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Y-box-binding protein 1 stimulates abasic site cleavage. / Alemasova, E. E.; Naumenko, K. N.; Moor, N. A. et al.

In: Biochemistry (Moscow), Vol. 82, No. 12, 01.12.2017, p. 1521-1528.

Research output: Contribution to journal › Article › peer-review

Harvard

Alemasova, EE, Naumenko, KN, Moor, NA & Lavrik, OI 2017, 'Y-box-binding protein 1 stimulates abasic site cleavage', Biochemistry (Moscow), vol. 82, no. 12, pp. 1521-1528. https://doi.org/10.1134/S0006297917120112

APA

Alemasova, E. E., Naumenko, K. N., Moor, N. A., & Lavrik, O. I. (2017). Y-box-binding protein 1 stimulates abasic site cleavage. Biochemistry (Moscow), 82(12), 1521-1528. https://doi.org/10.1134/S0006297917120112

Vancouver

Alemasova EE, Naumenko KN, Moor NA, Lavrik OI. Y-box-binding protein 1 stimulates abasic site cleavage. Biochemistry (Moscow). 2017 Dec 1;82(12):1521-1528. doi: 10.1134/S0006297917120112

Author

Alemasova, E. E. ; Naumenko, K. N. ; Moor, N. A. et al. / Y-box-binding protein 1 stimulates abasic site cleavage. In: Biochemistry (Moscow). 2017 ; Vol. 82, No. 12. pp. 1521-1528.

BibTeX

@article{e97e354a8c294484a97638a46b34fa0e,
title = "Y-box-binding protein 1 stimulates abasic site cleavage",
abstract = "Apurinic/apyrimidinic (AP) sites are among the most frequent DNA lesions. The first step in the AP site repair involves the magnesium-dependent enzyme AP endonuclease 1 (APE1) that catalyzes hydrolytic cleavage of the DNA phosphodiester bond at the 5′ side of the AP site, thereby generating a single-strand DNA break flanked by the 3′-OH and 5′-deoxyribose phosphate (dRP) groups. Increased APE1 activity in cancer cells might correlate with tumor chemoresistance to DNA-damaging treatment. It has been previously shown that the multifunctional oncoprotein Y-box-binding protein 1 (YB-1) interacts with APE1 and inhibits APE1-catalyzed hydrolysis of AP sites in single-stranded DNAs. In this work, we demonstrated that YB-1 stabilizes the APE1 complex with double-stranded DNAs containing the AP sites and stimulates cleavage of these AP sites at low magnesium concentrations.",
keywords = "AP endonuclease 1, apurinic/apyrimidinic site, base excision repair, Y-box-binding protein 1",
author = "Alemasova, {E. E.} and Naumenko, {K. N.} and Moor, {N. A.} and Lavrik, {O. I.}",
year = "2017",
month = dec,
day = "1",
doi = "10.1134/S0006297917120112",
language = "English",
volume = "82",
pages = "1521--1528",
journal = "Biochemistry (Moscow)",
issn = "0006-2979",
publisher = "Maik Nauka-Interperiodica Publishing",
number = "12",

}

RIS

TY - JOUR

T1 - Y-box-binding protein 1 stimulates abasic site cleavage

AU - Alemasova, E. E.

AU - Naumenko, K. N.

AU - Moor, N. A.

AU - Lavrik, O. I.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Apurinic/apyrimidinic (AP) sites are among the most frequent DNA lesions. The first step in the AP site repair involves the magnesium-dependent enzyme AP endonuclease 1 (APE1) that catalyzes hydrolytic cleavage of the DNA phosphodiester bond at the 5′ side of the AP site, thereby generating a single-strand DNA break flanked by the 3′-OH and 5′-deoxyribose phosphate (dRP) groups. Increased APE1 activity in cancer cells might correlate with tumor chemoresistance to DNA-damaging treatment. It has been previously shown that the multifunctional oncoprotein Y-box-binding protein 1 (YB-1) interacts with APE1 and inhibits APE1-catalyzed hydrolysis of AP sites in single-stranded DNAs. In this work, we demonstrated that YB-1 stabilizes the APE1 complex with double-stranded DNAs containing the AP sites and stimulates cleavage of these AP sites at low magnesium concentrations.

AB - Apurinic/apyrimidinic (AP) sites are among the most frequent DNA lesions. The first step in the AP site repair involves the magnesium-dependent enzyme AP endonuclease 1 (APE1) that catalyzes hydrolytic cleavage of the DNA phosphodiester bond at the 5′ side of the AP site, thereby generating a single-strand DNA break flanked by the 3′-OH and 5′-deoxyribose phosphate (dRP) groups. Increased APE1 activity in cancer cells might correlate with tumor chemoresistance to DNA-damaging treatment. It has been previously shown that the multifunctional oncoprotein Y-box-binding protein 1 (YB-1) interacts with APE1 and inhibits APE1-catalyzed hydrolysis of AP sites in single-stranded DNAs. In this work, we demonstrated that YB-1 stabilizes the APE1 complex with double-stranded DNAs containing the AP sites and stimulates cleavage of these AP sites at low magnesium concentrations.

KW - AP endonuclease 1

KW - apurinic/apyrimidinic site

KW - base excision repair

KW - Y-box-binding protein 1

UR - http://www.scopus.com/inward/record.url?scp=85038426679&partnerID=8YFLogxK

U2 - 10.1134/S0006297917120112

DO - 10.1134/S0006297917120112

M3 - Article

C2 - 29486702

AN - SCOPUS:85038426679

VL - 82

SP - 1521

EP - 1528

JO - Biochemistry (Moscow)

JF - Biochemistry (Moscow)

SN - 0006-2979

IS - 12

ER -

ID: 9443758