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Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models. / Kotova, Maria M; Galstyan, David S; Kolesnikova, Tatiana O et al.

In: Veterinary Sciences, Vol. 10, No. 2, 96, 29.01.2023.

Research output: Contribution to journal › Review article › peer-review

Harvard

Kotova, MM, Galstyan, DS, Kolesnikova, TO, de Abreu, MS, Amstislavskaya, TG, Strekalova, T, Petersen, EV, Yenkoyan, KB, Demin, KA & Kalueff, AV 2023, 'Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models', Veterinary Sciences, vol. 10, no. 2, 96. https://doi.org/10.3390/vetsci10020096

APA

Kotova, M. M., Galstyan, D. S., Kolesnikova, T. O., de Abreu, M. S., Amstislavskaya, T. G., Strekalova, T., Petersen, E. V., Yenkoyan, K. B., Demin, K. A., & Kalueff, A. V. (2023). Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models. Veterinary Sciences, 10(2), [96]. https://doi.org/10.3390/vetsci10020096

Vancouver

Kotova MM, Galstyan DS, Kolesnikova TO, de Abreu MS, Amstislavskaya TG, Strekalova T et al. Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models. Veterinary Sciences. 2023 Jan 29;10(2):96. doi: 10.3390/vetsci10020096

Author

Kotova, Maria M ; Galstyan, David S ; Kolesnikova, Tatiana O et al. / Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models. In: Veterinary Sciences. 2023 ; Vol. 10, No. 2.

BibTeX

@article{a9ba4d0551af421b846fc554cefd2faa,
title = "Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models",
abstract = "Antimicrobial drugs represent a diverse group of widely utilized antibiotic, antifungal, antiparasitic and antiviral agents. Their growing use and clinical importance necessitate our improved understanding of physiological effects of antimicrobial drugs, including their potential effects on the central nervous system (CNS), at molecular, cellular, and behavioral levels. In addition, antimicrobial drugs can alter the composition of gut microbiota, and hence affect the gut-microbiota-brain axis, further modulating brain and behavioral processes. Complementing rodent studies, the zebrafish (Danio rerio) emerges as a powerful model system for screening various antimicrobial drugs, including probing their putative CNS effects. Here, we critically discuss recent evidence on the effects of antimicrobial drugs on brain and behavior in zebrafish, and outline future related lines of research using this aquatic model organism.",
keywords = "antibiotic, antimicrobial drugs, behavior, brain, microbiota, zebrafish",
author = "Kotova, {Maria M} and Galstyan, {David S} and Kolesnikova, {Tatiana O} and {de Abreu}, {Murilo S} and Amstislavskaya, {Tamara G} and Tatyana Strekalova and Petersen, {Elena V} and Yenkoyan, {Konstantin B} and Demin, {Konstantin A} and Kalueff, {Allan V}",
note = "Funding: This work was supported by St. Petersburg State University (project ID 93020614). T.O.K. is supported by Sirius University of Science and Technology (project NRB-RND-2116). The funders had no role in the design, analyses, and interpretation of the submitted study, or decision to publish.",
year = "2023",
month = jan,
day = "29",
doi = "10.3390/vetsci10020096",
language = "English",
volume = "10",
journal = "Veterinary Sciences",
issn = "2306-7381",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "2",

}

RIS

TY - JOUR

T1 - Understanding CNS Effects of Antimicrobial Drugs Using Zebrafish Models

AU - Kotova, Maria M

AU - Galstyan, David S

AU - Kolesnikova, Tatiana O

AU - de Abreu, Murilo S

AU - Amstislavskaya, Tamara G

AU - Strekalova, Tatyana

AU - Petersen, Elena V

AU - Yenkoyan, Konstantin B

AU - Demin, Konstantin A

AU - Kalueff, Allan V

N1 - Funding: This work was supported by St. Petersburg State University (project ID 93020614). T.O.K. is supported by Sirius University of Science and Technology (project NRB-RND-2116). The funders had no role in the design, analyses, and interpretation of the submitted study, or decision to publish.

PY - 2023/1/29

Y1 - 2023/1/29

N2 - Antimicrobial drugs represent a diverse group of widely utilized antibiotic, antifungal, antiparasitic and antiviral agents. Their growing use and clinical importance necessitate our improved understanding of physiological effects of antimicrobial drugs, including their potential effects on the central nervous system (CNS), at molecular, cellular, and behavioral levels. In addition, antimicrobial drugs can alter the composition of gut microbiota, and hence affect the gut-microbiota-brain axis, further modulating brain and behavioral processes. Complementing rodent studies, the zebrafish (Danio rerio) emerges as a powerful model system for screening various antimicrobial drugs, including probing their putative CNS effects. Here, we critically discuss recent evidence on the effects of antimicrobial drugs on brain and behavior in zebrafish, and outline future related lines of research using this aquatic model organism.

AB - Antimicrobial drugs represent a diverse group of widely utilized antibiotic, antifungal, antiparasitic and antiviral agents. Their growing use and clinical importance necessitate our improved understanding of physiological effects of antimicrobial drugs, including their potential effects on the central nervous system (CNS), at molecular, cellular, and behavioral levels. In addition, antimicrobial drugs can alter the composition of gut microbiota, and hence affect the gut-microbiota-brain axis, further modulating brain and behavioral processes. Complementing rodent studies, the zebrafish (Danio rerio) emerges as a powerful model system for screening various antimicrobial drugs, including probing their putative CNS effects. Here, we critically discuss recent evidence on the effects of antimicrobial drugs on brain and behavior in zebrafish, and outline future related lines of research using this aquatic model organism.

KW - antibiotic

KW - antimicrobial drugs

KW - behavior

KW - brain

KW - microbiota

KW - zebrafish

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85149201751&origin=inward&txGid=c97f79ec72396f91934bc33a2aff848d

UR - https://www.mendeley.com/catalogue/285a3594-114c-3f8a-823a-c5d10d696685/

U2 - 10.3390/vetsci10020096

DO - 10.3390/vetsci10020096

M3 - Review article

C2 - 36851400

VL - 10

JO - Veterinary Sciences

JF - Veterinary Sciences

SN - 2306-7381

IS - 2

M1 - 96

ER -

ID: 44614570