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Towards reliable diagnostics of prostate cancer via breath. / Maiti, K. S.; Fill, E.; Strittmatter, F. et al.

In: Scientific Reports, Vol. 11, No. 1, 18381, 12.2021.

Research output: Contribution to journalArticlepeer-review

Harvard

Maiti, KS, Fill, E, Strittmatter, F, Volz, Y, Sroka, R & Apolonski, A 2021, 'Towards reliable diagnostics of prostate cancer via breath', Scientific Reports, vol. 11, no. 1, 18381. https://doi.org/10.1038/s41598-021-96845-z

APA

Maiti, K. S., Fill, E., Strittmatter, F., Volz, Y., Sroka, R., & Apolonski, A. (2021). Towards reliable diagnostics of prostate cancer via breath. Scientific Reports, 11(1), [18381]. https://doi.org/10.1038/s41598-021-96845-z

Vancouver

Maiti KS, Fill E, Strittmatter F, Volz Y, Sroka R, Apolonski A. Towards reliable diagnostics of prostate cancer via breath. Scientific Reports. 2021 Dec;11(1):18381. doi: 10.1038/s41598-021-96845-z

Author

Maiti, K. S. ; Fill, E. ; Strittmatter, F. et al. / Towards reliable diagnostics of prostate cancer via breath. In: Scientific Reports. 2021 ; Vol. 11, No. 1.

BibTeX

@article{4eb307a6612546e2adc296bcab50ea3e,
title = "Towards reliable diagnostics of prostate cancer via breath",
abstract = "Early detection of cancer is a key ingredient for saving many lives. Unfortunately, cancers of the urogenital system are difficult to detect at early stage. The existing noninvasive diagnostics of prostate cancer (PCa) suffer from low accuracy (< 70%) even at advanced stages. In an attempt to improve the accuracy, a small breath study of 63 volunteers representing three groups: (1) of 19 healthy, (2) 28 with PCa, (3) with 8 kidney cancer (KC) and 8 bladder cancer (BC) was performed. Ultrabroadband mid-infrared Fourier absorption spectroscopy revealed eight spectral ranges (SRs) that differentiate the groups. The resulting accuracies of supervised analyses exceeded 95% for four SRs in distinguishing (1) vs (2), three for (1) vs (3) and four SRs for (1) vs (2) + (3). The SRs were then attributed to volatile metabolites. Their origin and involvement in urogenital carcinogenesis are discussed.",
author = "Maiti, {K. S.} and E. Fill and F. Strittmatter and Y. Volz and R. Sroka and A. Apolonski",
note = "Publisher Copyright: {\textcopyright} 2021, The Author(s).",
year = "2021",
month = dec,
doi = "10.1038/s41598-021-96845-z",
language = "English",
volume = "11",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Towards reliable diagnostics of prostate cancer via breath

AU - Maiti, K. S.

AU - Fill, E.

AU - Strittmatter, F.

AU - Volz, Y.

AU - Sroka, R.

AU - Apolonski, A.

N1 - Publisher Copyright: © 2021, The Author(s).

PY - 2021/12

Y1 - 2021/12

N2 - Early detection of cancer is a key ingredient for saving many lives. Unfortunately, cancers of the urogenital system are difficult to detect at early stage. The existing noninvasive diagnostics of prostate cancer (PCa) suffer from low accuracy (< 70%) even at advanced stages. In an attempt to improve the accuracy, a small breath study of 63 volunteers representing three groups: (1) of 19 healthy, (2) 28 with PCa, (3) with 8 kidney cancer (KC) and 8 bladder cancer (BC) was performed. Ultrabroadband mid-infrared Fourier absorption spectroscopy revealed eight spectral ranges (SRs) that differentiate the groups. The resulting accuracies of supervised analyses exceeded 95% for four SRs in distinguishing (1) vs (2), three for (1) vs (3) and four SRs for (1) vs (2) + (3). The SRs were then attributed to volatile metabolites. Their origin and involvement in urogenital carcinogenesis are discussed.

AB - Early detection of cancer is a key ingredient for saving many lives. Unfortunately, cancers of the urogenital system are difficult to detect at early stage. The existing noninvasive diagnostics of prostate cancer (PCa) suffer from low accuracy (< 70%) even at advanced stages. In an attempt to improve the accuracy, a small breath study of 63 volunteers representing three groups: (1) of 19 healthy, (2) 28 with PCa, (3) with 8 kidney cancer (KC) and 8 bladder cancer (BC) was performed. Ultrabroadband mid-infrared Fourier absorption spectroscopy revealed eight spectral ranges (SRs) that differentiate the groups. The resulting accuracies of supervised analyses exceeded 95% for four SRs in distinguishing (1) vs (2), three for (1) vs (3) and four SRs for (1) vs (2) + (3). The SRs were then attributed to volatile metabolites. Their origin and involvement in urogenital carcinogenesis are discussed.

UR - http://www.scopus.com/inward/record.url?scp=85115203276&partnerID=8YFLogxK

U2 - 10.1038/s41598-021-96845-z

DO - 10.1038/s41598-021-96845-z

M3 - Article

C2 - 34526529

AN - SCOPUS:85115203276

VL - 11

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 18381

ER -

ID: 34242065