita и др. / 15N Hyperpolarization of Dalfampridine at Natural Abundance for Magnetic Resonance Imaging. в: Chemistry - A European Journal. 2019 ; Том 25, № 55. стр. 12694-12697.

BibTeX

@article{37070c62264d4cc4abc70cfd5e7a564a,
title = "15N Hyperpolarization of Dalfampridine at Natural Abundance for Magnetic Resonance Imaging",
abstract = "Signal Amplification by Reversible Exchange (SABRE) is a promising method for NMR signal enhancement and production of hyperpolarized molecules. As nuclear spin relaxation times of heteronuclei are usually much longer than those of protons, SABRE-based hyperpolarization of heteronuclei in molecules is highly important in the context of biomedical applications. In this work, we demonstrate that the SLIC-SABRE technique can be successfully used to hyperpolarize 15N nuclei in dalfampridine. The high polarization level of ca. 8 % achieved in this work made it possible to acquire 15N MR images at natural abundance of the 15N nuclei for the first time.",
keywords = "N natural abundance, hyperpolarization, MRI, parahydrogen, SABRE, SENSITIVITY, PARAHYDROGEN, SIGNAL AMPLIFICATION, REVERSIBLE EXCHANGE, NMR, ENHANCEMENT, METRONIDAZOLE, CATALYSTS, N-15 natural abundance",
author = "Skovpin, {Ivan V.} and Alexandra Svyatova and Nikita Chukanov and Chekmenev, {Eduard Y.} and Kovtunov, {Kirill V.} and Koptyug, {Igor V.}",
note = "Publisher Copyright: {\textcopyright} 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim",
year = "2019",
month = jul,
day = "23",
doi = "10.1002/chem.201902724",
language = "English",
volume = "25",
pages = "12694--12697",
journal = "Chemistry - A European Journal",
issn = "0947-6539",
publisher = "Wiley-VCH Verlag",
number = "55",

}

RIS

TY - JOUR

T1 - 15N Hyperpolarization of Dalfampridine at Natural Abundance for Magnetic Resonance Imaging

AU - Skovpin, Ivan V.

AU - Svyatova, Alexandra

AU - Chukanov, Nikita

AU - Chekmenev, Eduard Y.

AU - Kovtunov, Kirill V.

AU - Koptyug, Igor V.

N1 - Publisher Copyright: © 2019 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

PY - 2019/7/23

Y1 - 2019/7/23

N2 - Signal Amplification by Reversible Exchange (SABRE) is a promising method for NMR signal enhancement and production of hyperpolarized molecules. As nuclear spin relaxation times of heteronuclei are usually much longer than those of protons, SABRE-based hyperpolarization of heteronuclei in molecules is highly important in the context of biomedical applications. In this work, we demonstrate that the SLIC-SABRE technique can be successfully used to hyperpolarize 15N nuclei in dalfampridine. The high polarization level of ca. 8 % achieved in this work made it possible to acquire 15N MR images at natural abundance of the 15N nuclei for the first time.

AB - Signal Amplification by Reversible Exchange (SABRE) is a promising method for NMR signal enhancement and production of hyperpolarized molecules. As nuclear spin relaxation times of heteronuclei are usually much longer than those of protons, SABRE-based hyperpolarization of heteronuclei in molecules is highly important in the context of biomedical applications. In this work, we demonstrate that the SLIC-SABRE technique can be successfully used to hyperpolarize 15N nuclei in dalfampridine. The high polarization level of ca. 8 % achieved in this work made it possible to acquire 15N MR images at natural abundance of the 15N nuclei for the first time.

KW - N natural abundance

KW - hyperpolarization

KW - MRI

KW - parahydrogen

KW - SABRE

KW - SENSITIVITY

KW - PARAHYDROGEN

KW - SIGNAL AMPLIFICATION

KW - REVERSIBLE EXCHANGE

KW - NMR

KW - ENHANCEMENT

KW - METRONIDAZOLE

KW - CATALYSTS

KW - N-15 natural abundance

UR - http://www.scopus.com/inward/record.url?scp=85071924774&partnerID=8YFLogxK

U2 - 10.1002/chem.201902724

DO - 10.1002/chem.201902724

M3 - Article

C2 - 31338889

AN - SCOPUS:85071924774

VL - 25

SP - 12694

EP - 12697

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

SN - 0947-6539

IS - 55

ER -

ID: 21467053