Research output: Contribution to journal › Article › peer-review
Towards reliable diagnostics of prostate cancer via breath. / Maiti, K. S.; Fill, E.; Strittmatter, F. et al.
In: Scientific Reports, Vol. 11, No. 1, 18381, 12.2021.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Towards reliable diagnostics of prostate cancer via breath
AU - Maiti, K. S.
AU - Fill, E.
AU - Strittmatter, F.
AU - Volz, Y.
AU - Sroka, R.
AU - Apolonski, A.
N1 - Publisher Copyright: © 2021, The Author(s).
PY - 2021/12
Y1 - 2021/12
N2 - Early detection of cancer is a key ingredient for saving many lives. Unfortunately, cancers of the urogenital system are difficult to detect at early stage. The existing noninvasive diagnostics of prostate cancer (PCa) suffer from low accuracy (< 70%) even at advanced stages. In an attempt to improve the accuracy, a small breath study of 63 volunteers representing three groups: (1) of 19 healthy, (2) 28 with PCa, (3) with 8 kidney cancer (KC) and 8 bladder cancer (BC) was performed. Ultrabroadband mid-infrared Fourier absorption spectroscopy revealed eight spectral ranges (SRs) that differentiate the groups. The resulting accuracies of supervised analyses exceeded 95% for four SRs in distinguishing (1) vs (2), three for (1) vs (3) and four SRs for (1) vs (2) + (3). The SRs were then attributed to volatile metabolites. Their origin and involvement in urogenital carcinogenesis are discussed.
AB - Early detection of cancer is a key ingredient for saving many lives. Unfortunately, cancers of the urogenital system are difficult to detect at early stage. The existing noninvasive diagnostics of prostate cancer (PCa) suffer from low accuracy (< 70%) even at advanced stages. In an attempt to improve the accuracy, a small breath study of 63 volunteers representing three groups: (1) of 19 healthy, (2) 28 with PCa, (3) with 8 kidney cancer (KC) and 8 bladder cancer (BC) was performed. Ultrabroadband mid-infrared Fourier absorption spectroscopy revealed eight spectral ranges (SRs) that differentiate the groups. The resulting accuracies of supervised analyses exceeded 95% for four SRs in distinguishing (1) vs (2), three for (1) vs (3) and four SRs for (1) vs (2) + (3). The SRs were then attributed to volatile metabolites. Their origin and involvement in urogenital carcinogenesis are discussed.
UR - http://www.scopus.com/inward/record.url?scp=85115203276&partnerID=8YFLogxK
U2 - 10.1038/s41598-021-96845-z
DO - 10.1038/s41598-021-96845-z
M3 - Article
C2 - 34526529
AN - SCOPUS:85115203276
VL - 11
JO - Scientific Reports
JF - Scientific Reports
SN - 2045-2322
IS - 1
M1 - 18381
ER -
ID: 34242065