Towards Modeling Anhedonia and Its Treatment in Zebrafish. / de Abreu, Murilo S.; Costa, Fabiano; Giacomini, Ana C. V. V. et al.
In: International journal of neuropsychopharmacology, Vol. 25, No. 4, 01.04.2022, p. 293-306.Research output: Contribution to journal › Review article › peer-review
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TY - JOUR
T1 - Towards Modeling Anhedonia and Its Treatment in Zebrafish
AU - de Abreu, Murilo S.
AU - Costa, Fabiano
AU - Giacomini, Ana C. V. V.
AU - Demin, Konstantin A.
AU - Zabegalov, Konstantin N.
AU - Maslov, Gleb O.
AU - Kositsyn, Yuriy M.
AU - Petersen, Elena
AU - Strekalova, Tatiana
AU - Rosemberg, Denis B.
AU - Kalueff, Allan
N1 - The study is supported by the Southwest University Zebrafish Platform Construction Funds (Chongqing, China). A.V.K. is the Chair of the International Zebrafish Neuroscience Research Consortium (ZNRC) that coordinated this collaborative project. D.B.R.'s research is also supported by Programa de Excelencia Academica (PROEX)/Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) (process no. 23038.005450/2020-19) and Program PQ-"Gaucho" Fundacao de Amparo a Pesquisa do Rio Grande do Sul (FAPERGS) (process no. 19/2551-0001764-2) fellowship grants. A.C.V.V.G. is supported by the FAPERGS research fellowships 19/2551-0001-669-7. A.V.K. is supported by the Zebrafish Platform Construction Fund from the Southwest University (Chongqing, China). K.A.D. is supported by the Special Rector's Fellowship for SPSU students, and state budgetary funds to Granov Russian Scientific Research Center of Radiology and Surgical Technologies (project 121040200141-4). The collaboration was supported by the Russian Science Foundation grant 20-65-46006. The work used the equipment of the Resource Fund of Applied Genetics MIPT (support grant 075-15-2021-684). K.N.Z., F.C. and G.O.M. are supported by Sirius University of Science and Technology. The funders had no role in the design, analyses and interpretation of the submitted study, or decision to publish.
PY - 2022/4/1
Y1 - 2022/4/1
N2 - Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and extensively validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders, including depression. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications.
AB - Mood disorders, especially depression, are a major cause of human disability. The loss of pleasure (anhedonia) is a common, severely debilitating symptom of clinical depression. Experimental animal models are widely used to better understand depression pathogenesis and to develop novel antidepressant therapies. In rodents, various experimental models of anhedonia have already been developed and extensively validated. Complementing rodent studies, the zebrafish (Danio rerio) is emerging as a powerful model organism to assess pathobiological mechanisms of affective disorders, including depression. Here, we critically discuss the potential of zebrafish for modeling anhedonia and studying its molecular mechanisms and translational implications.
KW - Anhedonia
KW - animal models
KW - antidepressant
KW - behavior
KW - zebrafish
KW - CONDITIONED PLACE PREFERENCE
KW - STRESS-INDUCED ANHEDONIA
KW - MAJOR DEPRESSIVE DISORDER
KW - NUCLEUS-ACCUMBENS DOPAMINE
KW - ANIMAL-MODEL
KW - SOCIAL-INTERACTION
KW - ADULT ZEBRAFISH
KW - DANIO-RERIO
KW - BIOLOGICAL MECHANISMS
KW - RECOGNITION MEMORY
KW - Antidepressive Agents/pharmacology
KW - Zebrafish
KW - Behavior, Animal
KW - Animals
KW - Disease Models, Animal
UR - http://www.scopus.com/inward/record.url?scp=85128800030&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/965f5d78-c50e-3776-a801-21800758f63f/
U2 - 10.1093/ijnp/pyab092
DO - 10.1093/ijnp/pyab092
M3 - Review article
C2 - 34918075
VL - 25
SP - 293
EP - 306
JO - International journal of neuropsychopharmacology
JF - International journal of neuropsychopharmacology
SN - 1461-1457
IS - 4
ER -
ID: 35969251