TY - JOUR

T1 - Time-dependent renal pathologies associated with the liver fluke infection, opisthorchiasis felinea

AU - Kapushchak, Yaroslav K.

AU - Zaparina, Oxana G.

AU - Mordvinov, Viatcheslav A.

AU - Pakharukova, Maria Y.

N1 - Funding Information: The research was funded by the Russian Foundation for Basic Research and Novosibirsk region , project number 20–415–543016_r_mol_a_Novosibirsk (for OGZ ) and a state project for the ICG SB RAS [ project No. 0259–2021–0014 (for MYP), , No.0259–2019–0003 (for YKK)]. Publisher Copyright: © 2021 Elsevier B.V.

PY - 2022/4

Y1 - 2022/4

N2 - Fish-borne trematode infections affect the health of more than 18 million people in Russia and Asian countries. Infection of humans and other mammals with the liver fluke Opisthorchis felineus (Rivolta, 1884) is accompanied by gradual development of liver disorders. Although there is indirect evidence that opisthorchiasis may be associated with damage to other organs, direct evidence of the connection between opisthorchiasis felinea and a kidney pathology has not yet been reported. To gain first insights into the possible relation, we investigated time course profiles of blood markers of renal failure as well as renal histological changes during opisthorchiasis from 1 month to 1.5 years postinfection in golden hamsters Mesocricetus auratus. For the first time, we showed that opisthorchiasis felinea leads to the development of glomerulopathy. In particular, O. felineus infection provoked gradual increases in serum creatinine, serum glucose, and urine protein concentrations. Moreover, there was gradual accumulation of renal tubular casts and of the mesangial matrix. Although the mechanisms underlying these renal pathologies remain unclear and require further research, we can conclude that O. felineus infection causes gradual progression of glomerulopathy accompanied by tubulopathy. Thus, overall, these aberrations correlate with the time course of hepatic pathological changes in opisthorchiasis felinea.

AB - Fish-borne trematode infections affect the health of more than 18 million people in Russia and Asian countries. Infection of humans and other mammals with the liver fluke Opisthorchis felineus (Rivolta, 1884) is accompanied by gradual development of liver disorders. Although there is indirect evidence that opisthorchiasis may be associated with damage to other organs, direct evidence of the connection between opisthorchiasis felinea and a kidney pathology has not yet been reported. To gain first insights into the possible relation, we investigated time course profiles of blood markers of renal failure as well as renal histological changes during opisthorchiasis from 1 month to 1.5 years postinfection in golden hamsters Mesocricetus auratus. For the first time, we showed that opisthorchiasis felinea leads to the development of glomerulopathy. In particular, O. felineus infection provoked gradual increases in serum creatinine, serum glucose, and urine protein concentrations. Moreover, there was gradual accumulation of renal tubular casts and of the mesangial matrix. Although the mechanisms underlying these renal pathologies remain unclear and require further research, we can conclude that O. felineus infection causes gradual progression of glomerulopathy accompanied by tubulopathy. Thus, overall, these aberrations correlate with the time course of hepatic pathological changes in opisthorchiasis felinea.

KW - Kidney abnormality

KW - Kidney failure

KW - Opisthorchiasis

KW - Opisthorchis felineus

KW - Systemic disease

UR - http://www.scopus.com/inward/record.url?scp=85122531825&partnerID=8YFLogxK

U2 - 10.1016/j.actatropica.2021.106282

DO - 10.1016/j.actatropica.2021.106282

M3 - Article

C2 - 34954256

AN - SCOPUS:85122531825

VL - 228

JO - Acta Tropica

JF - Acta Tropica

SN - 0001-706X

M1 - 106282

ER -