TY - JOUR

T1 - Xenobiotic-Metabolizing Enzymes in Trematodes

AU - Mordvinov, Viatcheslav

AU - Pakharukova, Maria

N1 - This research was funded by the Russian Science Foundation and Novosibirsk Oblast government [grant number 22-24-20010] to M.P.

PY - 2022/11/24

Y1 - 2022/11/24

N2 - Trematode infections occur worldwide causing considerable deterioration of human health and placing a substantial financial burden on the livestock industry. The hundreds of millions of people afflicted with trematode infections rely entirely on only two drugs (praziquantel and triclabendazole) for treatment. An understanding of anthelmintic biotransformation pathways in parasites should clarify factors that can modulate therapeutic potency of anthelmintics currently in use and may lead to the discovery of synergistic compounds for combination treatments. Despite the pronounced epidemiological significance of trematodes, there is still no adequate understanding of the functionality of their metabolic systems, including xenobiotic-metabolizing enzymes. The review is focused on the structure and functional significance of the xenobiotic-metabolizing system in trematodes. Knowledge in this field can solve practical problems related to the search for new targets for antiparasitic therapy based on a focused action on certain elements of the parasite's metabolic system. Knowledge of the functionality of this system is required to understand the adaptation of the biochemical processes of parasites residing in the host and mechanisms of drug resistance development, as well as to select a promising molecular target for the discovery and development of new anthelmintic drugs.

AB - Trematode infections occur worldwide causing considerable deterioration of human health and placing a substantial financial burden on the livestock industry. The hundreds of millions of people afflicted with trematode infections rely entirely on only two drugs (praziquantel and triclabendazole) for treatment. An understanding of anthelmintic biotransformation pathways in parasites should clarify factors that can modulate therapeutic potency of anthelmintics currently in use and may lead to the discovery of synergistic compounds for combination treatments. Despite the pronounced epidemiological significance of trematodes, there is still no adequate understanding of the functionality of their metabolic systems, including xenobiotic-metabolizing enzymes. The review is focused on the structure and functional significance of the xenobiotic-metabolizing system in trematodes. Knowledge in this field can solve practical problems related to the search for new targets for antiparasitic therapy based on a focused action on certain elements of the parasite's metabolic system. Knowledge of the functionality of this system is required to understand the adaptation of the biochemical processes of parasites residing in the host and mechanisms of drug resistance development, as well as to select a promising molecular target for the discovery and development of new anthelmintic drugs.

KW - ATP-binding cassette

KW - Trematoda

KW - anthelmintic

KW - cytochrome P450

KW - detoxification system

KW - glutathione S-transferase

KW - liver fluke

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85144675105&origin=inward&txGid=1bef32f73303d9358e959ce3406e58eb

UR - https://www.mendeley.com/catalogue/1523006e-a9ab-34ec-a53b-2c5c37afedea/

U2 - 10.3390/biomedicines10123039

DO - 10.3390/biomedicines10123039

M3 - Review article

C2 - 36551794

VL - 10

JO - Biomedicines

JF - Biomedicines

SN - 2227-9059

IS - 12

M1 - 3039

ER -