TY - JOUR

T1 - Towards experimental models of delirium utilizing zebrafish

AU - Maslov, Gleb O

AU - Zabegalov, Konstantin N

AU - Demin, Konstantin A

AU - Kolesnikova, Tatiana O

AU - Kositsyn, Yuriy M

AU - de Abreu, Murilo S

AU - Petersen, Elena V

AU - Kalueff, Allan V

N1 - Acknowledgement: This study is supported by Sirius University of Science and Technology (Sochi, Russia). A.V.K. is supported by St. Petersburg State University. The study utilized the facilities and equipment of the Resource Fund of Applied Genetics MIPT (support grant 075-15-2021-684). Copyright © 2023 Elsevier B.V. All rights reserved.

PY - 2023/9/13

Y1 - 2023/9/13

N2 - Delirium is an acute neuropsychiatric syndrome characterized by impaired behavior and cognition. Although the syndrome has been known for millennia, its CNS mechanisms and risk factors remain poorly understood. Experimental animal models, especially rodent-based, are commonly used to probe various pathogenetic aspects of delirium. Complementing rodents, the zebrafish (Danio rerio) emerges as a promising novel model organism to study delirium. Zebrafish demonstrate high genetic and physiological homology to mammals, easy maintenance, robust behaviors in various sensitive behavioral tests, and the potential to screen for pharmacological agents relevant to delirium. Here, we critically discuss recent developments in the field, and emphasize the developing utility of zebrafish models for translational studies of delirium and deliriant drugs. Overall, the zebrafish represents a valuable and promising aquatic model species whose use may help understand delirium etiology, as well as develop novel therapies for this severely debilitating disorder.

AB - Delirium is an acute neuropsychiatric syndrome characterized by impaired behavior and cognition. Although the syndrome has been known for millennia, its CNS mechanisms and risk factors remain poorly understood. Experimental animal models, especially rodent-based, are commonly used to probe various pathogenetic aspects of delirium. Complementing rodents, the zebrafish (Danio rerio) emerges as a promising novel model organism to study delirium. Zebrafish demonstrate high genetic and physiological homology to mammals, easy maintenance, robust behaviors in various sensitive behavioral tests, and the potential to screen for pharmacological agents relevant to delirium. Here, we critically discuss recent developments in the field, and emphasize the developing utility of zebrafish models for translational studies of delirium and deliriant drugs. Overall, the zebrafish represents a valuable and promising aquatic model species whose use may help understand delirium etiology, as well as develop novel therapies for this severely debilitating disorder.

KW - Delirium

KW - Drug screening

KW - Experimental models

KW - Zebrafish

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85166939869&origin=inward&txGid=1d76fb3d75b71f8451dfd940b0d44255

UR - https://www.mendeley.com/catalogue/e8bd2ce5-5051-3d02-abfd-2e98424a49df/

U2 - 10.1016/j.bbr.2023.114607

DO - 10.1016/j.bbr.2023.114607

M3 - Review article

C2 - 37524203

VL - 453

JO - Behavioural Brain Research

JF - Behavioural Brain Research

SN - 0166-4328

M1 - 114607

ER -