Research output: Contribution to journal › Article › peer-review
Ultrasensitive detection of inhaled organic aerosol particles by accelerator mass spectrometry. / Parkhomchuk, E. V.; Gulevich, D. G.; Taratayko, A. I. et al.
In: Chemosphere, Vol. 159, 01.09.2016, p. 80-88.Research output: Contribution to journal › Article › peer-review
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TY - JOUR
T1 - Ultrasensitive detection of inhaled organic aerosol particles by accelerator mass spectrometry
AU - Parkhomchuk, E. V.
AU - Gulevich, D. G.
AU - Taratayko, A. I.
AU - Baklanov, A. M.
AU - Selivanova, A. V.
AU - Trubitsyna, T. A.
AU - Voronova, I. V.
AU - Kalinkin, P. N.
AU - Okunev, A. G.
AU - Rastigeev, S. A.
AU - Reznikov, V. A.
AU - Semeykina, V. S.
AU - Sashkina, K. A.
AU - Parkhomchuk, V. V.
PY - 2016/9/1
Y1 - 2016/9/1
N2 - Accelerator mass spectrometry (AMS) was shown to be applicable for studying the penetration of organic aerosols, inhaled by laboratory mice at ultra-low concentration ca. 103 cm-3. We synthesized polystyrene (PS) beads, composed of radiocarbon-labeled styrene, for testing them as model organic aerosols. As a source of radiocarbon we used methyl alcohol with radioactivity. Radiolabeled polystyrene beads were obtained by emulsifier-free emulsion polymerization of synthesized 14C-styrene initiated by K2S2O8 in aqueous media. Aerosol particles were produced by pneumatic spraying of diluted 14C-PS latex. Mice inhaled 14C-PS aerosol consisting of the mix of 103 225-nm particles per 1 cm3 and 5·103 25-nm particles per 1 cm3 for 30 min every day during five days. Several millions of 225-nm particles deposited in the lungs and slowly excreted from them during two weeks of postexposure. Penetration of particles matter was also observed for liver, kidneys and brain, but not for a heart.
AB - Accelerator mass spectrometry (AMS) was shown to be applicable for studying the penetration of organic aerosols, inhaled by laboratory mice at ultra-low concentration ca. 103 cm-3. We synthesized polystyrene (PS) beads, composed of radiocarbon-labeled styrene, for testing them as model organic aerosols. As a source of radiocarbon we used methyl alcohol with radioactivity. Radiolabeled polystyrene beads were obtained by emulsifier-free emulsion polymerization of synthesized 14C-styrene initiated by K2S2O8 in aqueous media. Aerosol particles were produced by pneumatic spraying of diluted 14C-PS latex. Mice inhaled 14C-PS aerosol consisting of the mix of 103 225-nm particles per 1 cm3 and 5·103 25-nm particles per 1 cm3 for 30 min every day during five days. Several millions of 225-nm particles deposited in the lungs and slowly excreted from them during two weeks of postexposure. Penetration of particles matter was also observed for liver, kidneys and brain, but not for a heart.
KW - Accelerator mass-spectrometry
KW - Low-dose inhalation
KW - Mice
KW - Organic aerosols
KW - Polystyrene beads
KW - Radiocarbon
UR - http://www.scopus.com/inward/record.url?scp=84973174909&partnerID=8YFLogxK
U2 - 10.1016/j.chemosphere.2016.05.078
DO - 10.1016/j.chemosphere.2016.05.078
M3 - Article
C2 - 27281540
AN - SCOPUS:84973174909
VL - 159
SP - 80
EP - 88
JO - Chemosphere
JF - Chemosphere
SN - 0045-6535
ER -
ID: 8716215