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Transient protein–protein complexes in base excision repair. / Endutkin, Anton V.; Yudkina, Anna V.; Sidorenko, Viktoriya S. et al.

In: Journal of Biomolecular Structure and Dynamics, Vol. 37, No. 17, 22.11.2019, p. 4407-4418.

Research output: Contribution to journal › Review article › peer-review

Harvard

Endutkin, AV, Yudkina, AV, Sidorenko, VS & Zharkov, DO 2019, 'Transient protein–protein complexes in base excision repair', Journal of Biomolecular Structure and Dynamics, vol. 37, no. 17, pp. 4407-4418. https://doi.org/10.1080/07391102.2018.1553741

APA

Endutkin, A. V., Yudkina, A. V., Sidorenko, V. S., & Zharkov, D. O. (2019). Transient protein–protein complexes in base excision repair. Journal of Biomolecular Structure and Dynamics, 37(17), 4407-4418. https://doi.org/10.1080/07391102.2018.1553741

Vancouver

Endutkin AV, Yudkina AV, Sidorenko VS, Zharkov DO. Transient protein–protein complexes in base excision repair. Journal of Biomolecular Structure and Dynamics. 2019 Nov 22;37(17):4407-4418. doi: 10.1080/07391102.2018.1553741

Author

Endutkin, Anton V. ; Yudkina, Anna V. ; Sidorenko, Viktoriya S. et al. / Transient protein–protein complexes in base excision repair. In: Journal of Biomolecular Structure and Dynamics. 2019 ; Vol. 37, No. 17. pp. 4407-4418.

BibTeX

@article{98a7980ab1d34f1fbdea1b5ad9f28b85,
title = "Transient protein–protein complexes in base excision repair",
abstract = "Transient protein–protein complexes are of great importance for organizing multiple enzymatic reactions into productive reaction pathways. Base excision repair (BER), a process of critical importance for maintaining genome stability against a plethora of DNA-damaging factors, involves several enzymes, including DNA glycosylases, AP endonucleases, DNA polymerases, DNA ligases and accessory proteins acting sequentially on the same damaged site in DNA. Rather than being assembled into one stable multisubunit complex, these enzymes pass the repair intermediates between them in a highly coordinated manner. In this review, we discuss the nature and the role of transient complexes arising during BER as deduced from structural and kinetic data. Almost all of the transient complexes are DNA-mediated, although some may also exist in solution and strengthen under specific conditions. The best-studied example, the interactions between DNA glycosylases and AP endonucleases, is discussed in more detail to provide a framework for distinguishing between stable and transient complexes based on the kinetic data.",
keywords = "AP endonucleases, Base excision repair, DNA glycosylases, transient protein–protein complexes",
author = "Endutkin, {Anton V.} and Yudkina, {Anna V.} and Sidorenko, {Viktoriya S.} and Zharkov, {Dmitry O.}",
year = "2019",
month = nov,
day = "22",
doi = "10.1080/07391102.2018.1553741",
language = "English",
volume = "37",
pages = "4407--4418",
journal = "Journal of Biomolecular Structure and Dynamics",
issn = "0739-1102",
publisher = "Taylor and Francis Ltd.",
number = "17",

}

RIS

TY - JOUR

T1 - Transient protein–protein complexes in base excision repair

AU - Endutkin, Anton V.

AU - Yudkina, Anna V.

AU - Sidorenko, Viktoriya S.

AU - Zharkov, Dmitry O.

PY - 2019/11/22

Y1 - 2019/11/22

N2 - Transient protein–protein complexes are of great importance for organizing multiple enzymatic reactions into productive reaction pathways. Base excision repair (BER), a process of critical importance for maintaining genome stability against a plethora of DNA-damaging factors, involves several enzymes, including DNA glycosylases, AP endonucleases, DNA polymerases, DNA ligases and accessory proteins acting sequentially on the same damaged site in DNA. Rather than being assembled into one stable multisubunit complex, these enzymes pass the repair intermediates between them in a highly coordinated manner. In this review, we discuss the nature and the role of transient complexes arising during BER as deduced from structural and kinetic data. Almost all of the transient complexes are DNA-mediated, although some may also exist in solution and strengthen under specific conditions. The best-studied example, the interactions between DNA glycosylases and AP endonucleases, is discussed in more detail to provide a framework for distinguishing between stable and transient complexes based on the kinetic data.

AB - Transient protein–protein complexes are of great importance for organizing multiple enzymatic reactions into productive reaction pathways. Base excision repair (BER), a process of critical importance for maintaining genome stability against a plethora of DNA-damaging factors, involves several enzymes, including DNA glycosylases, AP endonucleases, DNA polymerases, DNA ligases and accessory proteins acting sequentially on the same damaged site in DNA. Rather than being assembled into one stable multisubunit complex, these enzymes pass the repair intermediates between them in a highly coordinated manner. In this review, we discuss the nature and the role of transient complexes arising during BER as deduced from structural and kinetic data. Almost all of the transient complexes are DNA-mediated, although some may also exist in solution and strengthen under specific conditions. The best-studied example, the interactions between DNA glycosylases and AP endonucleases, is discussed in more detail to provide a framework for distinguishing between stable and transient complexes based on the kinetic data.

KW - AP endonucleases

KW - Base excision repair

KW - DNA glycosylases

KW - transient protein–protein complexes

UR - http://www.scopus.com/inward/record.url?scp=85059349538&partnerID=8YFLogxK

U2 - 10.1080/07391102.2018.1553741

DO - 10.1080/07391102.2018.1553741

M3 - Review article

C2 - 30488779

AN - SCOPUS:85059349538

VL - 37

SP - 4407

EP - 4418

JO - Journal of Biomolecular Structure and Dynamics

JF - Journal of Biomolecular Structure and Dynamics

SN - 0739-1102

IS - 17

ER -

ID: 18066182