Translocation of Oligonucleotide–Oligosaccharide Complexes into Cells of the Brain

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Translocation of Oligonucleotide–Oligosaccharide Complexes into Cells of the Brain. / Dygalo, N. N.; Kalinina, T. S.; Lanshakov, D. A.

In: Doklady Biochemistry and Biophysics, Vol. 479, No. 1, 15, 01.03.2018, p. 108-110.

Research output: Contribution to journal › Article › peer-review

BibTeX

@article{36b297de4f404affbea52eb90895dc14,

title = "Translocation of Oligonucleotide–Oligosaccharide Complexes into Cells of the Brain",

abstract = "Irradiation of a mixture of oligonucleotides with dextran resulted in the formation of a complex that is detected by a decelerated migration of an irradiated sample in electrophoretic gel compared to a non-irradiated one. When injected into the brain of neonatal rats, the formed complex penetrated into the cells 3 times easier compared to the original oligonucleotide, thus indicating that the use of radiation crosslinking of oligonucleotides with oligosaccharides is promising to enhance the efficiency of delivery of gene-targeted oligonucleotide drugs into cells.",

keywords = "Animals, Biological Transport, Brain/metabolism, Oligonucleotides/metabolism, Oligosaccharides/metabolism, Rats",

author = "Dygalo, {N. N.} and Kalinina, {T. S.} and Lanshakov, {D. A.}",

note = "Funding Information: We are grateful to M.V. Korobeinikov for irradiation of samples in the accelerator. This study was supported by a program of the Russian Academy of Sciences (project no. 0324-2016-0011). Publisher Copyright: {\textcopyright} 2018, Pleiades Publishing, Ltd.",

year = "2018",

month = mar,

day = "1",

doi = "10.1134/S160767291802014X",

language = "English",

volume = "479",

pages = "108--110",

journal = "Doklady Biochemistry and Biophysics",

issn = "1607-6729",

publisher = "Maik Nauka-Interperiodica Publishing",

number = "1",

}

RIS

TY - JOUR

T1 - Translocation of Oligonucleotide–Oligosaccharide Complexes into Cells of the Brain

AU - Dygalo, N. N.

AU - Kalinina, T. S.

AU - Lanshakov, D. A.

N1 - Funding Information: We are grateful to M.V. Korobeinikov for irradiation of samples in the accelerator. This study was supported by a program of the Russian Academy of Sciences (project no. 0324-2016-0011). Publisher Copyright: © 2018, Pleiades Publishing, Ltd.

PY - 2018/3/1

Y1 - 2018/3/1

N2 - Irradiation of a mixture of oligonucleotides with dextran resulted in the formation of a complex that is detected by a decelerated migration of an irradiated sample in electrophoretic gel compared to a non-irradiated one. When injected into the brain of neonatal rats, the formed complex penetrated into the cells 3 times easier compared to the original oligonucleotide, thus indicating that the use of radiation crosslinking of oligonucleotides with oligosaccharides is promising to enhance the efficiency of delivery of gene-targeted oligonucleotide drugs into cells.

AB - Irradiation of a mixture of oligonucleotides with dextran resulted in the formation of a complex that is detected by a decelerated migration of an irradiated sample in electrophoretic gel compared to a non-irradiated one. When injected into the brain of neonatal rats, the formed complex penetrated into the cells 3 times easier compared to the original oligonucleotide, thus indicating that the use of radiation crosslinking of oligonucleotides with oligosaccharides is promising to enhance the efficiency of delivery of gene-targeted oligonucleotide drugs into cells.

KW - Animals

KW - Biological Transport

KW - Brain/metabolism

KW - Oligonucleotides/metabolism

KW - Oligosaccharides/metabolism

KW - Rats

UR - http://www.scopus.com/inward/record.url?scp=85047212335&partnerID=8YFLogxK

UR - https://www.elibrary.ru/item.asp?id=35494602

U2 - 10.1134/S160767291802014X

DO - 10.1134/S160767291802014X

M3 - Article

C2 - 29779110

AN - SCOPUS:85047212335

VL - 479

SP - 108

EP - 110

JO - Doklady Biochemistry and Biophysics

JF - Doklady Biochemistry and Biophysics

SN - 1607-6729

IS - 1

M1 - 15

ER -

ID: 13487369