Ultrafine organic aerosol particles inhaled by mice at low doses remain in lungs more than half a year

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Ultrafine organic aerosol particles inhaled by mice at low doses remain in lungs more than half a year. / Parkhomchuk, Ekaterina V.; Prokopyeva, Elena A.; Gulevich, Dayana G. et al.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 62, No. 11, 01.09.2019, p. 785-793.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{14a29bc24d5746cdb09fe31b7b907b42,

title = "Ultrafine organic aerosol particles inhaled by mice at low doses remain in lungs more than half a year",

abstract = "Experimental results of the second series of experiments on the penetration of monodisperse polymeric particles, inhaled at low dose by mice, to different organs using direct way of particle registration, based on the ultra-sensitive accelerator mass spectrometer (AMS), are presented. Polystyrene (PS) beads, composed of radiocarbon-labeled styrene, were produced for testing them as model organic aerosols. Mice inhaled 14C-PS aerosol of 3·105 ultrafine particles per 1 cm3 for 30 minutes every day during 5 days. Long-term investigation showed that PS ultrafine particles have been effectively accumulated in lungs with the maximum content in the fifth day of postexposure, and have also appeared in liver on the fifth day of exposure and in the brain on the 30th day of experiments. No particles have been detected in kidneys, spleen, and excrements. Thirty-five millions of particles remained in the lungs after half a year of postexposure showing extremely slow removal of such particles from the organ.",

keywords = "accelerator mass spectrometry, low-dose inhalation, mice, organic aerosols, polystyrene beads, radiocarbon, PULMONARY, TRANSLOCATION, MASS-SPECTROMETER, CIRCULATION, OUTDOOR, SIZE, NANOPARTICLES, PARTICULATE AIR-POLLUTION, FINE PARTICLES, DAILY MORTALITY",

author = "Parkhomchuk, {Ekaterina V.} and Prokopyeva, {Elena A.} and Gulevich, {Dayana G.} and Taratayko, {Anrey I.} and Baklanov, {Anatoly M.} and Kalinkin, {Peter N.} and Rastigeev, {Sergey A.} and Kuleshov, {Dmitry V.} and Sashkina, {Kseniya A.} and Parkhomchuk, {Vasiliy V.}",

note = "{\textcopyright} 2019 John Wiley & Sons, Ltd.",

year = "2019",

month = sep,

day = "1",

doi = "10.1002/jlcr.3788",

language = "English",

volume = "62",

pages = "785--793",

journal = "Journal of Labelled Compounds and Radiopharmaceuticals",

issn = "0362-4803",

publisher = "Wiley-Blackwell",

number = "11",

}

RIS

TY - JOUR

T1 - Ultrafine organic aerosol particles inhaled by mice at low doses remain in lungs more than half a year

AU - Parkhomchuk, Ekaterina V.

AU - Prokopyeva, Elena A.

AU - Gulevich, Dayana G.

AU - Taratayko, Anrey I.

AU - Baklanov, Anatoly M.

AU - Kalinkin, Peter N.

AU - Rastigeev, Sergey A.

AU - Kuleshov, Dmitry V.

AU - Sashkina, Kseniya A.

AU - Parkhomchuk, Vasiliy V.

PY - 2019/9/1

Y1 - 2019/9/1

N2 - Experimental results of the second series of experiments on the penetration of monodisperse polymeric particles, inhaled at low dose by mice, to different organs using direct way of particle registration, based on the ultra-sensitive accelerator mass spectrometer (AMS), are presented. Polystyrene (PS) beads, composed of radiocarbon-labeled styrene, were produced for testing them as model organic aerosols. Mice inhaled 14C-PS aerosol of 3·105 ultrafine particles per 1 cm3 for 30 minutes every day during 5 days. Long-term investigation showed that PS ultrafine particles have been effectively accumulated in lungs with the maximum content in the fifth day of postexposure, and have also appeared in liver on the fifth day of exposure and in the brain on the 30th day of experiments. No particles have been detected in kidneys, spleen, and excrements. Thirty-five millions of particles remained in the lungs after half a year of postexposure showing extremely slow removal of such particles from the organ.

AB - Experimental results of the second series of experiments on the penetration of monodisperse polymeric particles, inhaled at low dose by mice, to different organs using direct way of particle registration, based on the ultra-sensitive accelerator mass spectrometer (AMS), are presented. Polystyrene (PS) beads, composed of radiocarbon-labeled styrene, were produced for testing them as model organic aerosols. Mice inhaled 14C-PS aerosol of 3·105 ultrafine particles per 1 cm3 for 30 minutes every day during 5 days. Long-term investigation showed that PS ultrafine particles have been effectively accumulated in lungs with the maximum content in the fifth day of postexposure, and have also appeared in liver on the fifth day of exposure and in the brain on the 30th day of experiments. No particles have been detected in kidneys, spleen, and excrements. Thirty-five millions of particles remained in the lungs after half a year of postexposure showing extremely slow removal of such particles from the organ.

KW - accelerator mass spectrometry

KW - low-dose inhalation

KW - mice

KW - organic aerosols

KW - polystyrene beads

KW - radiocarbon

KW - PULMONARY

KW - TRANSLOCATION

KW - MASS-SPECTROMETER

KW - CIRCULATION

KW - OUTDOOR

KW - SIZE

KW - NANOPARTICLES

KW - PARTICULATE AIR-POLLUTION

KW - FINE PARTICLES

KW - DAILY MORTALITY

UR - http://www.scopus.com/inward/record.url?scp=85071370547&partnerID=8YFLogxK

U2 - 10.1002/jlcr.3788

DO - 10.1002/jlcr.3788

M3 - Article

C2 - 31325367

AN - SCOPUS:85071370547

VL - 62

SP - 785

EP - 793

JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

IS - 11

ER -

ID: 21344313